A5088550986- Heavy Metal Exposure and Toxicity
- Trace Elements in Health
- Proteoglycans and glycosaminoglycans research
- Cell Adhesion Molecules Research
- Protease and Inhibitor Mechanisms
- Glycosylation and Glycoproteins Research
- Mercury impact and mitigation studies
- Nanoplatforms for cancer theranostics
- Advanced Battery Materials and Technologies
- HER2/EGFR in Cancer Research
- Advancements in Battery Materials
- Photodynamic Therapy Research Studies
- Breast Cancer Treatment Studies
- Fluorine in Organic Chemistry
- Cancer Treatment and Pharmacology
- Heavy metals in environment
- Radiopharmaceutical Chemistry and Applications
- Lung Cancer Treatments and Mutations
- Advanced Breast Cancer Therapies
- Connective tissue disorders research
- Asymmetric Synthesis and Catalysis
- Arsenic contamination and mitigation
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Chemical Synthesis and Analysis
Tokyo University of Pharmacy and Life Sciences
2015-2025
Shinshu University
2015-2024
Toshiba (Japan)
2023
Aichi Gakuin University
2008-2020
National Institute of Technology, Tokyo College
2020
Tokyo National Hospital
2011-2019
National Taiwan University Hospital
2019
Severance Hospital
2019
Yonsei University
2019
National Cancer Centre Singapore
2019
The behavior of cells is generally considered to be regulated by environmental factors, but the molecules in milieu neural stem have been little studied. We found immunohistochemistry that chondroitin sulfate (CS) existed surroundings nestin-positive or stem/progenitor rat ventricular zone telencephalon at embryonic day 14. Brain-specific proteoglycans (CSPGs), including neurocan, phosphacan/receptor-type protein-tyrosine phosphatase beta, and neuroglycan C, were detected zone. Neurospheres...
Cadmium (Cd) causes renal dysfunction with damage to kidney proximal tubule cells; however, the precise mechanisms of toxicity remain unclear. Previously, we found that expression Ube2d4 gene, which is a member ubiquitin-conjugating enzyme Ube2d family, suppressed by Cd in NRK-52E rat tubular epithelial cells. To investigate Cd-induced toxicity, examined effects on ubiquitin-proteasome system, particularly and function family members cells mice. markedly decreased Ube2d1, Ube2d2, Ube2d3...
Syntheses of optically active trifluoromethylated amines via ring-opening reactions N-benzyl-2-trifluoromethylaziridine were achieved. Proton-catalyzed the 2-trifluoromethylaziridine proceeded very smoothly, while compound was found to be inert toward nucleophiles; thus, trifluoromethylaziridine itself cannot ring-opened by nitrogen or carbon nucleophiles. The N-alkylated aziridinium ion highly reactive undergo smooth and
The purpose of the present study was to investigate whether cilostazol, a phosphodiesterase-III inhibitor and antiplatelet drug, would prevent tPA-associated hemorrhagic transformation. Mice subjected 6-h middle cerebral artery occlusion were treated with delayed tPA alone at 6 h, combined plus cilostazol or vehicle h. We used multiple imaging (electron microscopy, spectroscopy), histological neurobehavioral measures assess effects treatment 18 h 7 days after reperfusion. To further...
The regulation of vascular endothelial cell behavior during angiogenesis and in disease by transforming growth factor-β<sub>1</sub>(TGF-β<sub>1</sub>) is complex, but it clearly involves factor-induced changes extracellular matrix synthesis. Proteoglycans (PGs) synthesized cells contribute to the formation also influence cellular proliferation migration. Since effects TGF-β<sub>1</sub>on smooth muscle are dependent on density, possible that TGF-β<sub>1</sub> directs different patterns PG...
The nature of Eu incorporation and resulting luminescence efficiency in GaN has been extensively investigated. By performing a comparative study on GaN:Eu samples grown under variety controlled conditions, using experimental techniques, the configuration majority site concluded to contain nitrogen vacancy (VN). can appear two symmetries, which profound impact magnetic properties sample. structure minority also identified. We propose that, for both sites, excitation red emission is improved...
