A5014373225- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Infectious Diseases and Mycology
- Cystic Fibrosis Research Advances
- Viral Infections and Immunology Research
- Mosquito-borne diseases and control
- Viral gastroenteritis research and epidemiology
- Virology and Viral Diseases
- Pediatric health and respiratory diseases
- Helicobacter pylori-related gastroenterology studies
- COVID-19 epidemiological studies
- Pneumonia and Respiratory Infections
- SARS-CoV-2 and COVID-19 Research
- Parasitic Diseases Research and Treatment
- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Malaria Research and Control
- Parasites and Host Interactions
- Syphilis Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Respiratory viral infections research
- Bacterial Infections and Vaccines
- Antibiotic Use and Resistance
- Tracheal and airway disorders
- Bacterial Identification and Susceptibility Testing
National Institutes of Health
2016-2025
National Institute of Allergy and Infectious Diseases
2016-2025
Office of Extramural Research
2017-2023
Kaiser Permanente
2022
Fisher College
2022
National Institutes of Health Clinical Center
2017-2021
Foundation for the National Institutes of Health
2013-2018
Harvard Pilgrim Health Care
2017
Harvard University
2017
Massachusetts General Hospital
2017
Rationale: Pulmonary nontuberculous mycobacteria (PNTM) are an important cause of morbidity among older adults in the United States, but national prevalence estimates lacking.Objectives: To describe and trends PNTM disease aged 65 years or throughout States.Methods: A nationally representative 5% sample Medicare Part B beneficiaries was analyzed from 1997 to 2007. Demographic medical claims data were compiled for selected comorbidities calculated over time evaluated. Logistic regression used...
Single-site clinic-based studies suggest an increasing prevalence of pulmonary nontuberculous mycobacteria (NTM) disease, but systematic data are lacking.
Resistance to all first-line antibiotics necessitates the use of less effective or more toxic "reserve" agents. Gram-negative bloodstream infections (GNBSIs) harboring such difficult-to-treat resistance (DTR) may have higher mortality than phenotypes that allow for ≥1 active antibiotic.The Premier Database was analyzed inpatients with select GNBSIs. DTR defined as intermediate/resistant in vitro ß-lactam categories, including carbapenems and fluoroquinolones. Prevalence aminoglycoside...
Cryptococcal meningitis (CM) causes significant morbidity and mortality globally; however, recent national trends have not been described. Incidence for CM-associated hospitalizations in 18 states were estimated using the Agency Healthcare Research Quality (AHRQ) State Inpatient Databases (SID) datasets 1997 through 2009. We identified 30,840 coded CM, of which 21.6% among HIV-uninfected patients. CM in-hospital was (12.4% women 10.8% men) with a total 3,440 deaths over study period....
VP1 sequences were determined for poliovirus type 1 isolates obtained over a 189-day period from poliomyelitis patient with common variable immunodeficiency syndrome (a defect in antibody formation). The isolate the first sample, taken 11 days after onset of paralysis, contained two populations, differing Sabin vaccine strain by approximately 10%, diverse wild polioviruses 19 to 24%, and each other 5.5% nucleotides. Specimens day appeared contain only one major population. Evolution at...
Prevalence of pulmonary nontuberculous mycobacterial (PNTM) disease varies by geographic region, yet the factors driving these differences remain largely unknown.To identify spatial clusters PNTM at county level and to describe environmental sociodemographic predictive disease.PNTM cases identified from a nationally representative sample Medicare Part B beneficiaries 1997 2007 were geocoded state residence. County-level case counts population data then uploaded into SaTScan significant...
A national serosurvey was conducted in Mexico from March to October 1986 identify predictors of dengue transmission and target areas at high risk severe annual epidemics. total 3,408 households 70 localities with populations less than 50,000 were randomly sampled, serology obtained one subject under age 25 years each household. When comparing exposure infection frequencies across the communities, authors found that median temperature during rainy season strongest predictor infection, an...
Rationale: Treatment of pulmonary nontuberculous mycobacteria, especially Mycobacterium abscessus, requires prolonged, multidrug regimens with high toxicity and suboptimal efficacy. Options for refractory disease are limited.Objectives: We reviewed the efficacy inhaled amikacin in patients treatment-refractory mycobacterial lung disease.Methods: Records were queried to identify who had added failing regimens. Lower airway microbiology, symptoms, computed tomography scan changes assessed...
