A5061532156- Genomics, phytochemicals, and oxidative stress
- Inflammatory mediators and NSAID effects
- Heme Oxygenase-1 and Carbon Monoxide
- NF-κB Signaling Pathways
- Sirtuins and Resveratrol in Medicine
- Phytochemicals and Antioxidant Activities
- Estrogen and related hormone effects
- Curcumin's Biomedical Applications
- Glutathione Transferases and Polymorphisms
- Ginger and Zingiberaceae research
- Natural product bioactivities and synthesis
- Cytokine Signaling Pathways and Interactions
- Peroxisome Proliferator-Activated Receptors
- Cancer, Hypoxia, and Metabolism
- Bioactive Compounds and Antitumor Agents
- Helicobacter pylori-related gastroenterology studies
- Eicosanoids and Hypertension Pharmacology
- Bioactive natural compounds
- Carcinogens and Genotoxicity Assessment
- Cancer, Lipids, and Metabolism
- Fatty Acid Research and Health
- Peptidase Inhibition and Analysis
- Cancer Mechanisms and Therapy
- Pharmacological Effects of Natural Compounds
- Immune cells in cancer
Seoul National University
2016-2025
Seoul National University Hospital
2012-2023
Advanced Institute of Convergence Technology
2011-2021
Inha University
2008-2018
University of Hong Kong
2018
University of Macau
2018
Leiden University
2018
University of Kentucky
2018
Universidad Europea del Atlántico
2018
Marche Polytechnic University
2018
Aberrant expression of cyclooxygenase-2 (COX-2) has been implicated in tumor promotion. Resveratrol, a phytoalexin present grapes, was reported to inhibit multistage mouse skin carcinogenesis. In the study, we found that topically applied resveratrol significantly inhibited COX-2 induced by promoter 12- O -tetradecanoylphorbol-13-acetate (TPA). Resveratrol-suppressed phosphorylation and subsequent degradation IκBα, thereby inhibiting activation nuclear factor-κB (NF-κB) TPA-stimulated skin....