A5035626239- Neonatal Respiratory Health Research
- Infant Development and Preterm Care
- Neuroscience of respiration and sleep
- Pediatric Pain Management Techniques
- Neonatal Health and Biochemistry
- Congenital Diaphragmatic Hernia Studies
- Respiratory Support and Mechanisms
- Neonatal and fetal brain pathology
- Health, Medicine and Society
- Methemoglobinemia and Tumor Lysis Syndrome
- Neonatal skin health care
- Airway Management and Intubation Techniques
- Thermal Regulation in Medicine
- Infant Nutrition and Health
- Heme Oxygenase-1 and Carbon Monoxide
- Sleep and Wakefulness Research
- Clinical Nutrition and Gastroenterology
- Urological Disorders and Treatments
- Effects and risks of endocrine disrupting chemicals
- Anesthesia and Neurotoxicity Research
- Congenital Heart Disease Studies
- Family and Patient Care in Intensive Care Units
- Pulmonary Hypertension Research and Treatments
- Child and Adolescent Health
- Homicide, Infanticide, and Child Abuse
Périnatalité & Risques Toxiques
2016-2025
Centre Hospitalier Universitaire Amiens-Picardie
2016-2025
Université de Picardie Jules Verne
2016-2025
Institut national de l'environnement industriel et des risques
2010-2023
Lyon College
2023
Versus Arthritis
2022
Weatherford College
2022
Université Lille Nord de France
2017
Université Paris Cité
2016
Sorbonne Université
2016
Although inhaled NO (iNO) therapy is often effective in treating infants with persistent pulmonary hypertension of the newborn (PPHN), up to 40% patients fail respond, which may be partly due abnormal expression and function soluble guanylate cyclase (sGC). To determine whether altered sGC or activity oxidized contributes high vascular resistance (PVR) poor responsiveness, we studied effects cinaciguat (BAY 58-2667), an activator, on artery smooth muscle cells (PASMC) from normal fetal sheep...
Pregnant women are exposed to various chemical products at home and work. Some of these contain endocrine-disrupting chemicals (EDCs) such as cosmetics, pesticides, industrial chemicals, heavy metals, plastics or medications that could alter sexual differentiation increase the risk hypospadias. We evaluated maternal occupational household exposures constitute factors for From 2011 2014, we enrolled 57 full-term newborns with hypospadias three randomly selected controls per case (162 control...
Whether inhaled nitric oxide (iNO) prevents the development of bronchopulmonary dysplasia (BPD) in premature infants is controversial. In adult rats, bleomycin (Bleo) induces lung fibrosis and pulmonary hypertension, but effects Bleo on developing iNO treatment Bleo-induced neonatal injury are uncertain. Therefore, we sought to determine whether early prolonged therapy attenuates changes vascular alveolar structure a model BPD induced by rats. Sprague-Dawley rat pups were treated with (1...
To document the prevalence of asynchrony events during noninvasive ventilation in pressure support infants and children to compare results with neurally adjusted ventilatory assist.Prospective randomized cross-over study undergoing ventilation.The was performed a PICU.From 4 weeks 5 years.Two consecutive periods (pressure assist) were applied random order. During (PS), three levels expiratory trigger (ETS) setting compared: initial ETS (PSinit), value decreased increased by 15%. Of sessions,...
Objectives: To document and compare the prevalence of asynchrony events during invasive-assisted mechanical ventilation in pressure support mode neurally adjusted ventilatory assist children. Design: Prospective, randomized, crossover study. Setting: Pediatric Neonatal Intensive Care Unit, University Hospital Geneva, Switzerland. Patients: Intubated mechanically ventilated children, between 4 weeks 5 years old. Interventions: Two consecutive periods (pressure assist) were applied random...
Abstract Aim: To determine the effects of noradrenaline in full‐term newborns with refractory septic shock. Methods: Newborns >35 weeks' gestation persistent shock, despite adequate fluid resuscitation and high dose dopamine/dobutamine were eligible. In this prospective observational study, we recorded respiratory hemodynamic parameters prior to 3 h after starting infusion. Results: Twenty‐two included (gestational age [GA] 39 ± 1.7 weeks, birth weight (BW) 3110 780 g). Before...
Various analgesic strategies are used before tracheal intubation of preterm newborns in the delivery room, due to lack a standard protocol and difficult venous access. This study evaluated feasibility efficacy short catheter insertion immediate ketamine analgesia for at birth room.Prospective observational pilot study, with atropine paediatrician's discretion. Pain score, heart rate, SpO2 nadirs, procedure duration neonatal intensive care unit morbidity were recorded.Fifty-seven consecutive...
Propofol or a combination of synthetic opioid and muscle relaxant are both recommended for premedication before neonatal intubation but have yet to be compared.To compare prolonged desaturation during nasotracheal after with atropine-propofol vs atropine-atracurium-sufentanil treatment.Multicenter, double-blind, randomized clinical trial (2012-2016) in 6 NICUs France that included 173 neonates requiring nonemergency intubation. The study was interrupted due expired kits lack...
Impaired nitric oxide-cGMP signaling contributes to severe pulmonary hypertension after birth, which may in part be due decreased soluble guanylate cyclase (sGC) activity. Cinaciguat (BAY 58-2667) is a novel sGC activator that causes vasodilation, even the presence of oxidized heme or heme-free sGC, but its hemodynamic effects have not been studied perinatal lung. We performed surgery on eight fetal (126 ± 2 days gestation) lambs (full term = 147 days) and placed catheters main artery,...
To describe and assess routine procedures practices for incubator temperature humidity management in France 2009.A questionnaire was sent to all the 186 neonatal care units France.The return rate 86%. Seventy-five per cent of preferred skin servo-control air control practice. Air mainly used infants with a gestational age more than 28 weeks aged over 7 days life. In general, thermal decisions did not depend on infant's but were based protocol applied specifically by each unit. All humidified...