A5067436574- Influenza Virus Research Studies
- Respiratory viral infections research
- Animal Disease Management and Epidemiology
- Educational Research and Pedagogy
- Education, Safety, and Science Studies
- Educational Systems and Policies
- Immune Response and Inflammation
- Animal Virus Infections Studies
- Education and Learning Interventions
- Viral gastroenteritis research and epidemiology
- interferon and immune responses
- SARS-CoV-2 and COVID-19 Research
- Virology and Viral Diseases
- Viral Infections and Vectors
- Probiotics and Fermented Foods
- Mosquito-borne diseases and control
- Diverse Approaches in Healthcare and Education Studies
- Vector-Borne Animal Diseases
- COVID-19 Clinical Research Studies
- Advancements in Transdermal Drug Delivery
- vaccines and immunoinformatics approaches
- Monoclonal and Polyclonal Antibodies Research
- Virus-based gene therapy research
- Respiratory Support and Mechanisms
- Antimicrobial Peptides and Activities
University of Maryland, College Park
2023-2025
Virginia–Maryland College of Veterinary Medicine
2023-2025
Konkuk University
2011-2023
National Institute of Allergy and Infectious Diseases
2015-2022
National Institutes of Health
2015-2022
Cambodia National Malaria Center
2022
National Institute of Biomedical Imaging and Bioengineering
2022
Frederick National Laboratory for Cancer Research
2022
Office of Extramural Research
2019
Georgia Institute of Technology
2008-2018
Lung epithelial and endothelial cell damage defective lung tissue repair contribute to fatal COVID-19.
ABSTRACT Influenza virus hemagglutinin (HA) surface glycoprotein is currently the primary target of licensed influenza vaccines. Recently, broadly reactive antibodies that stalk region HA have become a major focus current novel vaccine development. These been observed in humans after natural infection with A virus, but data are limited. Using samples and from uniquely controlled setting an A/H1N1 human challenge study healthy volunteers, we performed secondary analysis for first time...
The devastating potential of influenza has been well known for over 100 years. Despite the development vaccines since middle 20th century, continues to be responsible substantial global morbidity and mortality. To develop next-generation with enhanced effectiveness, we must synthesize our understanding complex immune mechanisms culminating in protection. Our study outlines differences responses vaccine infection, identifying gaps vaccine-induced immunity, particularly at level nasal mucosa....
Spines are dendritic protrusions that receive most of the excitatory input in brain. Early after onset cerebral ischemia spines peri-infarct cortex replaced by areas focal swelling, and their re-emergence from these varicosities is associated with neurological recovery acute ischemic stroke (AIS). Urokinase-type plasminogen activator (uPA) a serine proteinase plays central role tissue remodeling via binding to urokinase receptor (uPAR). We report cortical neurons release uPA during phase...
Identification of correlates protection against human influenza A virus infection is important in development broadly protective ("universal") vaccines. Certain assumptions underlie current vaccine developmental strategies, including that with a particular should offer long-term or lifelong strain, preventing reinfection. In this study we report observations made when 7 volunteers participated sequential challenge studies where they were challenged intranasally using the identical...
Inhabitants of the Greater Mekong Subregion in Cambodia are exposed to pathogens that might influence serologic cross-reactivity with severe acute respiratory syndrome coronavirus 2. A prepandemic serosurvey 528 malaria-infected persons demonstrated higher-than-expected positivity nonneutralizing IgG spike and receptor-binding domain antigens. These findings could affect interpretation large-scale serosurveys.
Abstract Background Better influenza vaccines are needed, not just for seasonal strains but future pandemic viruses. BPL-1357 is a whole-virus, β-propiolactone-inactivated vaccine containing four wild-type, low-pathogenicity avian viruses (H1N9, H3N8, H5N1, and H7N3). In mice ferrets, provided robust protection against challenge with diverse set of A viruses, including completely heterosubtypic strains. Methods phase 1, randomized, placebo-controlled, double-blinded, study was performed in...
In 2014, the highly pathogenic avian influenza (HPAI) virus H5N8 triggered outbreaks in wild birds and poultry farms South Korea. present study, we investigated pathogenicity of HPAI virus, belonging to clade 2.3.4.4, different species poultry. For this, examined clinical signs viral shedding levels following intranasal inoculation 3-week-old commercial layer chickens quails, 10-week-old Korean native chickens, 8-week-old Muscovy ducks. Intranasal with 10(6.0) viruses at 50% egg-infective...
The purpose of this study was to investigate the distribution Salmonella species in an integrated broiler supply chain Korea. A total 1,214 samples from various steps production company including breeder farms, trucks, slaughterhouse, and retail chicken meats were collected investigated. detected 195 samples. highest prevalence observed transporting trucks (71.43%), followed by slaughterhouse (63.89%) farms (16.05%). Hadar most frequently isolated serotype (83.08%). All isolates investigated...
Influenza A viruses (IAVs) present major public health threats from annual seasonal epidemics and pandemics adapted to a variety of animals including poultry, pigs, horses. Vaccines that broadly protect against all such IAVs, so-called “universal” influenza vaccines, do not currently exist but are urgently needed. Here, we demonstrated an inactivated, multivalent whole-virus vaccine, delivered intramuscularly or intranasally, was protective challenges with multiple IAV hemagglutinin...
ABSTRACT In this study, we developed Newcastle disease virus (NDV) virus-like particles (VLPs) expressing NDV fusion (F) protein along with influenza matrix 1 (M1) using the insect cell expression system. Specific-pathogen-free chickens were immunized oil emulsion VLP vaccines containing increasing dosages of VLPs (0.4, 2, 10, or 50 μg VLPs/0.5-ml dose). Three weeks after immunization, immunogenicity was determined a commercial enzyme-linked immunosorbent assay (ELISA) kit, and lethal...
Epidemics of H3N2 canine influenza virus (CIV) among dogs in South Korea and southern China have raised concern over the potential for zoonotic transmission these viruses. Here, we analysed pathogenesis transmissibility CIV ferret. replicated efficiently respiratory system inoculated ferrets caused acute necrotizing bronchioalveolitis non-suppurative encephalitis. Transmission was detected three six co-housed with ferrets, but no viruses were second-contact ferrets. These findings show that...
Highly pathogenic avian influenza (HPAI) and Newcastle disease (ND) are considered as the most devastating poultry infections, owing to their worldwide distribution economical threat. Vaccines have been widely used control these diseases in industry endemic countries. However, vaccination policy without differentiating infected animals from vaccinated (DIVA) makes virus surveillance difficult. In this study, we developed a bivalent virus-like particle (VLP) vaccine that is composed of...
An outbreak of avian influenza, caused by an H9N2 low-pathogenic influenza virus (AIV), occurred in a chicken farm and severe economic losses due to mortality diarrhea. AIV was isolated identified sample from affected native Korean chicken. Genetic analysis the isolate revealed high sequence similarity genes novel reassortant viruses slaughterhouses live bird markets Korea 2008 2009. Animal challenge studies demonstrated that replication kinetics pathogenicity were considerably altered...
Interferon gamma (IFN-γ), an immunoregulatory cytokine, is known to control many microbial infections. In a previous study, chicken interferon (chIFN-γ) was found be up-regulated following avian influenza virus (AIV) infection in specific pathogen-free chickens. We aimed investigate whether the pre-immune state induced by chIFN-γ could generate antiviral response against virus. generated chIFN-γ-expressing plasmid and transfected it into embryo fibroblasts (CEFs) then infected cells with...