A5052151394- Influenza Virus Research Studies
- Respiratory viral infections research
- Traumatic Brain Injury and Neurovascular Disturbances
- Viral Infections and Vectors
- Respiratory Support and Mechanisms
- Fire effects on ecosystems
- Animal Disease Management and Epidemiology
- Tracheal and airway disorders
- Immune Response and Inflammation
- Cerebrospinal fluid and hydrocephalus
- Airway Management and Intubation Techniques
- Myofascial pain diagnosis and treatment
- Disaster Response and Management
- Cardiac Arrest and Resuscitation
- Virology and Viral Diseases
- Musculoskeletal pain and rehabilitation
- Traumatic Brain Injury Research
- Vibrio bacteria research studies
- Bacterial Infections and Vaccines
- Neonatal and fetal brain pathology
- Spine and Intervertebral Disc Pathology
- interferon and immune responses
- Viral Infections and Outbreaks Research
National Institute of Allergy and Infectious Diseases
2014-2024
National Institutes of Health
2020-2024
Augusta University
2020-2024
Children's Healthcare of Atlanta
2019-2020
Emory University
2011-2019
Tulane University
2012
The University of Texas Medical Branch at Galveston
2012
Influenza A viruses (IAVs) present major public health threats from annual seasonal epidemics and pandemics adapted to a variety of animals including poultry, pigs, horses. Vaccines that broadly protect against all such IAVs, so-called “universal” influenza vaccines, do not currently exist but are urgently needed. Here, we demonstrated an inactivated, multivalent whole-virus vaccine, delivered intramuscularly or intranasally, was protective challenges with multiple IAV hemagglutinin...
Objectives: The purpose of this study was to determine correlation and temporal association between automated pupillary measurements intracranial pressure in pediatric patients with brain injury or encephalopathy requiring monitoring. We hypothesized that abnormal would precede increases pressure. Design: A prospective cohort performed. Automated pupillometry were obtained at the same frequency as patients’ neurologic assessments concurrent measurement pressure, for up 72 hours. Pupillary...
Abstract Despite the importance of immunity against neuraminidase (NA), NA content and immunogenicity are neglected in current influenza vaccines. To address this, a recombinant N1/N2 vaccine (NAV) was developed. Stability assays were used to determine optimal temperature buffer conditions for storage. The effect divalent cation-related enhancement stability activity on N1 N2 efficacy viral challenge assessed. Differences between did not translate into differences or efficacy. NAV-vaccinated...
Seoul virus, an Old World hantavirus, is maintained in brown rats and causes a mild form of hemorrhagic fever with renal syndrome (HFRS) humans. We captured rodents New Orleans, Louisiana tested them for the presence hantaviruses by reverse transcription polymerase chain reaction (RT-PCR) sequencing, cell culture, electron microscopy; 6 (3.4%) 178 captured—all rats—were positive virus variant previously coined Tchoupitoulas which was noted Orleans 1980s. The finding over 25 years since its...
OBJECTIVES: Extremes of patient body mass index are associated with difficult intubation and increased morbidity in adults. We aimed to determine the association between being underweight or obese adverse airway outcomes, including tracheal (TI)-associated events (TIAEs) and/or severe peri-intubation hypoxemia (pulse oximetry oxygen saturation < 80%) critically ill children. DESIGN/SETTING: Retrospective cohort using National Emergency Airway for Children registry dataset 2013–2020....
Abstract Background Nasal tracheal intubation (TI) represents a minority of all TI in the pediatric intensive care unit (PICU). The risks and benefits nasal are not well quantified. As such, safety descriptive data regarding this practice warranted. Methods We evaluated association between route outcomes prospectively collected quality improvement database (National Emergency Airway Registry for Children: NEAR4KIDS) from 2013 to 2020. primary outcome was severe desaturation (SpO 2 > 20%...
Zoonotic influenza A virus (IAV) infections pose a substantial threat to global health. The RNA-dependent RNA polymerase (RdRp) comprises the PB2, PB1, and PA proteins. Of last four pandemic IAVs, three featured avian-origin PB1 genes. Prior research linked these avian genes increased viral fitness when reassorted with human IAV This study evaluated chimeric RdRps from 1918, 1957, 1968 IAVs in low pathogenic (LPAI) background assess activity pathogenicity. Substituting reduced activity,...
Introduction: Primary amebic meningoencephalitis (PAM) caused by Naegleria fowleri is rare, rapidly progressive, and often fatal. The Centers for Disease Control has documented 154 US cases with only 4 survivors; thus timely diagnosis treatment remain a challenge. Description: A previously healthy 17-year-old female, who swam at lake, was admitted to PICU 5 days of fever, headache, 24 hours progressive altered mental status. In the pediatric emergency department, patient profoundly...
Hantaviruses are lipid-enveloped, tri-segmented RNA viruses belonging to the family Bunyaviridae. divided taxonomically into Old World and New groups that typically cause hemorrhagic fever with renal syndrome hantavirus pulmonary syndrome, respectively. Each is specific a rodent reservoir host. In 1983, isolation of an similar Seoul virus (Tchoupitoulas virus) occurred from rats caught in Orleans, Louisiana, but date, this has not been associated human disease. Since time, no surveillance...
Abstract Influenza A viruses (IAVs) present major public health threats from annual seasonal epidemics, pandemics caused by novel virus subtypes, and adapted to a variety of animals including poultry, pigs horses. Vaccines that broadly protect against all such IAVs, so-called “universal” influenza vaccines, do not currently exist, but are urgently needed. This study demonstrates an inactivated, multivalent whole vaccine, delivered intramuscularly or intranasally, is protective challenges...