A5103273701- Heme Oxygenase-1 and Carbon Monoxide
- Nitric Oxide and Endothelin Effects
- Alcohol Consumption and Health Effects
- Autophagy in Disease and Therapy
- Neonatal Health and Biochemistry
- Endoplasmic Reticulum Stress and Disease
- Eicosanoids and Hypertension Pharmacology
- Cannabis and Cannabinoid Research
- Thermal Regulation in Medicine
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Adipose Tissue and Metabolism
- Immune Response and Inflammation
- Asthma and respiratory diseases
- Phytochemistry and Biological Activities
- Biofield Effects and Biophysics
- Curcumin's Biomedical Applications
- Traditional Chinese Medicine Analysis
- Genomics, phytochemicals, and oxidative stress
- Sirtuins and Resveratrol in Medicine
- NF-κB Signaling Pathways
- Natural product bioactivities and synthesis
- Galectins and Cancer Biology
- Bioactive Compounds and Antitumor Agents
- Neuroinflammation and Neurodegeneration Mechanisms
- Calcium signaling and nucleotide metabolism
Daegu Haany University
2024-2025
University of Ulsan
2014-2023
Jeonbuk National University
1995-2019
Ulsan College
2009-2016
Ulsan University Hospital
2010-2012
Wonkwang University
2001-2010
National Research Foundation of Korea
2010
Gwangju Institute of Science and Technology
2007
Kangwon National University
2007
Bipar
1994-2004
Mitogen-activated protein kinases (MAPKs) are serine-threonine that play the major role in signal transduction from cell surface to nucleus. MAPKs, which consist of growth factor-regulated extracellular signal-related (ERKs), and stress-activated c-jun NH 2 -terminal (JNKs) p38 part a three-kinase signaling module composed MAPK, an MAPK kinase (MAP2K) (MAP3K). MAP3Ks phosphorylate MAP2Ks, turn activate MAPKs. phosphatases (MKPs), recognize TXY amino acid motif present dephosphorylate...
Abstract Heme oxygenase-1 (HO-1) catabolizes heme into CO, biliverdin, and free iron serves as a protective enzyme by virtue of its anti-inflammatory, antiapoptotic, antiproliferative actions. Previously, we have demonstrated that human CD4+ T cells express HO-1 HO-1-overexpressing Jurkat tend to display lower proliferative response. The aim this study is elucidate the mechanism(s) which can mediate effect on cells. Among three byproducts, only CO showed suppressive cell proliferation in...
In this report, we tested the hypothesis that cellular content of non-heme iron determined whether cytotoxic levels nitric oxide (NO) resulted in apoptosis <i>versus</i> necrosis. The consequences NO exposure on cell viability were RAW264.7 cells (a type with low levels) and hepatocytes (cells high content). Whereas micromolar concentrations donor<i>S</i>-nitroso-<i>N</i>-acetyl-dl-penicillamine induced cells, millimolar required to induce necrosis hepatocytes. Caspase-3 activation...
Mitochondrial cytochrome c release plays a critical role in apoptotic signal cascade after the activation of cell surface death receptors. We investigated played by nitric oxide (NO) mitochondrial signaling tumor necrosis factor α (TNF-α) plus actinomycin D (TNF-α/ActD)-induced apoptosis. NO produced either S-nitroso-N-acetyl-DL-penicillamine (SNAP) or inducible synthase (iNOS) prevented TNF-α/ActD-induced apoptosis hepatocytes and also inhibited both caspase-8-like (IETDase) caspase-3-like...
Although nitric oxide (NO) induces neuronal cell death under some conditions, it also can prevent apoptosis resulting from growth factor withdrawal. We investigated the molecular mechanism by which NO protects undifferentiated and differentiated PC12 cells trophic deprivation-induced apoptosis. underwent apoptotic in association with increased caspase-3-like activity, DNA fragmentation, poly(ADP-ribose) polymerase (PARP) cleavage, cytochrome c release after 24 hr of serum The was inhibited...
