A5101447296- Meteorological Phenomena and Simulations
- Precipitation Measurement and Analysis
- Hippo pathway signaling and YAP/TAZ
- International Maritime Law Issues
- Climate variability and models
- Arctic and Russian Policy Studies
- Atmospheric chemistry and aerosols
- Cellular Mechanics and Interactions
- Coastal and Marine Management
- Ubiquitin and proteasome pathways
- Metabolism, Diabetes, and Cancer
- Wind and Air Flow Studies
- Microtubule and mitosis dynamics
- Cancer-related Molecular Pathways
- Atmospheric aerosols and clouds
- Hydrological Forecasting Using AI
- Protein Kinase Regulation and GTPase Signaling
- Air Quality Monitoring and Forecasting
- Diabetes Treatment and Management
- Atherosclerosis and Cardiovascular Diseases
- Soil Moisture and Remote Sensing
- Drug-Induced Hepatotoxicity and Protection
- Atmospheric and Environmental Gas Dynamics
- Neuropeptides and Animal Physiology
- Liver Disease Diagnosis and Treatment
National Institute of Meteorological Sciences
2009-2024
Chungbuk National University
2006-2022
Korea Meteorological Administration
2010-2022
Seoul National University Hospital
2021
National Institute of Environmental Research
2004-2021
Sungkyunkwan University
2018-2019
Roswell Park Comprehensive Cancer Center
2015
University of Suwon
2013
Korea Maritime and Ocean University
2007-2011
Gyeongsang National University Hospital
2010
Runx2/Cbfa1/Pebp2aA is a global regulator of osteogenesis and crucial for regulating the expression bone-specific genes. Runx2 major target bone morphogenetic protein (BMP) pathway. Genetic analysis has revealed that degraded through Smurf-mediated ubiquitination pathway, its activity inhibited by HDAC4. Here, we demonstrate molecular link between Smurf, HDACs Runx2, in BMP signaling. BMP-2 signaling stimulates p300-mediated acetylation, increasing transactivation inhibiting Smurf1-mediated...
This study demonstrates the characteristics of Weather Research and Forecasting (WRF) Double‐Moment 6‐Class (WDM6) Microphysics scheme for representing precipitating moist convection in 3D platforms, relative to WSM6 that has been widely used WRF community. For a case convective system over Great Plains, WDM6 improves evolutionary features such as bow‐type echo leading edge squall line. We also found with removes spurious oceanic rainfall is systematic defect resulting from use alone. The...
Hepatic fibrosis, characterized by persistent deposition of extracellular matrix (ECM) proteins, occurs in most types chronic liver disease.The prevention damage using extract Dendropanax morbifera has been widely studied, but its molecular mechanism on the therapeutic efficacy hepatic fibrosis is unclear.The aim this study was to assess whether aquatic (DM) D. ameliorates thioacetamide (TAA)-induced fibrosis.Hepatic induced an intraperitoneal (i.p.) injection (150 mg/kg, twice per week) TAA...
The COX-2/PGE2 pathway in hypoxic cancer cells has important implications for stimulation of inflammation and tumourigenesis. However, the mechanism by which glucocorticoid receptors (GRs) inhibit COX-2 during hypoxia not been elucidated. Hence, we explored mechanisms underlying glucocorticoid-mediated inhibition hypoxia-induced human distal lung epithelial A549 cells.The expressions glucocorticoid-induced leucine zipper (GILZ) were determined Western blot and/or quantitative real time-PCR...
Hepatic fibrosis is characterized by persistent deposition of extracellular matrix proteins and occurs in chronic liver diseases. The aim the present study to investigate whether estrogen deficiency (ED) potentiates hepatic a thioacetamide (TAA)-treated rat model. Fibrosis was induced via intraperitoneal injection (i.p.) TAA (150 mg/kg/day) for four weeks ovariectomized (OVX) female, sham-operated or male rats. In TAA-treated OVX rats, activities serum alanine aminotransferase (ALT),...
Mitogen-activated protein kinase/extracellular signal-regulated kinase 1 (MEKK1) is an important component in the stress-activated pathway. Glutathione S-transferase Mu 1-1 (GST M1-1) has now been shown to inhibit stimulation of MEKK1 activity induced by cellular stresses such as UV and hydrogen peroxide. GST M1-1 inhibited activation a manner independent its glutathione-conjugating catalytic activity. In vitro binding assays revealed that directly bound Co-immunoprecipitation analysis...
The mammalian ste20 kinase (MST) signaling pathway plays an important role in the regulation of apoptosis and cell cycle control. We sought to understand MST2 Salvador homolog 1 (SAV1), a scaffolding protein that functions MST pathway, adipocyte differentiation. MST1 stimulated binding SAV1 peroxisome proliferator-activated receptor γ (PPARγ), transcription factor key adipogenesis. interaction endogenous PPARγ was detected differentiating 3T3-L1 adipocytes. This required activity mediated by...
Purpose: Monocyte chemoattractant protein-1 (MCP-1) is a chemokine that can increase adhesion molecule expression on monocytes and produce superoxide anions.Hyperglycemia induces MCP-1 production in vascular endothelial cells retinal pigmented epithelial cells, has been implicated as causal factor the facilitation of complications diabetes.In present study, we evaluated association single nucleotide polymorphism (SNP) gene with proliferative diabetic retinopathy (PDR) Korean population type...
Triclosan (TCS), a common antimicrobial ingredient, is present in many consumer products, including soaps, shampoos, and toothpaste. Owing to its widespread use, potential adverse effects on animals humans may arise from lifetime exposure, but data chronic prepubertal exposure of TCS are still lacking. The aim the study was investigate influence subchronic (0.25, 25, 250, or 750 mg/kg) target organ toxicity male rats. After daily administration rats by oral gavage for 60 d, significant...
One of the critical prerequisites for successful development retinal prostheses is understanding physiological features ganglion cells (RGCs) in different stages degeneration (RD). This study used our custom-made rd10 mice, C57BL/6-Pde6bem1(R560C)Dkl /Korl mutated on Pde6b gene C57BL/6J mouse with CRISPR/Cas9-based gene-editing method. We selected postnatal day (P) 45, P70, P140, and P238 as representative ages RD stages. The optomotor response measured visual acuity across At P45, mice...
The goal of this study was to evaluate the sonographic findings thyroid metastases arising from non-thyroid primaries. over a 5-year period comprised nine patients who had histopathologically proven metastatic disease thyroid. Ultrasonography available in all cases. Ultrasound-guided needle aspiration performed on 10 suspected nodules as determined by ultrasound. Ultrasonographic were analyzed two different ways. first analysis included only those biopsed, and second nodules, biopsed...
The mammalian ste20-like kinase (MST) pathway is important in the regulation of apoptosis and cell cycle emerges as a novel tumor suppressor pathway. MST-induced phosphorylation Salvador homolog 1 (SAV1), which scaffold protein, has not been evaluated detail. We performed mass spectrometric analysis SAV1 protein that was co-expressed with MST2. Phosphorylation detected at Thr-26, Ser-27, Ser-36 Ser-269. Although single or double mutations had little effects, mutation all four residues to Ala...
The Weather Research and Forecasting (WRF) Double-Moment 7-Class (WDM7) cloud microphysics scheme was developed to parameterize precipitation processes explicitly for mesoscale phenomena in the Korean Integrated Model system. However, WDM7 has not been evaluated any precipitating convection system over peninsula. This study modified simulated during summer winter. suggested modifications included integration of new fall velocity–diameter relationship raindrops mass-weighted terminal velocity...