A5024093562- Ginseng Biological Effects and Applications
- Natural product bioactivities and synthesis
- Pharmacological Effects of Natural Compounds
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Metal complexes synthesis and properties
- Food Quality and Safety Studies
- Phytochemicals and Antioxidant Activities
- Phytoestrogen effects and research
- Metal-Organic Frameworks: Synthesis and Applications
- Supramolecular Chemistry and Complexes
- Phytochemistry and Biological Activities
- Adipokines, Inflammation, and Metabolic Diseases
- Natural Antidiabetic Agents Studies
- Phytochemical compounds biological activities
- Phytochemistry and Bioactive Compounds
- Medicinal Plants and Neuroprotection
- Bone Metabolism and Diseases
- Herpesvirus Infections and Treatments
- Liver Disease Diagnosis and Treatment
- Genomics, phytochemicals, and oxidative stress
- melanin and skin pigmentation
- Drug-Induced Hepatotoxicity and Protection
- Plant tissue culture and regeneration
- Essential Oils and Antimicrobial Activity
Kyung Hee University
2016-2025
St. Vincent's Hospital
2023
Korea University
2022
Gachon University
2012-2016
Soonchunhyang University
2015-2016
Yong In University
2016
Government of the Republic of Korea
2015-2016
Life University
2013-2016
University of Ulsan
2013-2014
Semyung University
2009-2012
Two novel nano-cage compounds, 8 and 9, were prepared by self-assembly of the ruthenium complexes 4 5, tripodal donor 1. The cytotoxicity was found to be considerably stronger than that cisplatin. complex inhibited tumor cell proliferation interfering into regulatory pathways cycleviaapoptosis.
Abstract The coordination‐driven self‐assembly of N‐donor ligands with dinuclear arene–ruthenium building blocks has allowed the construction a wide range cationic supramolecules different architectures and functionalities. These include (1) hexacationic molecular metallaprisms in which size cycle type acceptor organic linker influence antitumor behavior resulting self‐assembly, (2) tetracationic metallarectangles, have host–guest capabilities allow sensing biological properties. This report...
It has previously been reported that cold water-extracts of Moringa oleifera leaf have anticancer activity against various human cancer cell lines, including non‑small lung cancer. In the present study, M. extracts was investigated in hepatocellular carcinoma HepG2 cells. By analysis apoptotic signals, induction caspase or poly(ADP‑ribose) polymerase cleavage, and Annexin V terminal deoxynucleotidyl transferase‑mediated dUTP nick end labeling assays, it demonstrated induce apoptosis hollow...
Obesity is characterized by hypertrophy and/or the differentiation or adipogenesis of pre-existing adipocytes. In this study, we investigated inhibitory effects theobromine, a type alkaloid in cocoa, on adipocyte 3T3-L1 preadipocytes and its mechanisms action. Theobromine inhibited accumulation lipid droplets, expression PPARγ C/EBPα, mRNA aP2 leptin. The inhibition adipogenic theobromine occurred primarily early stages differentiation. addition, arrested cell cycle at G0/G1 phase regulated...
The phthalates are ubiquitous industrial plasticizers and include agents such as di(2-ethylhexyl) phthalate (DEHP), dibutyl (DBP), butyl benzyl (BBP), which classified endocrine disruptors because of their anti-androgenic or pro-estrogenic effects. A recent study suggested that DBP produced the hypomethylation c-myc protooncogene in mouse liver to activate c-myc. In present study, DNA at promoter region estrogen receptor alpha (ERalpha) gene was investigated by methylation-specific...
A suite of eight cationic, tetra-metallic molecular rectangles (1–8) was generated via coordination-driven self-assembly using four dicarboxylate-bridged arene-Ru precursors (A1–A4) with one two dipyridyl ligands (D1, D2). The high-yielding (84–92%) were characterized by 1H NMR and HR-ESI-MS to support their structural assignments. structure 5 determined single crystal X-ray analysis, which indicated that D2 bridge A1 acceptors form a rectangular construct. photophysical properties these...
Fucoidan is an l-fucose-enriched sulfated polysaccharide isolated from brown algae and marine invertebrates. In this study, we investigated the protective effect of fucoidan Fucus vesiculosus on alcohol-induced murine liver damage. Liver injury was induced by oral administration 25% alcohol with or without (30 mg/kg 60 mg/kg) for seven days. Alcohol increased serum aspartate aminotransferase alanine levels, but these increases were suppressed treatment fucoidan. Transforming growth factor...
