A5088837397- Immunotherapy and Immune Responses
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Mesoporous Materials and Catalysis
- Advancements in Battery Materials
- Hydrogels: synthesis, properties, applications
- Supercapacitor Materials and Fabrication
- Conducting polymers and applications
- Advanced Nanomaterials in Catalysis
- RNA Interference and Gene Delivery
- Graphene and Nanomaterials Applications
- Advanced Materials and Mechanics
- 3D Printing in Biomedical Research
- Advanced Sensor and Energy Harvesting Materials
- Quantum Dots Synthesis And Properties
- Gold and Silver Nanoparticles Synthesis and Applications
- Advanced biosensing and bioanalysis techniques
- Nanocluster Synthesis and Applications
- Engineering Applied Research
- Electrospun Nanofibers in Biomedical Applications
- Advanced Battery Materials and Technologies
- Electrochemical sensors and biosensors
- Polymer Surface Interaction Studies
- Catalytic Processes in Materials Science
- Cancer Immunotherapy and Biomarkers
Sungkyunkwan University
2016-2025
Samsung (South Korea)
2005-2025
Seoul National University
2003-2025
Impact
2025
Samsung (United Kingdom)
2025
Department of Medical Sciences
2025
Gumi Electronics & Information Technology Research Institute (South Korea)
2025
Korea Advanced Institute of Science and Technology
1998-2024
Jeonbuk National University
2016-2024
Gyeongsang National University
2024
Abstract In this review, the progress made in last ten years concerning synthesis of porous carbon materials is summarized. Porous with various pore sizes and structures have been synthesized using several different routes. Microporous activated carbons through activation process. Ordered microporous zeolites as templates. Mesoporous a disordered structure methods, including catalytic metal species, carbonization polymer/polymer blends, organic aerogels, template silica nanoparticles....
Magnetic, fluorescent core–shell nanoparticles consist of a single Fe3O4 nanocrystal core and dye-doped mesoporous silica shell with poly(ethylene glycol) coating (see picture TEM images schematic depictions). These can be used as magnetic resonance fluorescence imaging agents, drug delivery vehicles, thus making them novel candidates for simultaneous cancer diagnosis therapy. Detailed facts importance to specialist readers are published "Supporting Information". Such documents...
We synthesized uniform pore-sized mesoporous silica spheres embedded with magnetite nanocrystal and quantum dots. The magnetic separation, luminescent detection, controlled release of drugs were demonstrated using the monodisperse nanocrystals.
Highly versatile nanocomposite nanoparticles were synthesized by decorating the surface of mesoporous dye-doped silica with multiple magnetite nanocrystals. The superparamagnetic property nanocrystals enabled to be used as a contrast agent in magnetic resonance (MR) imaging, and dye molecule framework imparted optical imaging modality. Integrating multitude on resulted remarkable enhancement MR signal due synergistic magnetism. An anticancer drug, doxorubicin (DOX), could loaded pores...
Porous biomaterials have been widely used as scaffolds in tissue engineering and cell-based therapies. The release of biological agents from conventional porous is typically governed by molecular diffusion, material degradation, cell migration, which do not allow for dynamic external regulation. We present a new active scaffold that can be remotely controlled magnetic field to deliver various on demand. scaffold, the form macroporous ferrogel, gives large deformation volume change over 70%...
Nonnegative matrix factorization (NMF) determines a lower rank approximation of $A \in \mathbb{R}^{m \times n} \approx WH$ where an integer $k \ll \min(m,n)$ is given and nonnegativity imposed on all components the factors $W k}$ $H \mathbb{R}^{k n}$. NMF has attracted much attention for over decade been successfully applied to numerous data analysis problems. In applications are necessarily nonnegative, such as chemical concentrations in experimental results or pixels digital images,...
Targeting cancer: Multifunctional magnetic gold nanoshells (Mag-GNS) are prepared by coating silica spheres with embedded Fe3O4 nanoparticles. The nanoparticles allow resonance imaging (MRI) for diagnosis, and the enable photothermal therapy. By attaching an antibody to Mag-GNS a poly(ethylene glycol) (PEG) linker, cancer cells can be targeted. Supporting information this article is available on WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z602471_s.pdf or from author. Please...
