Oliver Karam
A5037388698- Blood transfusion and management
- Sepsis Diagnosis and Treatment
- Mechanical Circulatory Support Devices
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cardiac Arrest and Resuscitation
- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Hemoglobinopathies and Related Disorders
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Neonatal Health and Biochemistry
- Family and Patient Care in Intensive Care Units
- Intensive Care Unit Cognitive Disorders
- Blood donation and transfusion practices
- Infant Development and Preterm Care
- Renal function and acid-base balance
- Nosocomial Infections in ICU
- Hemodynamic Monitoring and Therapy
- Heart Failure Treatment and Management
- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Trauma and Emergency Care Studies
- Abdominal Trauma and Injuries
- Transplantation: Methods and Outcomes
Yale University
2022-2025
Children's Hospital of Richmond at VCU
2016-2024
Virginia Commonwealth University
2018-2023
Shaikh Khalifa Medical City
2023
King Faisal University
2023
King Saud bin Abdulaziz University for Health Sciences
2023
International Medical Research (Germany)
2023
University of Alabama at Birmingham
2022
Society of Critical Care Medicine
2022
Boston Children's Hospital
2021
Objectives: To develop evidence-based recommendations for clinicians caring children (including infants, school-aged children, and adolescents) with septic shock other sepsis-associated organ dysfunction. Design: A panel of 49 international experts, representing 12 organizations, as well three methodologists public members was convened. Panel assembled at key meetings (for those attending the conference), a stand-alone meeting held all in November 2018. formal conflict-of-interest policy...
Objectives: To date, there are no published guidelines to direct RBC transfusion decision-making specifically for critically ill children. We present the recommendations from Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Design: Consensus conference series of multidisciplinary, international experts in management Setting: Not applicable. Intervention: None. Subjects: Children with, or children at risk for, critical illness who receive receiving a transfusion. Methods:...
The objective was to determine if there is an association between red blood cell (RBC) storage time and development of new or progressive multiple organ dysfunction syndrome (MODS) in critically ill children.This analytic cohort analysis patients enrolled a randomized controlled trial, TRIPICU (Transfusion Requirements Pediatric Intensive Care Units; ISRCTN37246456), which stable children were randomly assigned restrictive liberal strategy. Transfused analyzed using three different sliding...
Abstract Introduction Transfusion is a common treatment in pediatric intensive care units (PICUs). Studies adults suggest that prolonged storage of red blood cell associated with worse clinical outcome. No prospective study has been conducted children. Our objectives were to assess the impact length on outcome critically ill Methods Prospective, observational 30 North American centers, consecutive patients aged <18 years stay ≥ 48 hours PICU. The primary measure was incidence multiple...
Little is known about platelet transfusions in pediatric critical illness. We sought to describe the epidemiology, indications, and outcomes of among critically ill children.Prospective cohort study.Multicenter (82 PICUs), international (16 countries) from September 2016 April 2017.Children ages 3 days 16 years prescribed a transfusion ICU during screening days.None.Over 6 weeks, 16,934 patients were eligible, 559 received at least one (prevalence, 3.3%). The indications for included...
Plasma transfusions are frequently prescribed for critically ill children, although their indications lack a strong evidence base. largely driven by physician conceptions of need, and these poorly documented in pediatric intensive care patients.To identify patient characteristics to characterize leading plasma assess the effect on coagulation tests.Point-prevalence study 101 units 21 countries, 6 predefined weeks. All children admitted participating unit were included if they received at...
In 2001, the Surviving Sepsis Campaign (SSC) began to develop evidence-based guidelines and recommendations for resuscitation management of patients with sepsis. With 2016 edition, Society Critical Care Medicine European Intensive recommended a separate task force be dedicated guideline formulation children. The objective "Surviving International Guidelines Management Septic Shock Sepsis-associated Organ Dysfunction in Children" is provide guidance care infants, children, adolescents septic...
Objectives: In children with severe sepsis or septic shock, the optimal red blood cell transfusion threshold is unknown. We analyzed subgroup of patients and requirements in a pediatric intensive care unit study to determine impact restrictive vs. liberal strategy on clinical outcome. Design: Subgroup analysis prospective, multicenter, randomized, controlled trial. Setting: Multicenter critical units. Patients: Stabilized critically ill (mean systemic arterial pressure >2 sd below normal...
Plasma transfusions are commonly used in adult and paediatric intensive care units. Recent data suggest an association between plasma worse clinical outcome trauma patients. To date, no prospective study has addressed this issue. Our objective was to prospectively analyse the of critically ill children.Prospective, observational single centre that includes all consecutive admissions a tertiary level multidisciplinary critical unit over 1-year period. The primary measure incidence after...
The relationship between length of storage red blood cell (RBC) units and biochemical changes has been well studied, but little is known about the progression cellular immunomodulative properties in recipients. This study aims to quantify vitro T-cell activation cytokine release by white cells, after incubation with supernatants from leukoreduced RBCs.Whole cultures were incubated supernatant five RBC stored for 1, 6, 10, 15, 24, 42 days. Supernatant-induced was evaluated quantifying CD25...
To document the prevalence of asynchrony events during noninvasive ventilation in pressure support infants and children to compare results with neurally adjusted ventilatory assist.Prospective randomized cross-over study undergoing ventilation.The was performed a PICU.From 4 weeks 5 years.Two consecutive periods (pressure assist) were applied random order. During (PS), three levels expiratory trigger (ETS) setting compared: initial ETS (PSinit), value decreased increased by 15%. Of sessions,...
Objectives: To document and compare the prevalence of asynchrony events during invasive-assisted mechanical ventilation in pressure support mode neurally adjusted ventilatory assist children. Design: Prospective, randomized, crossover study. Setting: Pediatric Neonatal Intensive Care Unit, University Hospital Geneva, Switzerland. Patients: Intubated mechanically ventilated children, between 4 weeks 5 years old. Interventions: Two consecutive periods (pressure assist) were applied random...
Objective: Although bleeding frequently occurs in critical illness, no published definition to date describes the severity of accurately critically ill children. We sought develop diagnostic criteria for Design: Delphi consensus process multidisciplinary experts bleeding/hemostasis children, followed by prospective cohort study test internal validity. Setting: PICU. Patients: Children at risk PICUs. Interventions: None. Measurements and Main Results: Twenty-four physicians worldwide (10 on a...
Prior criteria for organ dysfunction in critically ill children were based mainly on expert opinion. We convened the Pediatric Organ Dysfunction Information Update Mandate (PODIUM) panel to summarize data characterizing single and multiple derive contemporary pediatric dysfunction. The was composed of 88 members representing 47 institutions 7 countries. conducted systematic reviews literature evidence-based neurologic, cardiovascular, respiratory, gastrointestinal, acute liver, renal,...