A5049967604- Malaria Research and Control
- Mosquito-borne diseases and control
- Complement system in diseases
- Parasites and Host Interactions
- vaccines and immunoinformatics approaches
- Reproductive Physiology in Livestock
- HIV Research and Treatment
- Invertebrate Immune Response Mechanisms
- Pregnancy and preeclampsia studies
- Research on Leishmaniasis Studies
- Hemoglobinopathies and Related Disorders
- Reproductive Biology and Fertility
- Computational Drug Discovery Methods
- Genetic and phenotypic traits in livestock
- SARS-CoV-2 and COVID-19 Research
- Hepatitis Viruses Studies and Epidemiology
- Trypanosoma species research and implications
- Iron Metabolism and Disorders
- Reproductive System and Pregnancy
- Travel-related health issues
- Global Maternal and Child Health
- Vector-borne infectious diseases
- Monoclonal and Polyclonal Antibodies Research
- COVID-19 Clinical Research Studies
- Immune Cell Function and Interaction
National Institute of Malaria Research
2021-2025
National Institute of Allergy and Infectious Diseases
2015-2024
National Institutes of Health
2015-2024
Mayo Clinic
2014-2024
WinnMed
2023
Center for Infectious Disease Research
2008-2021
University of Washington
2006-2021
Infectious Disease Research Institute
2019-2021
Brown University
2005-2021
University College Dublin
2007-2019
Women are particularly susceptible to malaria during first and second pregnancies, even though they may have developed immunity over years of residence in endemic areas. Plasmodium falciparum- infected red blood cells (IRBCs) were obtained from human placentas. These IRBCs bound purified chondroitin sulfate A (CSA) but not other extracellular matrix proteins or known IRBC receptors. nonpregnant donors did bind CSA. Placental adhered sections fresh-frozen placenta with an anatomic...
Higher systemic progesterone in the immediate post-conception period is associated with an increase embryonic growth rate, interferon-tau production and pregnancy rate cattle. The objective of this study was to examine effect increasing concentration on Day 3 subsequent embryo survival development. Oestrus (Day 0) synchronised beef-cross heifers (n = 210) approximately two-thirds were inseminated semen from a proven sire, while remainder not inseminated. In order produce animals divergent...
In cattle, elevated concentrations of circulating progesterone (P4) in the immediate postconception period are associated with advanced conceptus development, while low P4 is implicated as a causative factor pregnancy rates observed dairy cows. This study aimed to: 1) describe transcriptional changes that occur bovine endometrium during estrous cycle, 2) determine how affects these changes, 3) identify if alters expression genes, and 4) assess impact has on development. Relatively few...
Antibodies that inhibit Plasmodium falciparum adhesion to the placental receptor chondroitin sulfate A are associated with a reduced risk of malaria, but whether these antibodies lead improved pregnancy outcomes is unknown. We measured antiadhesion antibody levels in parturient women western Kenya, where malaria transmission intense. Secundigravid activity their plasma delivered babies were on average 398 g heavier (P = 0.019) and 2 weeks more mature 0.002) than secundigravidas without...
Abstract Pregnant women, especially primigravidas, are highly susceptible to malaria infection, resulting in maternal anemia and low birth weight infants. Because circulating parasitemia is rare the newborn, cause of poor fetal outcomes has been unclear. We measured cytokine concentrations placentas collected from women delivering urban hospitals malaria-holoendemic or nonendemic areas Kenya. Normal displayed a bias toward type 2 cytokines; 1 cytokines IFN-γ IL-2 were absent not exposed but...
Intermittent preventive treatment in pregnancy (IPTp) is used to prevent Plasmodium falciparum malaria. However, parasites resistant the IPTp drug sulfadoxine-pyrimethamine (SP) have emerged worldwide, and infections with mixed susceptible are exacerbated by pyrimethamine mice. In a prospective delivery cohort Muheza, Tanzania, we examined effects of SP on parasite resistance alleles, diversity, level parasitemia, inflammation placenta. use was associated an increased fraction carrying...
In endemic areas, placental malaria due to Plasmodium falciparum is most frequent and severe in first-time mothers, increases the risk of infant mortality their offspring. Placental may increase susceptibility infants parasitemia, but evidence for this effect inconclusive.During 2002-2004, we monitored parasitemia 453 infants, including 69 who were born mothers with malaria, a region northeastern Tanzania where transmission intense. We used Cox proportional hazards model evaluate time from...
(See the article by Maiga et al, on pages 215–223, and editorial commentary Leke Taylor, 231–233.)
At the 2010 Keystone Symposium on "Malaria: new approaches to understanding Host-Parasite interactions", an extra scientific session discuss animal models in malaria research was convened at request of participants. This prompted by concern investigators that skepticism community about use and relevance models, particularly rodent severe malaria, has impacted funding decisions publication using models. Several speakers took opportunity demonstrate similarities between findings human disease,...
Severe Plasmodium falciparum malaria is a major cause of death in children. The contribution the parasite burden to pathogenesis severe has been controversial.
Transmission-blocking vaccines (TBVs) that target sexual stage parasite development could be an integral part of measures for malaria elimination. Pfs25 is a leading TBV candidate, and previous studies conducted in animals demonstrated improvement its functional immunogenicity after conjugation to EPA, recombinant, detoxified ExoProtein A from Pseudomonas aeruginosa. In this report, we describe results open-label, dose-escalating Phase 1 trial assess the safety Pfs25-EPA conjugates...
Novel vaccines are urgently needed to reduce the burden of severe malaria. Using a differential whole-proteome screening method, we identified Plasmodium falciparum schizont egress antigen-1 (PfSEA-1), 244-kilodalton parasite antigen expressed in schizont-infected red blood cells (RBCs). Antibodies PfSEA-1 decreased replication by arresting rupture, and conditional disruption resulted profound defect. Vaccination mice with recombinant berghei PbSEA-1 significantly reduced parasitemia delayed...