A5011798225- Heme Oxygenase-1 and Carbon Monoxide
- Nitric Oxide and Endothelin Effects
- Eicosanoids and Hypertension Pharmacology
- Advanced Glycation End Products research
- Berberine and alkaloids research
- Alcohol Consumption and Health Effects
- Receptor Mechanisms and Signaling
- Plant-based Medicinal Research
- Aldose Reductase and Taurine
- Cardiac Ischemia and Reperfusion
- Inflammatory mediators and NSAID effects
- NF-κB Signaling Pathways
- Peroxisome Proliferator-Activated Receptors
- Cannabis and Cannabinoid Research
- Cell Adhesion Molecules Research
- Adenosine and Purinergic Signaling
- Phytochemicals and Antioxidant Activities
- Traditional Chinese Medicine Analysis
- Neuroscience and Neuropharmacology Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Cell death mechanisms and regulation
- Synthesis and Biological Activity
- Magnolia and Illicium research
- Anesthesia and Sedative Agents
- Neuroscience of respiration and sleep
Gyeongsang National University
2010-2019
Dongguk University
2016
Texas A&M University System
2010
Kyoto Prefectural University of Medicine
2002-2009
Konkuk University
2007-2009
Seoul National University
1984-2008
Pusan National University
2008
Chungnam National University
2008
CHA University
2007
Catholic University of Korea
2007
We examined our hypothesis that heme-oxygenase-1 (HO-1)-derived carbon monoxide (CO) inhibits the release of high-mobility group box 1 (HMGB1) in RAW264.7 cells activated with lipopolysaccharide (LPS) vitro and LPS- or cecal ligation puncture (CLP)-induced septic mice vivo, so HO-1 induction CO improves survival sepsis rodents. found pretreatment inducers (hemin, cobalt protoporphyrin IX) transfection significantly inhibited HMGB1 release, which was blocked by small interfering RNA, LPS....
Hyperglycemia, abnormal lipid and antioxidant profiles are the most usual complications in diabetes mellitus. Thus, this study, we investigated anti-diabetic anti-oxidative effects of anthocyanins (ANT) from black soybean seed coats streptozotocin (STZ)-induced diabetic rats. The administration ANT markedly decreased glucose levels improved heart hemodynamic function (left ventricular end diastolic pressure, +/-dp/dt parameters). not only enhanced STZ-mediated insulin level decreases, but...
BACKGROUND AND PURPOSE Recently, metformin, a well‐known anti‐diabetic drug, has been shown to possess anti‐inflammatory activities. This study investigated the effect of metformin on expression pro‐inflammatory cytokines including high mobility group box 1 (HMGB1) in lipopolysaccharide (LPS)‐treated animals and cells. EXPERIMENTAL APPROACH We whether inhibits release HMGB1 LPS‐treated RAW 264.7 cells increases survival rate endotoxaemic mice (lethal endotoxaemia was induced by an i.p....
We investigated the possible involvement of superoxide (.O2-) radical in alterations vascular reactivity and phosphoinositide (PI) turnover aortas from streptozotocin (STZ)-induced diabetic (4 week) rats. STZ treatment increased maximal contractile response aorta to norepinephrine (NE), phenylephrine (PE) high K+, whereas sensitivity remained unaltered. Ca(++)-induced contractions presence maximally effective concentrations PE K+ were also augmented after treatment. The was associated with...
We examined the inhibition of expression some inflammatory genes associated with ischemia-reperfusion (I/R) injury by anthocyanins isolated from black soybean seed coat in tumor necrosis factor-alpha (TNF-alpha)-treated bovine aortic endothelial cells. In addition, its potential use on I/R-injury was investigated using rats subjected to 30-min occlusion left descending coronary artery followed 24-h reperfusion. Western blot analysis and luciferase activity assay showed that inhibited...
The role of cell adhesion molecules has been studied extensively in the process inflammation, and these are critical components carcinogenesis cancer metastasis. This study investigated effect tanshinone I derived from traditional herbal medicine, Salvia miltiorrhiza Bunge, on expression intercellular molecule-1 (ICAM-1) vascular (VCAM-1) tumor necrosis factor-α (TNF-α)-stimulated endothelial cells. Furthermore, this growth, invasion angiogenesis human breast cells MDA-MB-231, both vitro...
Ultraviolet (UV) radiation can cause inflammatory changes and may further contribute to skin carcinogenesis. Anthocyanins are known be powerful antioxidants that help protect plants from UV damage. Recently, we isolated anthocyanins black soybean [Glycine max (L.) Merr] seed coats. Thus, investigated the protective effect of coats on UVB radiation-induced responses molecular mechanism responsible for regulation apoptosis responses. inhibited UVB-induced cylooxygenase-2 (COX-2) PGE 2...
Abstract Introduction Extracellular nucleotides are released and detectable in a high concentration within the tumor microenvironment. G protein-coupled P2Y 2 nucleotide receptor (P2Y R) is activated equipotently by adenosine triphosphate (ATP) uridine 5′-triphosphate (UTP), which mediate proinflammatory responses such as cell migration proliferation. However, role of R process cancer metastasis remains unclear. This study aimed to determine proliferation, invasion highly metastatic...
AMP-activated protein kinase (AMPK), an enzyme involved in energy homeostasis, regulates inflammatory responses, but its precise mechanisms are not fully understood.Recent evidence has shown that resveratrol (RES), AMPK activator, reduces prostaglandin E 2 production lipopolysaccharide (LPS)-treated microglia.Here, we examined the effect of RES on nuclear factor kappa B (NF-κB) dependent cyclooxygenase (COX)-2 activation LPS-treated RWA 264.7 macrophages.We found treatment with increased...