A5039560921- Pharmacovigilance and Adverse Drug Reactions
- Diabetes Treatment and Management
- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical Practices and Patient Outcomes
- Drug-Induced Adverse Reactions
- Pregnancy and Medication Impact
- SARS-CoV-2 and COVID-19 Research
- Pneumonia and Respiratory Infections
- Blood Pressure and Hypertension Studies
- COVID-19 Clinical Research Studies
- Rheumatoid Arthritis Research and Therapies
- Vaccine Coverage and Hesitancy
- Bone health and osteoporosis research
- Pharmaceutical studies and practices
- Tuberculosis Research and Epidemiology
- Schizophrenia research and treatment
- Pharmacy and Medical Practices
- Liver Disease Diagnosis and Treatment
- Asthma and respiratory diseases
- Influenza Virus Research Studies
- Bone health and treatments
- Pharmaceutical Economics and Policy
- Gastroesophageal reflux and treatments
- Biosimilars and Bioanalytical Methods
- Long-Term Effects of COVID-19
Sungkyunkwan University
2016-2025
Samsung (South Korea)
2020-2025
Samsung (United Kingdom)
2024
Pohang University of Science and Technology
2024
International Vaccine Institute
2024
McGill University
2015-2023
Korea University
2023
Gachon University
2023
Samsung (India)
2021-2023
Korea University Medical Center
2023
Background: Some data suggest a higher incidence of diagnosis autoimmune inflammatory rheumatic diseases (AIRDs) among patients with history COVID-19 compared uninfected patients. However, these studies had methodological shortcomings. Objective: To investigate the effect on long-term risk for incident AIRD over various follow-up periods. Design: Binational, longitudinal, propensity-matched cohort study. Setting: Nationwide claims-based databases in South Korea (K-COV-N cohort) and Japan...
Global evidence on the association between vaccines and renal adverse events (AEs) is inconclusive. This pharmacovigilance study analyzed a total of 120,715,116 reports from VigiBase collected 1967 2022. We evaluated global reporting acute kidney injury (AKI), glomerulonephritis (GN), tubulointerstitial nephritis (TIN) assessed disproportionate signals AEs using odds ratios (ROR) lower limit 95% confidence interval information component (IC025) in comparison with entire database. The number...
Polypharmacy is widespread in the elderly because of their multiple chronic health problems. The objective this study was to investigate prevalence and predictors associated with polypharmacy a nationally representative sample Korean individuals.We used Korea Health Insurance Review Assessment Service - National Patient Sample (HIRA-NPS) data from 2010 2011. We information on 319,185 patients (aged 65 years or older) between January 1, December 31, 2011 HIRA-NPS database. defined...
To determine whether treatment with methylphenidate in children and young people attention-deficit/hyperactivity disorder (ADHD) was associated cardiovascular events. Self controlled case series analysis. Nationwide health insurance database, 1 January 2008 to 31 December 2011, South Korea. 1224 patients aged ≤17 who had experienced an incident event at least one prescription for methylphenidate. A recorded diagnosis (either a primary or secondary cause) of any the following adverse events:...
The aim of the present study was to describe prescription medications for attention-deficit hyperactivity disorder (ADHD) in UK between 1995 and 2015.Using Clinical Practice Research Datalink (CPRD), we defined a cohort all patients aged 6-45 years, registered with general practitioner January September 2015. All prescriptions methylphenidate, dexamphetamine/lisdexamphetamine atomoxetine were identified annual rates ADHD estimated using Poisson regression.Within 7 432 735 patients, 698 148...
To determine the potential association between use of either glucagon-like peptide-1 receptor agonists (GLP-1RAs) or dipeptidyl peptidase-4 (DPP-4) inhibitors, and risk thyroid cancer in individuals with type 2 diabetes.This population-based cohort study used claims data from Korean National Health Insurance Database, 2014-2020. Two distinct cohorts were established to compare each incretin-based drug sodium-glucose cotransporter-2 (SGLT2) chosen as active comparators because their previous...
Abstract Background Impaired respiratory function remains underrecognized in patients with type 2 diabetes (T2D), despite common pulmonary impairment. Meanwhile, there is little data available on the effects of sodium glucose cotransporter inhibitors (SGLT2i). Hence, we examined association between SGLT2i use and risk adverse events a real-world setting. Methods We conducted population-based, nationwide cohort study using an active-comparator new-user design claims South Korea from January...
