A5074311299- Neuroinflammation and Neurodegeneration Mechanisms
- Liver Disease Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Neuroscience and Neuropharmacology Research
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Sirtuins and Resveratrol in Medicine
- Mitochondrial Function and Pathology
- Asthma and respiratory diseases
- Autophagy in Disease and Therapy
- Biochemical effects in animals
- Peroxisome Proliferator-Activated Receptors
- Glycosylation and Glycoproteins Research
- Diet, Metabolism, and Disease
- Diet and metabolism studies
- Clusterin in disease pathology
- Alzheimer's disease research and treatments
- Neuroendocrine regulation and behavior
- Heme Oxygenase-1 and Carbon Monoxide
- 14-3-3 protein interactions
- Regulation of Appetite and Obesity
- Galectins and Cancer Biology
- Stress Responses and Cortisol
- Acute Kidney Injury Research
- Lipid metabolism and disorders
Gyeongsang National University
2016-2025
Gyeongsang National University Hospital
2017-2020
Yale University
2016
Convergence
2015
National Institute of Health Sciences
2011
Institute of Neurobiology
2011
Korea National Institute of Health
2004
Obesity-induced diabetes is associated with chronic inflammation and considered a risk factor for neurodegeneration. We tested the hypothesis that an AMP-activated protein kinase activator, resveratrol (RES), which known to exert potent anti-inflammatory effects, would attenuate peripheral central improve memory deficit in mice fed high-fat diet (HFD). C57BL/6J were HFD or supplemented RES 20 weeks. Metabolic parameters serum evaluated, Western blot analysis immunohistochemistry organs brain...
Abstract Non-alcoholic fatty liver disease (NAFLD) is one of the most frequent causes and its prevalence a serious growing clinical problem. Caloric restriction (CR) commonly recommended for improvement obesity-related diseases such as NAFLD. However, effects CR on hepatic metabolism remain unknown. We investigated metabolic dysfunction in obese diabetic db/db mice. found that mice reverted insulin resistance, steatosis, body weight adiposity to those db/m 1 H-NMR- UPLC-QTOF-MS-based...
Background and Aims: In obesity type 2 diabetes mellitus, leptin promotes insulin resistance contributes to the progression of NASH via activation hepatic stellate cells (HSCs). However, pathogenic mechanisms that trigger HSC in leptin‐deficient are still unknown. This study aimed determine how HSC‐targeting lipocalin‐2 (LCN2) mediates transition from simple steatosis NASH. Approach Results: Male wild‐type (WT) ob/ob mice were fed a high‐fat diet (HFD) for 20 weeks establish an animal model...
Lipocalin-2 (LCN2) is an acute-phase protein that regulates inflammatory responses to bacteria or lipopolysaccharide (LPS).Although the bacteriostatic role of LCN2 well studied, function in acute lung damage remains unclear.Here, knockout (KO) mice were used investigate LPS-treated with without recombinant (rLCN2).In addition, we employed patients pneumonia.RAW264.7 cells given inhibition rLCN2 iron chelator deferiprone.LCN2 KO had a higher survival rate than wild-type (WT) after LPS...
Intermittent fasting (IF), an alternating pattern of dietary restriction, reduces obesity-induced insulin resistance and inflammation. However, the crosstalk between adipose tissue hippocampus in diabetic encephalopathy is not fully understood. Here, we investigated protective effects IF against neuroinflammation cognitive impairment high-fat diet(HFD)-fed mice. Histological analysis revealed that reduced crown-like structures adipocyte apoptosis HFD In addition to circulating lipocalin-2...
Although leptin-deficient ob/ob mice have been investigated to determine whether hepatic steatosis promotes susceptibility hepatotoxic insults, carbon tetrachloride (CCl4)-induced fibrosis in remains largely unknown. In this study, we evaluate the pathogenic mechanisms of CCl4-treated wild-type (WT) and analyze some parameters related lipogenesis, inflammation, fibrosis, oxidative stress, apoptosis, autophagy. CCl4 treatment attenuated liver weight lipogenesis mice. Increased...
Abstract Chitinase 3‐like 1 (CHI3L1) is a secreted glycoprotein that has pleiotropic activity in aggressive cancers. In our study, we examined the expression and function of CHI3L1 glioma cells. was highly expressed human tissue, whereas its normal brain tissue very low. suppression by shRNA reduced cell invasion, anchorage‐independent growth increased death triggered several anticancer drugs, including cisplatin, etoposide doxorubicin, overexpression had opposite effect Because invasive...
Abstract. Purpose: Vessel leakage and loss of pericytes are early signs diabetic retinopathy (DR), which leads to vision loss. Upregulation the vascular endothelial growth factor (VEGF) during diabetes plays a key role in mediating these lesions. The aim this study is investigate effects resveratrol, natural plant‐derived phytoalexin, on damage VEGF induction mouse retinas diabetes. Methods: Diabetes was induced C57BL/6 mice by five consecutive‐intraperitoneal injections 55 mg/kg...
