A5072736258- Catalytic C–H Functionalization Methods
- Synthesis and Catalytic Reactions
- Catalytic Cross-Coupling Reactions
- Cyclopropane Reaction Mechanisms
- Asymmetric Hydrogenation and Catalysis
- Oxidative Organic Chemistry Reactions
- Natural product bioactivities and synthesis
- Drug-Induced Hepatotoxicity and Protection
- Phytochemistry and Biological Activities
- Phytochemical compounds biological activities
- Synthesis of Indole Derivatives
- Genomics, phytochemicals, and oxidative stress
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Bioactive Compounds and Antitumor Agents
- Botany, Ecology, and Taxonomy Studies
- Cholinesterase and Neurodegenerative Diseases
- Liver physiology and pathology
- Bioactive natural compounds
- Sesquiterpenes and Asteraceae Studies
- Catalytic Alkyne Reactions
- Medicinal Plants and Neuroprotection
- Antimicrobial Peptides and Activities
- Chemical Synthesis and Reactions
- Phytochemicals and Antioxidant Activities
Sungkyunkwan University
2014-2023
Kwangshin University
2013-2016
Suwon Research Institute
2014
University of Ulsan
2011
Korea Institute of Science and Technology
1997-2002
Konyang University
2001
University of Oklahoma
2001
A rhodium-catalyzed oxidative acylation of benzamides with aryl aldehydes via direct sp2 C–H bond cleavage is described. In the presence [Cp*RhCl2]2, AgSbF6, and silver carbonate as an oxidant, N,N-diethyl can be effectively carbonylated to yield ortho-acyl benzamides.
Abstract Activatable (turn‐on) probes that permit the rapid, sensitive, selective, and accurate identification of cancer‐associated biomarkers can help drive advances in cancer research. Herein, a NAD(P)H:quinone oxidoreductase‐1 (NQO1)‐specific chemiluminescent probe 1 is reported allows differentiation between subtypes. Probe incorporates an NQO1‐specific trimethyl‐locked quinone trigger moiety covalently tethered to phenoxy‐dioxetane through para ‐aminobenzyl alcohol linker. Bio‐reduction...
The elucidation of the cause Alzheimer's disease remains one greatest questions in neurodegenerative research. lack highly reliable low-cost sensors to study structural changes key proteins during progression is a contributing factor this insight. In current work, we describe rational design and synthesis two fluorescent BODIPY-based probes, named Tau 1 2. probes were evaluated on molecular surface formed by fibril PHF6 (306VQIVYK311) tau fragment using docking studies provide potential...
A mild, practical and efficient palladium-catalyzed decarboxylative ortho-acylation of O-methyl ketoximes with α-keto acids via C-H bond activation is described. In these reactions, a broad range undergoes the cross-coupling reactions high selectivities good tolerance.
A palladium-catalyzed decarboxylative acylation of phenylacetamides with α-oxocarboxylic acids via C-H bond activation is described. This protocol provides efficient access to a range ortho-acyl phenylacetamides, which can be easily converted 3-isochromanone derivatives.
Palladium-catalyzed decarboxylative acylation of highly substituted indolines with α-keto acids via C–H bond activation is described. This protocol provides efficient access to C7-carbonylated indoles known have diverse biological profiles.
Abstract The rhodium‐catalyzed selective cyanation of CH bonds indolines and indoles with N ‐cyano‐ ‐phenyl‐ para ‐methylbenzenesulfonamide is described. This protocol offers a facile access to C‐7 cyanated C‐2 high site selectivity excellent functional group tolerance. magnified image
The rhodium(III)-catalyzed direct C–H functionalization of azobenzenes with ethyl glyoxalate and aryl glyoxals is described. This protocol provides the facile efficient formation various C3-acylated-(2H)-indazoles in moderate to high yields.
The ruthenium-catalyzed oxidative allylation of aromatic and α,β-unsaturated carboxamides with allylic carbonates is described. These transformations proceed readily complete linear γ-selectivity substituted carbonates.
The rhodium(III)-catalyzed direct allylation of indolines with allylic carbonates at room temperature is described. These transformations provide the facile and efficient construction C7-allylated indolic scaffold.
Polyphenolic compounds present in green tea, particularly catechins, are known to have strong anti-influenza activity. The goal of this study was determine whether tea by-products could function as an alternative common antivirals animals compared original tea. Inhibition viral cytopathic effects ascertained by neutral red dye uptake examined with 50% effective (virus-inhibitory) concentrations (EC50) determined. Against the H1N1 virus A/NWS/33, we found activity (EC50 = 6.36 µg/mL) be...
Abstract A palladium‐catalyzed ortho ‐acylation of N ‐benzyltriflamides with aldehydes via direct sp 2 CH bond activation is described. Benzylamines a triflamide directing group in the presence palladium acetate, acetic acid, and tert ‐butyl hydroperoxide as an oxidant can be effectively coupled aryl alkyl to provide ‐acyl‐ high regioselectivity.
Abstract A palladium‐catalyzed oxidative acylation of O ‐phenyl carbamates with α‐oxocarboxylic acids via selective aromatic CH bond activation is described. This protocol represents the first ortho ‐acylation phenol derivatives, and a catalytic amount triflic acid additive crucial for this transformation.
The rhodium-catalyzed oxidative C2-olefination of indoles and pyrroles containing <italic>N</italic>-arylcarboxamide directing groups with a range alkenes subsequent cleavage is described.
The rhodium-catalyzed oxidative alkenylation of<italic>N</italic>-benzyltriflamides with olefins followed by an intramolecular cyclization<italic>via</italic>C–H bond activation is described.
Pulmonary fibrosis is a chronic lung disease characterized by abnormal accumulation of the extracellular matrix (ECM). Chronic damage alveolar epithelium leads to process called "epithelial-mesenchymal transition" (EMT) and increases synthesis deposition ECM proteins. Therefore, inhibition EMT might be promising therapeutic approach for treatment pulmonary fibrosis. β-Sitosterol one most abundant phytosterols in plant kingdom major constituent corn silk, which derived from stigma style maize...
Hepatic fibrosis, characterized by persistent deposition of extracellular matrix (ECM) proteins, occurs in most types chronic liver disease.The prevention damage using extract Dendropanax morbifera has been widely studied, but its molecular mechanism on the therapeutic efficacy hepatic fibrosis is unclear.The aim this study was to assess whether aquatic (DM) D. ameliorates thioacetamide (TAA)-induced fibrosis.Hepatic induced an intraperitoneal (i.p.) injection (150 mg/kg, twice per week) TAA...
Hepatic fibrosis results from overproduction and excessive accumulation of extracellular matrix (ECM) proteins in hepatocytes.Although the beneficial effects dendropanoxide (DPx) isolated Dendropanax morbifera have been studied, its role as an anti-fibrotic agent remains elucidated.We investigated protective effect DPx BALB/C mice that received thioacetamide (TAA) intraperitoneally for 6 weeks.Later (20 mg/kg/day) or silymarin (50 was administered daily weeks, followed by biochemical...