Atomic-resolution STEM reveals complex ordering of A-site cations and vacancies, as well NbO<sub>6</sub>octahedral tilting distortion, in Li-conducting perovskites La<sub>(1−x)/3</sub>Li<sub>x</sub>NbO<sub>3</sub>.
Lithium lanthanum titanate La2/3-xLi3xTiO3 (LLTO) has the potential to exhibit highest Li-ion conductivity among oxide-based electrolytes because of fast diffusion derived from its crystal structure. Herein, bulk up σbulk = 4.0 × 10-3 S/cm at 300 K, which is approximately three four times higher than that LLTO polycrystals, was demonstrated using single crystals, and their dependence on domain orientation examined. A change in activation energy, previously obscured random orientation,...
Abstract Chronic cadmium (Cd) exposure can induce renal toxicity. In Cd toxicity, p53 is thought to be involved. Our previous studies showed that down-regulated gene expression of the UBE2D (ubiquitin-conjugating enzyme E2D) family members. Here, we aimed define association between members and p53-dependent apoptosis in human proximal tubular cells (HK-2 cells) treated with Cd. increased intracellular protein levels decreased UBE2D2 UBE2D4 via inhibition YY1 FOXF1 transcription factor...
Metallothionein (MT) plays a central role in cellular defense against heavy metals and oxidative stress. Since the induction of MT requires activation metal response element (MRE)-binding transcription factor-1 (MTF-1) by binding zinc ions, inorganic is regarded as typical inducer. However, previous report, we showed that could not induce vascular endothelial cells. While it suggested presents mechanisms different from those other cell types, these remain unclear. In this study, investigated...
The interest in organic–inorganic hybrid molecules as molecular probes for biological systems has been growing rapidly. Such exhibit unique activities. Herein, copper(II) bis(diethyldithiocarbamate) (Cu10) was found to activate the transcription factor NF-E2-related 2 (Nrf2), which is responsible regulating antioxidant and phase II xenobiotic enzymes, vascular endothelial cells. copper complex rapidly accumulated within cells induced nuclear translocation of Nrf2, leading upregulation...
Proteoglycans are macromolecules that consist of a core protein and one or more glycosaminoglycan side chains. A small leucine-rich dermatan sulfate proteoglycan, biglycan, is the predominant types proteoglycans synthesized by vascular endothelial cells; however, physiological functions biglycan not completely understood. In present study, bovine aortic cells in culture were transfected with interfering RNAs for expression other was examined. Transforming growth factor-β1 signaling also...
Cadmium (Cd) is an environmental pollutant that damages various tissues. Cd may cause a depletion of iron stores and subsequently deficiency state in the liver. However, molecular mechanism decreased accumulation liver induced by long-term exposure to unknown. In this study, we investigated hepatic proximal duodenal expression genes involved transport using mice chronically exposed Cd. Five-week-old female C57BL/6J were fed diet containing 300 ppm for 12, 15, 19 21 months. The concentration...
Methylmercury is the causative organometallic compound of Minamata disease. Pathological changes in cerebrum patients are localized along deep sulci and fissures cerebral cortex such as calcarine fissure. It has been suggested that occurrence brain edema important for damage caused by methylmercury. Previously, we found methylmercury induces vascular endothelial growth factor-A cultured human microvascular pericytes, which may increase permeability microvasculature. In present study, our...
While photodynamic therapy (PDT) is an effective treatment for glioma, induction of apoptotic cell death glioma cells important ensuring efficacy and safety PDT in patients, as necrotic can induce late appearance obstacles treatment. Here, we investigated the relationship between type conditions involved laser photosensitizer dosage human glioblastoma T98G cells. Photosensitizer talaporfin sodium-mediated (NPe6-PDT) induced NPe6 dose-dependent cells, whereas almost all pretreated with at ≥...
Abstract The detrimental influence of oxygen on the performance and reliability V/III nitride based devices is well known. However, nature incorporation other co-dopants, such as rare earth ions, has been largely overlooked in GaN. Here, we report first comprehensive study critical role that Eu GaN, atomic scale observation diffusion local concentration both atoms crystal lattice. We find plays an integral location, stability defect structure around ions were doped into GaN host. Although...