A5052877432- Blood groups and transfusion
- Blood transfusion and management
- Blood donation and transfusion practices
- Hemoglobinopathies and Related Disorders
- Erythrocyte Function and Pathophysiology
- Platelet Disorders and Treatments
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Complement system in diseases
- Hematopoietic Stem Cell Transplantation
- Blood disorders and treatments
- Neonatal Health and Biochemistry
- Cardiac Arrest and Resuscitation
- Renal Diseases and Glomerulopathies
- Organ Transplantation Techniques and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Prenatal Screening and Diagnostics
- Trauma and Emergency Care Studies
- Hemophilia Treatment and Research
- Organ Donation and Transplantation
- Hepatitis B Virus Studies
- Atrial Fibrillation Management and Outcomes
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Liver Disease and Transplantation
- Immune Cell Function and Interaction
Medical College of Wisconsin
2012-2021
Versiti Blood Center of Wisconsin
2011-2021
Medical Diagnostic Laboratories (United States)
2017-2021
Children's National
2021
University of North Carolina System
2021
University of North Carolina at Chapel Hill
2021
University of Wisconsin–Madison
2010-2014
Georgetown University
2012-2014
Pennsylvania State University
2014
New York Blood Center
2014
BACKGROUND: Antibodies to human leukocyte antigens (HLA) in donated blood have been implicated as a cause of transfusion-related acute lung injury (TRALI). A potential measure reduce the risk TRALI includes screening plateletpheresis donors for HLA antibodies. The prevalence antibodies and their relationship previous transfusion or pregnancy was determined. STUDY DESIGN AND METHODS: total 8171 volunteer were prospectively recruited by six US centers from December 2006 May 2007. Donors...
PATIENTS with the acquired immunodeficiency syndrome (AIDS) include male homosexuals, intravenous drug abusers, and Haitian immigrants to United States.1 2 3 Approximately half patients have contracted Pneumocystis carinii pneumonia, a third Kaposi's sarcoma, 10 per cent concurrent sarcoma P. pneumonia. The mortality rate approaches 40 cent. Persistent generalized lymphadcnopathy diffuse undifferentiated non-Hodgkin's lymphoma also been reported in homosexual males are considered part of...
We describe a four-year experience with bone marrow transplantation involving closely HLA-matched unrelated donors and 55 consecutive patients hematologic disease who were seven months to 48.6 years old (median, 18 years). An intensive pretransplantation conditioning regimen graft-versus-host (GVHD) prophylaxis CD3-directed T-cell depletion cyclosporine employed.
Objective. Alloimmunization in patients with sickle cell disease (SCD) has a reported incidence of 5% to 36%. One complication alloimmunization is delayed hemolytic transfusion reaction/hyperhemolysis (DHTR/H) syndrome, which 11%. In SCD, clinical findings DHTR/H syndrome occur approximately 1 week after the red blood (RBC) and include onset increased hemolysis associated pain profound anemia. The hemoglobin (Hb) often drops below pretransfusion levels. many adult cases, direct antiglobulin...
BACKGROUND Prevalence estimates of the serious hazards transfusion vary widely. We hypothesized that current reporting infrastructure in United States fails to capture many reactions and undertook a multicenter study using active surveillance, data review, adjudication test this hypothesis. STUDY DESIGN AND METHODS A retrospective record review was completed for random sample 17% all inpatient episodes over 6 months at four academic tertiary care hospitals, with an episode defined as blood...
Drug-induced immune hemolytic anemia (DIIHA) is an uncommon finding characterized by a sudden decrease in hemoglobin after treatment with the putative drug. The full range of drugs causing DIIHA and initial serologic presentation are not fully appreciated. This work identifies additional associated offers insights about diagnosis.A 20-year retrospective review testing one laboratory was performed. Patient sex, age, medication history, direct antiglobulin test (DAT) indirect test, method...
BACKGROUND Blood transfusion is one of the most common medical procedures during hospitalization in United States. To understand benefits while mitigating potential risks, a multicenter database containing detailed information on incidence and recipient outcomes would facilitate research. STUDY DESIGN AND METHODS The Recipient Epidemiology Donor Evaluation Study‐III (REDS‐III) program has developed comprehensive utilizing data from hospital electronic health records at 12 participating...
BACKGROUND The Pragmatic, Randomized Optimal Platelets and Plasma Ratios (PROPPR) trial was a randomized clinical comparing survival after transfusion of two different blood component ratios for emergency resuscitation traumatic massive hemorrhage. Transfusion services supporting the study were expected to provide thawed plasma, platelets, red cells within 10 minutes request. STUDY DESIGN AND METHODS At 12 Level 1 trauma centers participating in PROPPR, components transfused delivery times...