Rhabdomyolysis-induced acute kidney injury (AKI) accounts for about 10 to 40% of all cases AKI. It is known that N-acetylcysteine (NAC) effective in various experimental renal models; however, little information available the rat model glycerol-induced rhabdomyolysis. In this study, we hypothesize NAC plays a renoprotective role via anti-apoptotic pathway.Male Sprague-Dawley rats were divided into four groups: (i) saline control group, (ii) NAC-treated group (N-acetylcysteine) (150 mg/kg),...
Cisplatin has multiple cellular targets and modes of action that lead to nephrotoxicity. This suggests novel therapies act at cisplatin target sites may be effective. We tested whether human adipose tissue-derived mesenchymal stem cells (Ad-MSCs) can affect protect against cisplatin-induced kidney damage. Rats were divided into four groups: control, infused with Ad-MSCs, injected cisplatin, followed by infusion Ad-MSCs. Animal survival renal function decreased histological damage was...
The brain levels of glutamate (Glu) and glutamine (Gln) are partially regulated through the Glu-Gln cycle. Astrocytes play a role in regulating cycle, loss astrocytes has been associated with depressive disorders. We hypothesized that Glu Gln would be affected by astrocyte dysregulation cycle depressive-like behaviours closely related to level changes Gln.We used liquid chromatography measure concentrations prefrontal cortex male mice infused L-α aminoadipic acid (L-AAA), specific toxin,...
AMP-activated protein kinase (AMPK), an enzyme involved in energy homeostasis, regulates inflammatory responses, but its precise mechanisms are not fully understood.Recent evidence has shown that resveratrol (RES), AMPK activator, reduces prostaglandin E 2 production lipopolysaccharide (LPS)-treated microglia.Here, we examined the effect of RES on nuclear factor kappa B (NF-κB) dependent cyclooxygenase (COX)-2 activation LPS-treated RWA 264.7 macrophages.We found treatment with increased...
Graphical abstractAbstractBackground & AimsNon-alcoholic fatty liver disease (NAFLD) contributes to impaired glucose tolerance, leading type 2 diabetes (T2D); however, the precise mechanisms and target molecules that are involved remain unclear. Activating transcription factor 3 (ATF3) is associated with β-cell dysfunction induced by severe stress signals in T2D. We aimed explore exact functional role of ATF3 as a mechanistic link between hepatic steatosis T2D development.MethodsZucker...
Abstract Sterol regulatory element-binding protein (SREBP)-1c is involved in cellular lipid homeostasis and cholesterol biosynthesis highly increased nonalcoholic steatohepatitis (NASH). However, the molecular mechanism by which SREBP-1c regulates hepatic stellate cells (HSCs) activation NASH animal models patients have not been fully elucidated. In this study, we examined role of regulation LCN2 gene expression. Wild-type knockout (1cKO) mice were fed a high-fat/high-sucrose diet, treated...
Caffeine is the most commonly ingested methylxanthine and has anti-cancer effects in several types of cancer. In this study, we examined caffeine on gliomas, both vitro vivo. vitro, treatment reduced glioma cell proliferation through G(0)/G(1)-phase cycle arrest by suppressing Rb phosphorylation. addition, induced apoptosis caspase-3 activation poly(ADP-ribose) polymerase (PARP) cleavage. also phosphorylated serine 9 glycogen synthase kinase 3 beta (GSK3β). Pretreatment with H89, a...
A beneficial radioprotective agent has been used to treat the radiation-induced lung injury. This study was performed investigate whether curcumin, which is known have anti-inflammatory and antioxidant properties, could ameliorate pulmonary inflammation fibrosis in irradiated lungs. Rats were given daily doses of intragastric curcumin (200 mg/kg) prior a single irradiation for 8 weeks after radiation. Histopathologic findings demonstrated that macrophage accumulation, interstitial edema,...
Clusterin (CLU), a glycoprotein, is involved in apoptosis, producing two alternatively spliced isoforms various cell types. The pro-apoptotic CLU appears to be nuclear isoform (nuclear clusterin; nCLU), and the secretory (sCLU) thought anti-apoptotic. detailed molecular mechanism of nCLU as molecule has not yet been clear. In current study, overexpressed induced apoptosis human kidney cells. Biochemical studies revealed that sequestered Bcl-XL via putative BH3 motif C-terminal coiled coil...
Kainic acid (KA)-induced excitotoxicity promotes cytoplasmic calcium accumulation, oxidative stress, and apoptotic signaling, leading to hippocampal neuronal death. Mitochondria play a critical role in neuroinflammation the stress response. Mitochondrial morphology is disrupted during KA-induced seizures; however, it not clear whether mitochondrial fission or fusion factors are involved death.We investigated effect of Mdivi-1, chemical inhibitor protein Drp1, on function KA-injected mice....