Fabrizio Chiusolo
A5017792535- Respiratory Support and Mechanisms
- Clinical Nutrition and Gastroenterology
- Mechanical Circulatory Support Devices
- Neonatal Respiratory Health Research
- Sepsis Diagnosis and Treatment
- Airway Management and Intubation Techniques
- Tracheal and airway disorders
- Organ Transplantation Techniques and Outcomes
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cardiac Arrest and Resuscitation
- Liver Disease and Transplantation
- Intensive Care Unit Cognitive Disorders
- Hemodynamic Monitoring and Therapy
- Electrolyte and hormonal disorders
- Family and Patient Care in Intensive Care Units
- Childhood Cancer Survivors' Quality of Life
- Congenital Diaphragmatic Hernia Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Emergency and Acute Care Studies
- Blood transfusion and management
- Renal function and acid-base balance
- Organ Donation and Transplantation
- Anesthesia and Neurotoxicity Research
- Central Venous Catheters and Hemodialysis
- Intestinal Malrotation and Obstruction Disorders
Bambino Gesù Children's Hospital
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2016-2025
Università Cattolica del Sacro Cuore
2001
The purpose of our study was to describe children with life-threatening bleeding.We conducted a prospective observational bleeding events.Twenty-four childrens hospitals in the United States, Canada, and Italy participated.Children 0-17 years old who received greater than 40 mL/kg total blood products over 6 hours or were transfused under massive transfusion protocol included.Children compared according etiology: trauma, operative, medical.Patient characteristics, therapies administered,...
<h3>Importance</h3> The clinical consequences of red blood cell storage age for critically ill pediatric patients have not been examined in a large, randomized trial. <h3>Objective</h3> To determine if the transfusion fresh cells (stored ≤7 days) reduced new or progressive multiple organ dysfunction syndrome compared with use standard-issue children. <h3>Design, Setting, and Participants</h3> Age Transfused Blood Critically-Ill Children trial was an international, multicenter, blinded,...
Abstract Background Early mobilization of adults receiving intensive care improves health outcomes, yet little is known about practices in paediatric units (PICUs). We aimed to determine the prevalence and factors associated with physical rehabilitation PICUs across Europe. Methods A 2-day, cross-sectional, multicentre point study was conducted May November 2018. The primary outcome therapy (PT)- or occupational (OT)-provided mobility. Clinical data on patient mobility, potential mobility...
Abstract Background Mechanical power is a composite variable for energy transmitted to the respiratory system over time that may better capture risk ventilator-induced lung injury than individual ventilator management components. We sought evaluate if mechanical ventilation with high associated fewer ventilator-free days (VFD) in children pediatric acute distress syndrome (PARDS). Methods Retrospective analysis of prospective observational international cohort study. Results There were 306...
In pediatric liver recipients perioperative factors may affect respiratory and cardiac function, prolong mechanical ventilation during post-operative period. The use of NAVA can improve the interaction between patient ventilator from both a perspective. objective this study is to evaluate synchronization ventilator, as well application neurally adjusted ventilatory assist (NAVA) pressure support (PSV) in transplant recipients. This single-center, prospective, randomized, physiological...
Abstract Aim To explore ventilator settings, ventilation variables and parameters in critically ill pediatric patients across European Centers. Methods International, multicenter, prospective observational study, collecting data for 7 days from aged ≤ 12 years, requiring ventilatory support ≥ h. Primary endpoint was a set of key including tidal volume (V T ), respiratory rate (RR), peak mean airway pressure (Ppeak Pmean), positive end–expiratory (PEEP), the fraction inspired oxygen (FiO 2 )....
OBJECTIVES: To characterize the epidemiology and management of massive bleeding events in children with cancer and/or hematopoietic cell transplant (HCT). DESIGN: Multicenter, retrospective cohort study. SETTING: Nineteen pediatric hospitals Europe United States. SUBJECTS: Children ages 0–21 years old malignancy HCT admitted from January 1, 2017, to December 31, 2021. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Demographics, oncologic history, laboratory values, interventions, PICU...
