A5007744446- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical Economics and Policy
- Pharmaceutical Practices and Patient Outcomes
- Pharmacy and Medical Practices
- Rheumatoid Arthritis Research and Therapies
- Medication Adherence and Compliance
- Pharmaceutical studies and practices
- Biosimilars and Bioanalytical Methods
- Asthma and respiratory diseases
- Pharmacovigilance and Adverse Drug Reactions
- Respiratory and Cough-Related Research
- Lung Cancer Treatments and Mutations
- Liver Disease Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Immune Cell Function and Interaction
- Blood Pressure and Hypertension Studies
- Tuberculosis Research and Epidemiology
- Vaccine Coverage and Hesitancy
- Obesity, Physical Activity, Diet
- Economic and Financial Impacts of Cancer
- Hepatitis C virus research
- Inflammatory mediators and NSAID effects
- Nutrition, Health and Food Behavior
Sungkyunkwan University
2016-2025
Mokpo National University
2023
Creative Commons
2018
Dong-Eui University
2017
Korea Aerospace University
2014
Sookmyung Women's University
2011-2012
Palladium-catalyzed decarboxylative acylation of highly substituted indolines with α-keto acids via C–H bond activation is described. This protocol provides efficient access to C7-carbonylated indoles known have diverse biological profiles.
Ultrasonography (US) is generally recommended for the surveillance of hepatocellular carcinoma (HCC) in patients at risk. However, with cirrhosis who have sufficiently high HCC incidence, using magnetic resonance imaging (MRI) liver-specific contrast showed markedly higher sensitivity detecting early-stage than US. This study aimed to compare cost-effectiveness semiannual MRI versus US compensated and identify population that would gain optimal through surveillance. We designed a Markov...
Objectives Asthma exacerbation, associated with many risks factors, can reflect management failure. However, little is known about how risk factors are according to asthma severity. We aimed investigate differences in patients different severity and evaluate whether differed between frequent exacerbators single exacerbation. Design Nationwide population-based observational study. Setting Korean National Sample Cohort database. Participants included 22 130 adults diagnoses more than twice...
A ketone-assisted ruthenium-catalyzed selective amination of xanthones and chromones C–H bonds with sulfonyl azides is described. The reactions proceed efficiently a broad range substrates excellent functional group compatibility. This protocol provides direct access to 1-aminoxanthones, 5-aminochromones, 5-aminoflavonoid derivatives known exhibit potent anticancer activity.
Objective The cost-effectiveness of antiviral treatment in adult immune-tolerant (IT) phase chronic hepatitis B (CHB) patients is uncertain. Design We designed a Markov model to compare expected costs and quality-adjusted life-years (QALYs) starting at IT-phase (‘treat-IT’) vs delaying the therapy until active (‘untreat-IT’) CHB over 20-year horizon. A cohort 10 000 non-cirrhotic 35-year-old (hepatitis e antigen-positive, mean serum virus (HBV) DNA levels 7.6 log IU/mL, normal alanine...
Proton pump inhibitors (PPIs) are commonly used drugs to relieve gastrointestinal tract symptoms, but their acid-inhibitory action negatively affects the bioavailability and clinical outcomes of orally administered concomitant drugs.To identify patients with advanced breast cancer who concomitantly use PPIs palbociclib.This retrospective cohort study nationwide claims data between November 1, 2016, July 31, 2021, in South Korea. Patients receiving palbociclib 2017, 2020, were identified....
Penpulimab is a PD-1 monoclonal antibody recommended for treating squamous non-small cell lung cancer (sqNSCLC) in combination with paclitaxel and carboplatin. This study aimed to assess the cost-effectiveness of penpulimab combined carboplatin against plus as first-line treatment locally advanced or metastatic sqNSCLC China. A three-state partitioned survival model was constructed using efficacy outcomes obtained by digitizing AK105-302 trial extrapolated lifetime horizon. Data on direct...
Medication errors threaten patient safety by requiring admission, readmission, and/or a longer hospital stay, and can even be fatal. Near-misses indicate the potential for medication to have occurred. Therefore, reporting near-misses is first step in preventing errors. The aim of this study was estimate rate among pharmacists Korean hospitals, identify factors that contributed We surveyed 245 from 32 pharmacies errors, including near-misses. asked them describe their experiences dispensing,...
The chronic disease management program (CDMP), a multilevel intervention including copayment reduction and physician incentives, was introduced in 2012 Korea to improve blood pressure glycemic control by strengthening the function of clinic as primary care institutions managing hypertension diabetes. This study, therefore, aimed evaluate effect CDMP on appropriateness medication adherence persistence or type-2 diabetes patients. A pre-post retrospective study conducted using claims cohort...
Cost-effectiveness is 1 of the most important factors in medicine reimbursement, and social willingness to pay (WTP) can provide evidence for threshold cost-effectiveness analysis. Recently, concept curative medicines has been introduced, so it necessary study their cost-effectiveness. This aimed estimate WTP per quality-adjusted life year (QALY) a cure Korean general population. A total 507 people from population, proportionally assigned by sex, age, region, participated face-to-face...
Mercury is a well-known environmental pollutant that can cause nephropathic diseases, including acute kidney injury (AKI). Although quercetin (QC), natural flavonoid, has been reported to have medicinal properties, its potential protective effects against mercury-induced AKI not evaluated. In this study, the effect of QC was investigated using biochemical parameters, new protein-based urinary biomarkers, and histopathological approach. A 250 mg/kg dose administered orally Sprague-Dawley male...
This study investigated the association between health-related quality of life (HRQoL) and obesity stratified by sex in 34 935 Korean adults. We used data from Korea National Health Nutrition Examination Survey, a cross-sectional, nationwide, population-based survey, 2007 to 2012. Individuals with higher than average health value scores using EQ-5D-3L measure HRQoL were classified as being good health. Multiple logistic regressions determine Of adults, 28.0% (9767) obese, 3.8% (1326)...