A5030623241- Combustion and flame dynamics
- Advanced Combustion Engine Technologies
- Fire dynamics and safety research
- Fluid Dynamics and Turbulent Flows
- Combustion and Detonation Processes
- Computational Fluid Dynamics and Aerodynamics
- Selenium in Biological Systems
- Heavy Metal Exposure and Toxicity
- Subcritical and Supercritical Water Processes
- Trace Elements in Health
- Thermochemical Biomass Conversion Processes
- Refrigeration and Air Conditioning Technologies
- Catalysts for Methane Reforming
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Radiative Heat Transfer Studies
- Welding Techniques and Residual Stresses
- Immunotherapy and Immune Responses
- Advanced Surface Polishing Techniques
- Nanoparticles: synthesis and applications
- Biofuel production and bioconversion
- Anaerobic Digestion and Biogas Production
- Phytochemicals and Antioxidant Activities
- Laser Material Processing Techniques
- Biomedical Research and Pathophysiology
Mount Fuji Research Institute
2014-2025
Anjo Kosei Hospital
2025
Mirai Hospital
2024
Center for Cancer Research
2019-2024
Massachusetts General Hospital
2019-2024
Harvard University
2019-2024
Shiseido Group (Japan)
2013-2024
Hokkaido University
2016-2024
Tokai University
1996-2024
Nagoya City University
2017-2023
Cadmium (Cd) causes renal dysfunction with damage to kidney proximal tubule cells; however, the precise mechanisms of toxicity remain unclear. Previously, we found that expression Ube2d4 gene, which is a member ubiquitin-conjugating enzyme Ube2d family, suppressed by Cd in NRK-52E rat tubular epithelial cells. To investigate Cd-induced toxicity, examined effects on ubiquitin-proteasome system, particularly and function family members cells mice. markedly decreased Ube2d1, Ube2d2, Ube2d3...
Database obtained earlier in 3D Direct Numerical Simulations (DNS) of statistically stationary, 1D, planar turbulent flames characterized by three different density ratios σ is processed order to investigate vorticity transformation premixed combustion under conditions moderately weak turbulence (rms velocity and laminar flame speed are roughly equal one another). In cases H M = 7.53 5.0, respectively, anisotropic generation within the brush reported. study physical mechanisms that control...
Luminescent dinuclear Cu(I) complexes, [Cu2X2(dpypp)2] [Cu-X; X = Cl, Br, I; dpypp 2,2′-(phenylphosphinediyl)dipyridine], were successfully synthesized by a solvent-assisted mechanochemical method. A trace amount of the assisting solvent plays key role in synthesis; only two solvents possessing nitrile group, CH3CN and PhCN, effective for promoting formation Cu-X. X-ray analysis revealed that structure with no Cu···Cu interactions, bridged ligands, was commonly formed all Cu-X species. These...
In an attempt to define the role of pineal secretory melatonin and analogue, 6‐hydroxymelatonin (6‐OHM), in limiting oxidative stress, present study investigated cisplatin (CP)‐induced alteration renal antioxidant system nephroprotection with two indolamines. Melatonin (5 mg/kg), 6‐OHM or equal volume saline were administered intraperitoneally (i.p.) male Sprague–Dawley rats 30 min prior i.p. injection CP (7 mg/kg). After treatment, animals each received indolamine every day sacrificed 3 5...
Fenugreek seed ( Trigonella foenum-graecum L.) is used as an herbal medicine for treating metabolic and nutritive dysfunctions. To determine if this plant has other beneficial effects, we tested the inhibitory activities of a methanol (MeOH) extract fenugreek on production inflammatory cytokines melanin synthesis in cultured cell lines vitro. The MeOH inhibited phorbol-12-myristate-13-acetate-induced such tumor necrosis factor (TNF)-α THP-1 cells, also restrained intracellular murine...
Peanut skin (Arachis hypogaea L., Fabaceae) is an abundant source for polyphenols, such as proanthocyanidin oligomers. To determine whether has beneficial effects on skin, we tested inhibitory activity of proanthocyanidins isolated from peanut inflammatory cytokine production and melanin synthesis in cultured cell lines. Administration extract (PSE, 200 µg/mL) decreased melanogenesis human melanoma HMV-II co-stimulated with phorbol-12-myristate-13-acetate. It also cytokines (PSE at 100...
Exposure to nanoparticles during pregnancy is a public concern, because may pass from the mother fetus across placenta. The purpose of this study was determine possible translocation pathway gold maternal-fetal barrier as well toxicity intravenously administered placenta and fetus. Pregnant ICR mice were injected with 0.01% 20- 50-nm nanoparticle solutions on 16th 17th days gestation. There no sign toxic damage placentas maternal fetal organs treated nanoparticles. ICP-MS analysis...
We have synthesized two luminescent mononuclear Cu(I) complexes, [Cu(PPh2Tol)(THF)(4Mepy)2](BF4) (1) and [Cu(PPh2Tol)(4Mepy)3](BF4) (2) (PPh2Tol = diphenyl(o-tolyl)phosphine, 4Mepy 4-methylpyridine, THF tetrahydrofuran), investigated their crystal structures, luminescence properties, vapor-induced ligand exchange reactions in the solid state. Both coordination complexes are tetrahedral, but one of three ligands complex 2 is replaced by a solvent molecule 1. In contrast to very weak blue...
Abstract The ultimate goal of periodontal disease treatment is the reorganization functional tissue that can regenerate lost tissue. Regeneration tissues clinically possible by using autogenic transplantation MSCs. However, autologous MSC limited depending on age, systemic and quality, thus precluding their clinical application. Therefore, we evaluated efficacy allogeneic adipose-derived multi-lineage progenitor cells (ADMPC) in a micro-mini pig defect model. ADMPC were isolated from greater...