A5052152142- Viral gastroenteritis research and epidemiology
- Influenza Virus Research Studies
- Animal Virus Infections Studies
- Virus-based gene therapy research
- Respiratory viral infections research
- Immune Response and Inflammation
- Animal Disease Management and Epidemiology
- Probiotics and Fermented Foods
- Bacteriophages and microbial interactions
- Antimicrobial Peptides and Activities
- Viral Infections and Vectors
- Plant Virus Research Studies
- Microbial infections and disease research
- Olfactory and Sensory Function Studies
- SARS-CoV-2 and COVID-19 Research
- Cytomegalovirus and herpesvirus research
- Vibrio bacteria research studies
- Antimicrobial agents and applications
- Dental Research and COVID-19
- Aquaculture disease management and microbiota
- Listeria monocytogenes in Food Safety
- Zoonotic diseases and public health
- Infection Control and Ventilation
- Viral Infections and Immunology Research
- Infant Nutrition and Health
Konkuk University
2010-2022
Konkuk University Medical Center
2014
Polyphenolic compounds present in green tea, particularly catechins, are known to have strong anti-influenza activity. The goal of this study was determine whether tea by-products could function as an alternative common antivirals animals compared original tea. Inhibition viral cytopathic effects ascertained by neutral red dye uptake examined with 50% effective (virus-inhibitory) concentrations (EC50) determined. Against the H1N1 virus A/NWS/33, we found activity (EC50 = 6.36 µg/mL) be...
Since 2007, 55 adenovirus strains have been isolated from commercial chicken flocks in Korea and identified the pathogenicity of these isolates was confirmed specific-pathogen-free chickens different age. Based on sequencing analysis hexon gene, FAdV were genetically related to IBH-2A strain FAdV3 (4 isolates, 99.2% 100%), KR5 FAdV4 (22 97.9% 99.2%), 764 FAdV9 (11 99.1% 99.3%), 1047 FAdV11 (18 >99%). Experimental infections with four serotypes resulted high mortality 18-day-old embryos...
The purpose of this study was to investigate the distribution Salmonella species in an integrated broiler supply chain Korea. A total 1,214 samples from various steps production company including breeder farms, trucks, slaughterhouse, and retail chicken meats were collected investigated. detected 195 samples. highest prevalence observed transporting trucks (71.43%), followed by slaughterhouse (63.89%) farms (16.05%). Hadar most frequently isolated serotype (83.08%). All isolates investigated...
Live bird markets (LBMs) provide an ideal environment for the evolution and interspecies transfer of avian influenza viruses (AIVs). In this study, we analyzed AIVs present in LBMs Korea during winter seasons 2006–08. Sixty-five that belong to four hemagglutination (HA) subtypes AIV (H3, H4, H6, H9) were isolated from 644 pooled tissue or swab samples collected LBMs. Most H9 Galliformes (chickens, silky fowls, pheasants, guinea fowls), other Anseriformes (Pekin ducks mallards). addition,...
Infectious bronchitis virus (IBV) infections cause great economic losses to the poultry industry worldwide, and emergence of new variant strains complicates disease control. The present study investigated genetic protectotypic features newly emerged Korean IBV strains. A phylogenetic analysis showed that several recent isolates formed 2 different clusters (new cluster 1 2), which were distinct from other preexisting clusters. New represented recombinants between nephropathogenic strain KM91...
A Salmonella Gallinarum (SG)-specific bacteriophage isolated from sewage effluent was used to prevent horizontal transmission of SG in commercial layer chickens. Six-week-old chickens, each challenged with 5 × 108 colony-forming units SG, cohabited contact chickens treated 106 plaque-forming units/kg bacteriophage, prepared feed additives, for 7 days before, and 21 after challenge SG. Mortality observed 3 wk periodically re-isolated the liver, spleen, cecum re-isolation organs decreased a...