Abstract Objective To evaluate the association between antibiotic use during pregnancy or early infancy and risk of neurodevelopmental disorders in children. Design Nationwide population based cohort study sibling analysis. Setting Korea’s National Health Insurance Service mother-child linked database, 2008-21. Participants All children live born 2009 2020, followed up until 2021 to compare those with without exposure (first six months life). Main outcomes measures Autism spectrum disorder,...
To examine the hepatic effectiveness of sodium-glucose cotransporter-2 inhibitors (SGLT-2i) through a head-to-head comparison with glucagon-like peptide-1 receptor agonists (GLP-1RA) or thiazolidinediones (TZD) in patients metabolic dysfunction-associated steatotic liver disease (MASLD).
Relatively little is known about thrombotic adverse events (AEs) of emicizumab in postmarketing real-world settings, particularly comparison with factor VIII (FVIII) products. A recent European study reported a potentially greater risk compared FVIII
Immunization rates of maternal influenza vaccination during pregnancy remain suboptimal, with concerns about potential harm to the mothers and their offspring. We conducted a population‐based cohort study, using mother–child linked database in Korea: (a) between December 2019, March 2022; (b) neonatal September 2020, June 2021. Exposure was defined as pregnancy. Study outcomes included gestational outcomes, vaccine‐related adverse events, other health childbirth immune‐related children....
Despite emerging evidence of gallbladder or biliary tract diseases (GBD) risk regarding incretin-based drugs, population-specific safety profile considering obesity is lacking. We aimed to assess whether stratification by body mass index (BMI) modifies the measures association between drugs and GBD. conducted an active-comparator, new-user cohort study using a nationwide claims data (2013-2022) Korea. included type 2 diabetes (T2D) patients stratified Asian BMI categories: Normal, 18.5 <23...
Abstract Aims There is limited evidence regarding whether obesity modifies the association between use of sodium‐glucose cotransporter 2 inhibitors (SGLT2is) and risk cardiovascular events. We assessed baseline body mass index (BMI) SGLT2i major adverse events (MACE) heart failure (HF) in patients with type diabetes (T2D). Materials Methods used nationwide claims data Korea (September 2014–December 2022) to construct an active‐comparator, new‐user cohort T2D stratified by Asian BMI...
To define the risk of intracranial haemorrhage among patients treated with antidepressants and non-steroid anti-inflammatory drugs (NSAIDs), compared those without NSAIDs.Retrospective nationwide propensity score matched cohort study.Korean health insurance database between 1 January 2009 31 December 2013.Patients who began receiving for first time (index date) a history having received prescription during preceding year. Patients had been diagnosed as cerebrovascular diseases within year...
Elevated serum ferritin has been known to be associated with the prevalence of metabolic syndrome (MetS). However, there was no research examine whether levels have actually prospective development MetS. Accordingly, we carried out a study evaluate longitudinal effects baseline on MetS.A MetS-free cohort 18,022 healthy Korean men, who had participated in medical health checkup program 2005, followed until 2010. MetS defined according joint interim statement International Diabetes Federation...
Background Epidemiological data on the association between mental disorders and risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection disease 2019 (COVID-19) severity are limited. Aims To evaluate SARS-CoV-2 outcomes following COVID-19. Method We performed a cohort study using Korean COVID-19 patient database based national health insurance data. Each person with or behavioural disorder (diagnosed during 6 months prior to their first test) was matched by age, gender...
Background: Adherence to tuberculosis (TB) drugs is one of the key aspects global TB control, yet there a lack epidemiological evidence on factors influencing adherence drugs. Thus, this study aimed explore and associated with among patients in South Korea. Methods: We conducted cohort using sampled national healthcare database from 2017 2018. Our population included incident initiating quadruple or triple regimen who were available for follow-up 180-days. was evaluated proportion days...
Existing observational data have indicated positive associations of acid-suppressive medication (ASM) use in prenatal and early life with allergic diseases children; however, no study to date has accounted for confounding by indication or within-familial factors.
Abstract Disproportionate impact of COVID-19 on socioeconomic and behavioral variables may have impacted the prevalence diabetes. We utilized nationwide long-term serial study from 2009 to 2021 Korea Community Health Survey (KCHS). explored national regional trends diabetes according factors before during pandemic. Also, we interpreted which groups became more vulnerable diagnosed A total 2,971,349 adults aged (19 39, 40 59, ≥ 60 years) were included in analysis. The increased slowly...