Mesoporous silica-coated hollow manganese oxide (HMnO@mSiO(2)) nanoparticles were developed as a novel T(1) magnetic resonance imaging (MRI) contrast agent. We hypothesized that the mesoporous structure of nanoparticle shell enables optimal access water molecules to core, and consequently, an effective longitudinal (R(1)) relaxation enhancement protons, which value was measured be 0.99 (mM(-1)s(-1)) at 11.7 T. Adipose-derived mesenchymal stem cells (MSCs) efficiently labeled using...
Multifunctional polymer nanomedical platforms make simultaneous cancer-targeted MRI or optical imaging together with efficient drug delivery in vitro possible. In addition, clusters of Fe3O4 nanoparticles loaded the endow magnetic guiding particles, providing synergetic targeting efficiency. Supporting information for this article is available on WWW under http://www.wiley-vch.de/contents/jc_2089/2008/c1726_s.pdf from author. Please note: The publisher not responsible content functionality...
Biological systems are exquisitely sensitive to the location and timing of physiologic cues drugs. This spatiotemporal sensitivity presents opportunities for developing new therapeutic approaches. Polymer-based delivery used extensively attaining localized, sustained release bioactive molecules. However, these devices typically designed achieve a constant rate release. We hypothesized that it would be possible create digital drug release, which could accelerated then switched back off, on...
Suitably integrating multiple nanomaterials into nanostructured particle systems with specific combinations of properties has recently attracted significant attention in the research community. In particular, numerous have been designed and fabricated by diverse materials monodispersed silica nanoparticles. One or more distinct can be assembled on, encapsulated within, integrated both inside on surface nanoparticles using different chemistries techniques to create multifunctional...
"Attractive" catalyst: Molybdenum oxide nanoparticles have been incorporated into a mesoporous silica shell and coated on silica-coated magnetite for use as magnetically separable heterogeneous epoxidation catalyst. This catalyst, which has low Mo loading of 1 mol %, can be recycled reused six times in the cis-cyclooctene with no major loss activity (see picture). Supporting information this article is available WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z702386_s.pdf or from...
Abstract For the practical use of synthetic hydrogels as artificial biological tissues, flexible electronics, and conductive membranes, achieving requirements for specific mechanical properties is one most prominent issues. Here, we demonstrate superstrong, superstiff, alginate with densely interconnecting networks implemented via simple reconstructing processes, consisting anisotropic densification pre-gel a subsequent ionic crosslinking rehydration. The reconstructed hydrogel exhibits...
Abstract Transdermal drug delivery patches based on hydrogels are widely used for the transdermal of diverse drugs. However, most do not exhibit adequate adhesiveness to skin surface. Herein, tissue adhesive consisting polyacrylamide/polydopamine (PAM/PDA) embedded with extra‐large pore mesoporous silica nanoparticles (XL‐MSNs) proposed synergy cohesive and properties. The incorporation XL‐MSNs leads enhanced strength due an increased property derived from molecular interactions between...
Over the past decade, mesoporous silica nanoparticles (MSNs) smaller than 200 nm with a high colloidal stability have been extensively studied for systemic drug delivery. Although small molecule delivery via MSNs has successful, encapsulation of large therapeutic biomolecules, such as proteins or DNA, is limited due to pore size conventional obtained by soft-templating. Here, we report synthesis extra-large pores (XL-MSNs) and their application in vivo cytokine macrophage polarization....
Cancer vaccine aims to invoke antitumor adaptive immune responses detect and eliminate tumors. However, the current dendritic cells (DCs)-based cancer vaccines have several limitations that are mostly derived from ex vivo culture of patient DCs. To circumvent limitations, direct activation maturation host DCs using antigen-carrying materials, without need for isolation patients, required. In this study, we demonstrate synthesis extra-large pore mesoporous silica nanoparticles (XL-MSNs) their...
Although reactive oxygen species (ROS) are essential for cellular processes, excessive ROS could be a major cause of various inflammatory diseases because the oxidation proteins, DNA, and membrane lipids. It has recently been suggested that amount thus regulated to treat such physiological disorders. A ROS-scavenging hydrogel is promising candidate therapeutic applications its high biocompatibility, 3D matrix, ability modified. Approaches conferring antioxidant properties normal hydrogels...
Nanotubes of TiO2 and ZrO2 (see Figure) with diameters ca. 30–200 nm have been successfully fabricated by atomic layer deposition in a one-step process utilizing nanoporous membranes (commercial polycarbonate filters) as templates. Sub-angstrom wall thickness control high aspect ratios can be achieved this method.