Fractalkine (FKN) has been implicated in modulation of angiogenesis and vascular inflammation, but the underlying mechanism not elucidated. We have investigated molecular by which FKN regulates angiogenesis. found that recombinant increases vitro proliferation, migration, tube formation human umbilical vein endothelial cells stimulates vivo FKN-induced was accompanied phosphorylation ERK, Akt, nitric oxide (NO) synthase (eNOS), as well an increase NO production. These biochemical events were...
Carbon monoxide (CO), a reaction product of the cytoprotective heme oxygenase (HO)-1, is antiapoptotic in variety models cellular injury, but precise mechanisms remain to be established. In human umbilical vein endothelial cells, exogenous CO activated Nrf2 through phosphorylation protein kinase R-like endoplasmic reticulum (PERK), resulting HO-1 expression. CO-induced activation PERK was followed by eukaryotic translation initiation factor 2alpha and expression activating transcription 4....
IL-1β and TNF-α are important proinflammatory cytokines that respond to mutated self-antigens of tissue damage exogenous pathogens. The endoplasmic reticulum (ER) stress unfolded protein responses related the induction cytokines. However, detailed molecular pathways by which ER mediates cytokine gene expression have not been investigated. In this study, we found stress-induced inositol-requiring enzyme (IRE)1α activation differentially regulates via glycogen synthase kinase (GSK)-3β X-box...
The mechanisms underlying pathophysiological states such as metabolic syndrome and obesity include endoplasmic reticulum (ER) stress aberrant inflammatory responses. ER results from the accumulation of misfolded proteins during conditions. However, precise by which modulates inflammation remain incompletely understood. In this study, we hypothesized that alone could represent a sufficient signal for modulation inflammasome-dependent cytokine We found several stress-inducing chemicals free...
Obesity-induced hepatic lipid accumulation causes lipotoxicity, mitochondrial dysfunction, oxidative stress, and insulin resistance, is implicated in non-alcoholic pathologies such as steatohepatitis fibrosis. Heme oxygenase-1 (HO-1), an important antioxidant enzyme catalyzing the rate-limiting step heme degradation, protects against inflammation, metabolic dysregulation. Here, we demonstrate that phytochemical, quercetin, a natural polyphenol flavonoid, steatosis obese mice fed high-fat...
The immunoresponsive gene 1 (IRG1) protein has crucial functions in embryonic implantation and neurodegeneration. IRG1 promotes endotoxin tolerance by increasing A20 expression macrophages through reactive oxygen species (ROS). cytoprotective heme oxygenase-1 (HO-1), which generates endogenous carbon monoxide (CO), is expressed the lung during Lipopolysaccharide (LPS) cross tolerance. However, detailed molecular mechanisms functional links between HO-1 innate immune system remain unknown. In...
Nonalcoholic fatty liver disease (NAFLD), the hepatic manifestation of metabolic syndrome, has emerged as one most common causes chronic in developed countries over last decade. NAFLD comprises a spectrum pathological changes, including steatosis, steatohepatitis, advanced fibrosis, and cirrhosis. Autophagy, homeostatic process for protein organelle turnover, is decreased during development NAFLD. Previously, we have shown that carbon monoxide (CO), reaction product heme oxygenase (HO)...
Nitric oxide (NO) functions not only as an important signaling molecule in the brain by producing cGMP, but also regulates neuronal cell apoptosis. The mechanism which NO apoptosis is unclear. In this study, we demonstrated that NO, produced either from donor S-nitroso-N-acetyl-d,l-penicillamine (SNAP) or transfection of synthase, suppressed 6-hydroxydopamine (6-OHDA)-induced PC12 cells inhibiting mitochondrial cytochrome c release, caspase-3 and -9 activation, DNA fragmentation. This...
Prostaglandin E2(PGE2), a major product of cyclooxygenase, has been implicated in modulating angiogenesis, vascular function, and inflammatory processes, but the underlying mechanism is not clearly elucidated. We here investigated molecular by which PGE 2 regulates angiogenesis. Treatment human umbilical vein endothelial cells (HUVEC) with increased phosphorylation Akt nitric oxide synthase (eNOS), eNOS activity, (NO) production activation cAMP-dependent protein kinase (PKA)...