Obesity is a metabolic disorder developed by overnutrition and major cause for insulin resistance cardiovascular events. Since adipose tissue one of the sites synthesis secretion cytokines, enlarged in obese condition alters inflammatory state leading to pathophysiological conditions such as type 2 diabetes increased risk. A plausible theory development dysregulation that obesity increases cytokines from causes chronic inflammation whole body. Additionally accumulation lipids non-adipose...
The synthesis of new 2+2 metalla-rectangles via coordination driven self-assembly octahedral Ru(II) based acceptors and amide donors is described. To evaluate their in vitro cytotoxic properties, preliminary biological assays were carried out for various human cancer cell lines, our results show that the cytotoxicity level 3 comparable or even greater cases SK-hep-1 HCT-15 than reference drug cisplatin.
Abstract A suite of three tetraruthenium metallacycles have been obtained from [2+2] self‐assemblies between N , N′ ‐Di‐(4‐pyridyl)‐1,4,5,8‐naphthalenetetracarbo–xydiimide ( 4 ) and one the dinuclear arene ruthenium clips, (η 6 ‐ p i PrC H Me) 2 Ru OO∩OO )][OTf] =oxalate 1 2,5‐dioxydo‐1,4‐benzoquinonato (dobq) 5,8‐dihydroxy‐1,4‐naphthaquinonato (donq) 3 ; OTf=triflate). All complexes were isolated in good yield (>85 %) as triflate salts fully characterized by using NMR UV/Vis...
A series of supramolecular rectangles, including two mixed-metal Ru/Pt complexes, have been formed by the coordination-driven self-assembly a range arene–Ru "molecular clip" acceptors (1a–1d) with rigid dipyridyl-based ligands (2a–2d) over course 10 h in solution. The isolated products were characterized multinuclear NMR (1H and 13C or 31P), HR-ESI-MS, an X-ray diffraction study to support ascribed two-component rectangular structures. rectangles further UV–vis fluorescence studies. redox...
Sixteen arene–Ru based molecular-rectangles were self-assembled in high yields by the equimolar mixing of acceptors (Aa–Ad) with various azopyridyl ligands (1,2-di(pyridyl-4yl)diazene (L1), 1,2-bis(pyridin-4-ylmethylene)hydrazine (L2), 1,2-bis(1-(pyridin-4-yl)ethylidene)hydrazine (L3), (L4)) nitromethane–methanol solutions. These new fully characterized a host analytical techniques including elemental analysis, 1H and 13C NMR HR-ESI-MS. The solid-state structures two (1b 4d) determined...
Angelica gigas (AG) is effective against various medical conditions such as bacterial infection, inflammation, and cancer. It contains a number of coumarin compounds the group interest pyranocoumarin, which comprises decursin decursinol angelate. This has an effect on controlling caused by excessive nitric oxide (NO) production. Heme oxygenases (HOs), particularly HO-1, play role in regulating production NO. Thus, this study aimed to investigate anti-inflammatory effects AG measuring HO-1...
The two new large molecular metalla-rectangles 6 and 8 were obtained by the reaction of different arene–ruthenium acceptors [Ru2(p-cymene)2(μ-η4-C2O4)Cl2] (2) [Ru2(p-cymene)2(donq)(Cl)2] (donq = 5,8-dioxido-1,4-naphthoquinonato) (4) with a symmetrical N,N′-bis(4-(pyridin-4-ylethynyl)phenyl)terephthalamide (1) donor ligand. Both isolated in good yields as triflate salts characterized multinuclear NMR, ESI–MS, UV–vis spectroscopy. X-ray crystallography confirmed metalla-rectangle....
The antiallergic potential of Arctium lappa L. was investigated in Sprague–Dawley rats, ICR mice, and RBL-2H3 cells. Ethanol extract (90%) A. (ALE, 100 μg/mL) inhibited the degranulation rate by 52.9%, determined level β-hexosaminidase. ALE suppressed passive cutaneous anaphylaxis (PCA) rats attenuated histamine release mice. To identify active compound ALE, we subsequently fractionated β-hexosaminidase all subfractions. Oleamide identified as an which secretion production tumor necrosis...
Three new cobalt-ruthenium heterometallic molecular rectangles, 1-3, were synthesized through the coordination-driven self-assembly of a cobalt sandwich donor, (η5 -Cp)Co[C4 -trans-Ph2 (4-Py)2 ] (L; Cp: cyclopentyl; Py: pyridine), and one three dinuclear precursors, [(p-cymene)2 Ru2 (OO∩OO)2 Cl2 [OO∩OO: oxalato (A1 ), 5,8-dioxido-1,4-naphthoquinone (A2 or 6,11-dioxido-5,12-naphthacenedione (A3 )]. All self-assembled architectures isolated in very good yield (92-94 %) fully characterized by...