A5003790077- Blood transfusion and management
- Blood groups and transfusion
- Hemoglobinopathies and Related Disorders
- Neonatal Health and Biochemistry
- Blood donation and transfusion practices
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Neonatal Respiratory Health Research
- Erythrocyte Function and Pathophysiology
- Platelet Disorders and Treatments
- Trauma and Emergency Care Studies
- Infant Nutrition and Health
- Blood disorders and treatments
- Hematopoietic Stem Cell Transplantation
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Organ Donation and Transplantation
- Hemophilia Treatment and Research
- Cytomegalovirus and herpesvirus research
- COVID-19 Clinical Research Studies
- Cardiac Arrest and Resuscitation
- Sepsis Diagnosis and Treatment
- Neonatal and fetal brain pathology
- SARS-CoV-2 and COVID-19 Research
- Parvovirus B19 Infection Studies
- Congenital Diaphragmatic Hernia Studies
- Chronic Myeloid Leukemia Treatments
Johns Hopkins University
2022-2025
Johns Hopkins All Children's Hospital
2022-2025
Johns Hopkins Medicine
2022-2025
Sidney Kimmel Comprehensive Cancer Center
2025
Seattle University
2016-2024
Emory University
2015-2024
Children's Healthcare of Atlanta
2014-2023
Aflac (United States)
2008-2023
Center for Cancer and Blood Disorders
2009-2023
Sidney Kimmel Cancer Center
2022
We conducted a trial of prophylactic platelet transfusions to evaluate the effect dose on bleeding in patients with hypoproliferative thrombocytopenia.
Some observational studies have reported that transfusion of red-cell units been stored for more than 2 to 3 weeks is associated with serious, even fatal, adverse events. Patients undergoing cardiac surgery may be especially vulnerable the effects transfusion.We conducted a randomized trial at multiple sites from 2010 2014. Participants 12 years age or older who were complex and likely undergo red cells randomly assigned receive leukocyte-reduced 10 days less (shorter-term storage group) 21...
<h3>Importance</h3> Data regarding the contribution of red blood cell (RBC) transfusion and anemia to necrotizing enterocolitis (NEC) are conflicting. These associations have not been prospectively evaluated, accounting for repeated, time-varying exposures. <h3>Objective</h3> To determine relationship between RBC transfusion, severe anemia, NEC. <h3>Design, Setting, Participants</h3> In a secondary, prospective, multicenter observational cohort study from January 2010 February 2014, very...
Objectives: To date, there are no published guidelines to direct RBC transfusion decision-making specifically for critically ill children. We present the recommendations from Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Design: Consensus conference series of multidisciplinary, international experts in management Setting: Not applicable. Intervention: None. Subjects: Children with, or children at risk for, critical illness who receive receiving a transfusion. Methods:...
Postnatal cytomegalovirus (CMV) infection can cause serious morbidity and mortality in very low-birth-weight (VLBW) infants. The primary sources of postnatal CMV this population are breast milk blood transfusion. current risks attributable to these vectors, as well the efficacy approaches prevent transmission, poorly characterized. To estimate risk transmission from 2 sources: (1) transfusion CMV-seronegative leukoreduced (2) maternal milk. A prospective, multicenter birth-cohort study was...
In the absence of scientific evidence, current neonatal platelet transfusion practices are based on physicians' preferences, expert advice, or consensus-driven recommendations. We hypothesized that there would be significant diversity in triggers, product selection, and dosing among neonatologists United States Canada.A Web-based survey was distributed to all members American Academy Pediatrics Perinatal Section physicians listed 2005 Canadian Neonatology Directory.The overall response rate...
BACKGROUND: Massive transfusion protocols (MTPs) with fixed ratios of blood products may improve outcomes in coagulopathic adult trauma patients. However, there is a paucity data on support for pediatric patients, whose mechanisms injury differ from those seen adults. We hypothesized that an MTP would children, through balanced product resuscitation. STUDY DESIGN AND METHODS: A MTP, ratio red cells (RBCs) : fresh‐frozen plasma (FFP) platelets cryoprecipitate quantities based the patient's...
BACKGROUND Although red blood cell (RBC) transfusion represents an integral component of sickle disease (SCD) care, support for some patients can result in alloimmunization to RBC antigens. Alloimmunized with SCD appear experience worse survival compared nonalloimmunized patients. While this difference mortality may part be due underlying immunologic differences related severity, it also reflect direct clinical consequences alloimmunization. have increased risk serious hemolytic reactions...
Key Points The RBD of SARS-CoV-2 shares sequence similarity with an ancient lectin family known to bind blood group antigens. binds the A expressed on respiratory epithelial cells, directly linking and SARS-CoV-2.
Thrombocytopenia and intraventricular hemorrhage (IVH) are common among very-low-birth-weight (VLBW) infants. Survey results suggest that US neonatologists frequently administer platelet transfusions to VLBW infants with mild moderate thrombocytopenia.To characterize transfusion practices in neonatal intensive care units (NICUs), determine whether severity of illness influences decisions, examine the association between count (PCT) risk for IVH first 7 days life.This multicenter,...
<h3>Importance</h3> The clinical consequences of red blood cell storage age for critically ill pediatric patients have not been examined in a large, randomized trial. <h3>Objective</h3> To determine if the transfusion fresh cells (stored ≤7 days) reduced new or progressive multiple organ dysfunction syndrome compared with use standard-issue children. <h3>Design, Setting, and Participants</h3> Age Transfused Blood Critically-Ill Children trial was an international, multicenter, blinded,...
The purpose of our study was to describe children with life-threatening bleeding.We conducted a prospective observational bleeding events.Twenty-four childrens hospitals in the United States, Canada, and Italy participated.Children 0-17 years old who received greater than 40 mL/kg total blood products over 6 hours or were transfused under massive transfusion protocol included.Children compared according etiology: trauma, operative, medical.Patient characteristics, therapies administered,...
Transfusion of group O single-donor apheresis PLTs (SDP) to A recipients has resulted in intravascular hemolysis and mortality. Owing low availability type-specific SDPs, transfusion services sometimes issue ABO-mismatched PLTs. After observing two cases acute following infusion SDPs patients, where both recipient eluates revealed anti-A specificity, a prospective study determine the prevalence "high-titer" anti-A/A,B was commenced. One hundred SDP samples were tested. Titers at least 64...
BACKGROUND: Thrombocytopenia affects 20% to 35% of patients admitted neonatal intensive care units (NICUs). Platelet (PLT) transfusions are usually administered neonates with thrombocytopenia at higher thresholds than those used for older children or adults, although there is a paucity evidence guide these decisions. STUDY DESIGN AND METHODS: In this study, we Web‐based survey investigate the PLT transfusion in Level 1 NICUs (equivalent 3 US) three European countries (Austria, Germany, and...