Background Blood conservation strategies have been shown to be effective in decreasing red blood cell ( RBC ) utilization specific patient groups. However, few data exist describing the extent of transfusion reduction or their impact on practice and mortality a diverse inpatient population. Study Design Methods We conducted retrospective cohort study using comprehensive electronic medical record from 21 facilities K aiser P ermanente N orthern C alifornia. examined unadjusted risk‐adjusted...
BACKGROUND When problems with compatibility beyond ABO and D arise, currently transfusion services search their inventories perform time‐consuming serologic testing to locate antigen‐negative blood. These clinically important blood group antigens can be detected reliably by red cell genotyping, which is a technology whereby DNA‐based techniques are used evaluate gene polymorphisms that determine the expression of antigens. We introduced mass‐scale genotyping measured availability genotyped...
Abstract BACKGROUND Using the Recipient and Donor Epidemiology Study‐III (REDS‐III) recipient donor databases, we performed a retrospective analysis of platelet use in 12 US hospitals that were participants REDS‐III. STUDY DESIGN AND METHODS Data electronically extracted from participating transfusion service blood center computer systems medical records REDS‐III hospitals. All transfusions 2013 to 2016 given patients aged 18 years older included analysis. RESULTS There 28,843 inpatients...
Current transfusion-related acute lung injury reduction strategies include avoiding transfusion of plasma products collected from female donors or that have been pregnant to reduce plasma-containing HLA antibodies. Such a policy considerably decreases the number available for generation fresh-frozen (FFP). To increase supply FFP, substitution 24-hour (FP24) and thawed (TP) derived either FFP FP24 may be viable substitutes. justify such coagulation factor content FP24, TP both product types...
HLA antibody testing of previously transfused or pregnant donors may help reduce the risk transfusion-related acute lung injury (TRALI). However, prevalence antibodies in has not been well characterized.Transfusion and pregnancy history was obtained from consenting donors. Class I II performed by multiantigen bead Luminex platform. Cutoff values for used normalized background ratios 10.8 6.9, respectively. Linear probability models were to evaluate potential associations between...
BACKGROUND: The importance of adverse reactions in terms donor safety recently has received significant attention, but their role subsequent donation behavior not been thoroughly investigated. STUDY DESIGN AND METHODS: Six REDS‐II blood centers provided data for this analysis. Summary minor and major reaction categories were created. influence on was examined two ways: Kaplan‐Meier curves generated to determine the cumulative pattern first return, adjusted odds ratios (AORs) demographic...
Transfusion-associated circulatory overload is characterized by hydrostatic pulmonary edema following blood transfusion. Restrictive transfusion practice may affect the occurrence and severity of transfusion-associated in critically ill patients. We sought to examine contemporary risk factors outcomes for overload.
Detailed information regarding plasma use in the United States is needed to identify opportunities for practice improvement and design of clinical trials therapy.Ten US hospitals collected detailed medical from electronic health records 1 year (2010-2011) all adult patients transfused with plasma.A total 72,167 units were 19,596 doses 9269 patients. The median dose was 2 (interquartile range, 2-4; range 1-72); 15% unit, 45% units. When adjusted by patient body weight (kg), 7.3 mL/kg...
Background The concordance of haemovigilance criteria developed for surveillance transfusion‐associated circulatory overload ( TACO ) with its clinical diagnosis has not been assessed. In a pilot study to evaluate an electronic screening algorithm, we sought examine incidence and application in patients post‐transfusion pulmonary oedema. Study Design Methods From June September 2014, all transfused adult inpatients at four academic hospitals were screened algorithm identifying chest...
Abstract. Platelet concentrates from 290 healthy donors collected in CPD anticoagulant and PL‐146 polyvinylchloride containers were stored for 72 h at 22±0.5°C under standard conditions to investigate variables affecting the quality of platelets. In addition expected inverse relationship between pH platelet count (p < 0.001), a significant correlation white blood cell (WBC) was also noted 0.01). Platelets female developed lower than those male donors; this difference could not be...
Anaplasma phagocytophilum, the causative agent of human granulocytic anaplasmosis, is an obligate intracellular bacterium most commonly acquired from tick bites. High seroprevalence rates in endemic regions suggest that transfusion transmission A phagocytophilum would be a common event; however, only 2 cases have previously been reported. The exact cause this discrepancy not known. Whole blood leukocyte-reduction methods used by many centers are thought to reduce risk pathogens, including...