Highly pathogenic avian influenza (HPAI) H5N1 virus circulates among a variety of free-ranging wild birds and continually poses threat to animal human health. During the winter 2010–2011, we surveyed Korean bird habitats. From 728 fresh fecal samples, 14 HPAI viruses were identified. The isolates phylogenetically clustered with other recently isolated clade 2.3.2 from in Mongolia. All HPAI-positive samples analyzed by DNA barcoding for host-species identification. Twelve typed as Mandarin...
The aim of this study was to determine whether intranasal administration Lactobacillus sp. could prevent horizontal transmission H9N2 avian influenza virus (AIV) in specific-pathogen-free chickens. Three-week-old chickens received 500 μL 1.5 × 10(9) cfu fermentum CJL-112 strain (CJL) intranasally for 7 d before and 14 after a challenge. Challenged chickens, each inoculated with AIV, were kept either direct or indirect contact naive morbidity viral shedding monitored. We demonstrated that the...
An outbreak of avian influenza, caused by an H9N2 low-pathogenic influenza virus (AIV), occurred in a chicken farm and severe economic losses due to mortality diarrhea. AIV was isolated identified sample from affected native Korean chicken. Genetic analysis the isolate revealed high sequence similarity genes novel reassortant viruses slaughterhouses live bird markets Korea 2008 2009. Animal challenge studies demonstrated that replication kinetics pathogenicity were considerably altered...
Infectious bronchitis virus (IBV) infections cause great economic losses to the poultry industry worldwide. IBVs continuously evolve by developing mutations in antigenic sites; therefore, an IBV vaccine that provides broad cross-protection can be a highly relevant and practical method control strategies. Although some strains are known provide protection against multiple serotypes, general commercially available antigenically related viruses but not distinct heterologous viruses. In present...
Patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of disease 2019, suffer from and non-respiratory symptoms. Among these symptoms, loss smell has attracted considerable attention. The objectives this study were to determine which cells are infected, what happens in olfactory system after viral infection, how pathologic changes contribute loss. For purpose, Syrian golden hamsters used. First, we verified structures nasal cavity hamsters,...
The antiviral effect of a catalytic RNA-hydrolyzing antibody, 3D8 scFv, for intranasal administration against avian influenza virus (H1N1) was described. recombinant scFv protein prevented BALB/c mice H1N1 infection by degradation the viral RNA genome through its intrinsic activity. Intranasal (50 μg/day) five days prior to demonstrated an activity (70% survival) infection. ability penetrate into epithelial cells from bronchial cavity via respiratory mucosal layer confirmed...
Coronavirus disease 2019 (Covid-19) caused by the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) became a pandemic, causing significant burden on public health worldwide. Although timely development and production of mRNA adenoviral vector vaccines against SARS-CoV-2 have been successful, issues still exist in vaccine platforms for wide use production. With potential proliferative capability heat stability, Newcastle virus (NDV)-vectored is highly economical conceivable...
Important Findings Fifty-five fowl adenovirus (FAdV) strains isolated from commercial chicken flocks in the Republic of Korea since 2007 were identified and pathogenicity these isolates was confirmed specific-pathogen-free chickens different age. The study results indicate that four FAdV serotypes (3, 4, 9, 11) are dominant FAdVs pathogenic enough to cause clinical disease young chicks.
This article describes a series of animal studies for the development an avian metapneumovirus (aMPV) live vaccine. Although aMPV causes continual economic loss in poultry industry, there are no vaccines available Korea. Furthermore, information is limited with respect to standard field practices vaccinations at early age. Here, vaccine was attempted, and its efficacy investigated vaccination route age develop method controlling aMPV. Before development, challenge model established using...
Currently, no vaccine or established therapeutic agents are available for coronavirus disease 2019. The sharp increase in demand personal protective equipment (PPE) necessitates an improvement the efficacy of PPE. We evaluated potential antimicrobial and antiviral effects a surface-coating disinfectant (3-(trimethoxysilyl)propyldimethyl octadecyl ammonium chloride, Si-QAC) when applied onto Si-QAC-pre-coated PPE was artificially contaminated with either influenza virus Salmonella. results...