Rationale: The clinical features of patients infected with pulmonary nontuberculous mycobacteria (PNTM) are well described, but the genetic components infection susceptibility not.Objectives: To examine variants in PNTM, their unaffected family members, and a control group.Methods: Whole-exome sequencing was done on 69 white PNTM 18 members. We performed candidate gene analysis using immune, cystic fibrosis transmembrance conductance regulator (CFTR), cilia, connective tissue sets. numbers...
Abstract The prevalence and trends of pulmonary nontuberculous mycobacteria (NTM)–associated hospitalizations in the United States were estimated using national hospital discharge data. Records extracted for all persons with a NTM International Classification Diseases code (031.0) hospitalized 11 states continuous data available from 1998 through 2005. Prevalence was calculated US census Pulmonary increased significantly age among both sexes: relative 70–79 years compared those 40–49...
Pulmonary nontuberculous mycobacteria (NTM) disease represents a significant threat to patients with cystic fibrosis (CF), an estimated annual prevalence of 12%. Prior studies reported increasing NTM in the general population, though similar trends persons CF have not been assessed.In this study we aimed identify prevalence, geographic patterns, temporal trends, and risk factors for positivity by mycobacterial species among throughout United States.Using annualized Patient Registry (CFFPR)...
State-specific case numbers and costs are critical for quantifying the burden of pulmonary nontuberculous mycobacterial disease in United States.To estimate project national state annual cases associated direct medical costs.Available cost estimates encounters were applied to prevalence derived from Medicare beneficiary data (2003-2007). Prevalence was adjusted International Classification Diseases, 9th Revision, undercoding inclusion persons younger than 65 years age. U.S. Census Bureau...
Persons with cystic fibrosis (CF) are at greater risk of nontuberculous mycobacterial (NTM) infections than the general population. However, among patients CF, geographic variation in prevalence is poorly understood.To describe and screening practices NTM U.S. CF.CF Patient Registry data from 2010-2011 were obtained to estimate CF 12 years age or older by state. Climatic also predictors infection analyzed using regression analysis. Geographic clustering culture rates state assessed.Among...
Rationale: The 2007 American Thoracic Society (ATS) and Infectious Diseases of America (IDSA) recommend that patients with pulmonary nontuberculous mycobacterial (PNTM) disease caused by Mycobacterium avium complex (MAC) or M. abscessus be treated a macrolide-based multidrug antibiotic regimen until sputum culture negative for 1 year. After 6 years, the degree adherence to recommended guidelines among physicians remains unknown.Objective: To describe treatment practices treating PNTM in...
Persons with cystic fibrosis (CF) are at high risk of nontuberculous mycobacterial (NTM) infection, treatment requiring prolonged multidrug regimens that include macrolides. Although macrolides, specifically azithromycin, used in the management patients CF chronic Pseudomonas, macrolide-resistant NTM infections growing concern.To evaluate relationship between macrolide use and infection among included 2011 Patient Registry (CFPR).We performed a nested case-control study: incident cases were...
Severe Plasmodium falciparum malaria is a major cause of death in children. The contribution the parasite burden to pathogenesis severe has been controversial.
Invasive candidiasis is a major nosocomial fungal disease in the United States associated with high rates of illness and death. We analyzed inpatient hospitalization records from Healthcare Cost Utilization Project to estimate incidence invasive candidiasis-associated hospitalizations States. extracted data for 33 states 2002-2012 by using codes International Classification Diseases, 9th Revision, Clinical Modification, candidiasis; we excluded neonatal cases. The overall age-adjusted...
Nontuberculous mycobacteria are an important cause of morbidity in the United States, although patient outcomes vary greatly by species. Currently, nationally representative data on distribution mycobacterial species from clinical isolates limited.Using a national hospitalization database capturing microbiologic for nearly 6 million encounters, we describe geographic of, and demographic features associated with, States.Linked Premier Healthcare Database were extracted all encounters 2009 to...
Previous studies found Hawaiians and Asian-Americans/Pacific Islanders to be independently at increased risk for nontuberculous mycobacterial pulmonary disease (NTMPD) tuberculosis (TB). To better understand NTM infection TB patterns in Hawaii, USA, we evaluated data on a cohort of patients Hawaii 2005-2013. Period prevalence NTMPD was highest among Japanese, Chinese, Vietnamese (>300/100,000 persons) lowest Native Other Pacific (50/100,000). Japanese were twice as likely all other...