Abstract Background Internationally, there is an increasing trend in using Rapid Response Systems (RRS) to stabilize in‐patient deterioration. Despite a growing evidence base, remains limited understanding of the processes place aid early recognition and response deteriorating children hospitals across Europe. Aim/s To describe for deterioration European hospitals. Study Design A cross‐sectional opportunistic multi‐centre study, with paediatric in‐patients, descriptive self‐reported,...
Vascular complications are a major cause of patient and graft loss after LTs. The aim this study was to evaluate the effect multimodal perioperative strategy aimed at reducing incidence vascular complications. A total 126 first isolated LTs-performed between November 2008 December 2015-were retrospectively analyzed. minimum follow-up period 24 months analyzable for 124/126 patients (98.4%). aggressive preemptive consisted identifying immediately managing any problem abnormality in flow,...
Background: The number of children requiring prolonged mechanical ventilation (PMV) has increased with the advancement medical care. This study aims to investigate prevalence and background PMV in pediatric intensive care units (PICUs), as well management healthcare burden.Methods: An international epidemiological was conducted a cross-sectional prospective cohort design. Screenings were performed every three months for years, from June 2019 December 2022. defined including invasive...
ABSTRACT Background Italy presently does not have a pediatric organ donation program after cardiocirculatory determination of death (pDCDD). Before implementing pDCDD program, many centers globally conducted studies on the attitudes intensive care unit (PICU) staff. This research aims to minimize potential adverse reactions and evaluate acceptance novel practice. Methods We an electronic anonymous survey toward among healthcare professionals (HCPs) working at eight Italian PICUs. The had...
Objectives: We hypothesized that antibiotic use in PICUs is based on criteria not always supported by evidence. aimed to describe determinants of empiric eight different countries. Design: Cross-sectional survey. Setting: Canada, the United States, France, Italy, Saudi Arabia, Japan, Thailand, and Brazil. Subjects: Pediatric intensivists. Interventions: None. Measurements Main Results: used literature review focus groups develop survey its clinical scenarios (pneumonia, septic shock,...
Sarcopenia is a clinical condition characterized by reduction in muscle mass, which typically affects adult patients; however, it has recently been recognized pediatric literature. Few studies children with chronic liver disease (CLD) undergoing transplantation (LT) have investigated the role of sarcopenia, controversial results. The aim our study was to assess prevalence and impact sarcopenia among CLD who are candidates for LT. We conducted retrospective, single-center at Bambino Gesù...
Objective: To describe the management of anemia at PICU discharge by pediatric intensivists. Design: Self-administered, online, scenario-based survey. Setting: PICUs in Australia/New Zealand, Europe, and North America. Subjects: Pediatric Interventions: None. Measurements Main Results: Respondents were asked to report their decisions regarding RBC transfusions, iron, erythropoietin prescription children ready be discharged from PICU, who had been admitted for hemorrhagic shock, cardiac...
Abstract Background Increasing procedures in day-case surgery can mitigate the costs of health service, without reducing safety and quality standards. The Ospedale Pediatrico Bambino Gesù has adopted an educational program for healthcare personnel patients’ families to increase number performed level safety. unplanned admission rate after be a benchmark pediatric surgery, literature, there are no Italian data. Methods We made retrospective analysis hospital database focused on children...
OBJECTIVES: Extremes of patient body mass index are associated with difficult intubation and increased morbidity in adults. We aimed to determine the association between being underweight or obese adverse airway outcomes, including tracheal (TI)-associated events (TIAEs) and/or severe peri-intubation hypoxemia (pulse oximetry oxygen saturation < 80%) critically ill children. DESIGN/SETTING: Retrospective cohort using National Emergency Airway for Children registry dataset 2013–2020....
Abstract ARF after pediatric liver transplantation accounts for high rate of morbidity and mortality associated with this procedure. The role CPAP in postoperative period is still unknown. aim the study was to describe current practice risk factors application helmet . In retrospective observational cohort study, 119 recipients were divided into two groups based on indication extubation. Perioperative variables studied, determinants analyzed a multivariate logistic model. Sixty patients...