A5051362840- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Sepsis Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Respiratory viral infections research
- Hemodynamic Monitoring and Therapy
- COVID-19 Clinical Research Studies
- Intensive Care Unit Cognitive Disorders
- Pneumonia and Respiratory Infections
- Kawasaki Disease and Coronary Complications
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Renal function and acid-base balance
- Family and Patient Care in Intensive Care Units
- Nosocomial Infections in ICU
- Thermal Regulation in Medicine
- Acute Ischemic Stroke Management
- Public Health and Environmental Issues
- Airway Management and Intubation Techniques
- COVID-19 and Mental Health
- Congenital Diaphragmatic Hernia Studies
- Pleural and Pulmonary Diseases
- Health and Medical Education
- Trauma and Emergency Care Studies
- Venous Thromboembolism Diagnosis and Management
Finis Terrae University
2021-2024
RedCLARA
2020-2024
Universidad Nacional de Colombia
2020-2024
Research Network (United States)
2022-2024
Facultad Latinoamericana de Ciencias Sociales
2021-2024
Asociación Colombiana de Diabetes
2023
Universidad del Desarrollo
2008-2022
University of Chile
2021
Hospital Carmen y Severo Ochoa
2020
Clínica Alemana
2008-2020
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, disproportionally affects adults (children <5% in most reports).1 Adult critical illness is characterized hypoxemia, multiorgan failure, and high mortality.2,3 Reported risk factors for include age, cardiorespiratory comorbidities, obesity, laboratory findings (lymphopenia elevated D-dimer).2,4 Pediatric reports describe low infection rates infrequent PICU admission.5,6 The largest report consists...
Background The COVID-19 pandemic reached the Southern Hemisphere in autumn of 2020, thus coinciding with its expected annual viral respiratory season. potential impact national strategies aimed at mitigating during on incidence other critical lower tract infections (LRTIs) children is unknown. Methods We analysed admission data for LRTIs from 22 paediatric intensive care units (PICUs) four countries, part a large international Latin American registry acute failure (Red Colaborativa...
To understand critical paediatric coronavirus disease 2019 (COVID-19) and evaluate factors associated with mortality in children from high low-middle income countries.Prospective, observational study of critically ill hospitalised for COVID-19 18 countries throughout North America, Latin Europe between April 1 December 31, 2020. Associations were evaluated using logistic regression.557 patients (median age, 8 years; 24% <2 years) enrolled 55 sites (63% American). Half had comorbidities....
The worldwide practice and impact of noninvasive ventilation (NIV) in pediatric acute respiratory distress syndrome (PARDS) is unknown. We sought to describe NIV use associated clinical outcomes PARDS.
Objectives: To determine the prevalence of respiratory bacterial codetection in children younger than 2 years intubated for acute lower tract infection (LRTI), primarily viral bronchiolitis, and identify association with mechanical ventilation duration. Design: Prospective observational study evaluating (moderate/heavy growth pathogenic plus moderate/many polymorphonuclear neutrophils) impact on invasive (IMV) Setting: PICUs 12 high low/middle-income countries. Patients: Children old...
Protective mechanical ventilation (MV) aims at limiting global lung deformation and has been associated with better clinical outcomes in acute respiratory distress syndrome (ARDS) patients. In ARDS lungs without MV support, the mechanisms evolution of tissue remain understudied. this work, we quantify progression heterogeneity regional strain injured under spontaneous breathing MV.Lung injury was induced by lavage murine subjects, followed 3 h (SB-group) or low Vt (MV-group). Micro-CT images...
To describe the editorial processing time of published COVID-19 research articles and compare this with a similar topic, human influenza, analyze number publications, withdrawals, retractions.A descriptive-analytical study using PubMed on MeSH terms influenza COVID-19. Time to acceptance (from submission acceptance) publication publication) were compared. Retractions withdrawals reviewed both qualitatively quantitatively.There 31 319 4 287 during 2020. The median for was lower than that (8...
Abstract Background Mechanical power is a composite variable for energy transmitted to the respiratory system over time that may better capture risk ventilator-induced lung injury than individual ventilator management components. We sought evaluate if mechanical ventilation with high associated fewer ventilator-free days (VFD) in children pediatric acute distress syndrome (PARDS). Methods Retrospective analysis of prospective observational international cohort study. Results There were 306...
OBJECTIVES: To examine frictional, viscoelastic, and elastic resistive components, as well threshold pressures, during volume-controlled ventilation (VCV) pressure-controlled (PCV) in pediatric patients with acute respiratory distress syndrome (ARDS). DESIGN: Prospective cohort study. SETTING: Seven-bed PICU, Hospital El Carmen de Maipú, Chile. PATIENTS: Eighteen mechanically ventilated less than or equal to 15 years old undergoing neuromuscular blockade part of management for ARDS....
Durante la pandemia de COVID-19, las infecciones respiratorias pediátricas disminuyeron drásticamente a nivel mundial. Sin embargo, en el otoño-invierno 2023, estas enfermedades resurgieron manera inusual, causando estrés sistema salud. Comparando los datos del 2023 con quinquenio prepandemia Departamento Estadísticas e Información Salud (DEIS) Chile, observamos que magnitud y frecuencia fueron similares. No obstante, salud se debió al inicio temprano demanda, sincronicidad grupos etarios,...
Little is known about the efficacy and safety of recruitment maneuvers (RMs) in pediatric patients with acute respiratory distress syndrome (ARDS). We therefore assessed effects on gas exchange lung mechanics possible detrimental a sequential RMs decremental positive end-expiratory pressure (PEEP) titration ARDS patients.We enrolled <15 years age ARDS, progressive hypoxemia, <72 hr mechanical ventilation, hemodynamic stability. A step-wise RM PEEP trial were performed. Safety was evaluated...
Pulse pressure variation (PPV) and stroke volume (SVV) are frequently used to assess fluid responsiveness in critically ill patients on mechanical ventilation (MV). There many factors, addition preload that influence the magnitude of these cyclic variations. We sought investigate effect tidal (VT) PPV SVV, prediction a model intra-abdominal hypertension (IAH). Twelve anesthetized mechanically ventilated piglets continuous pulse contour cardiac output monitoring. Hypovolemia was ruled out...
Fluid overload (FO) is associated with unfavorable outcomes in critically ill children. Clinicians are encouraged to avoid FO; however, strategies FO not well-described pediatrics. Our aim was implement a bundle strategy prevent children sepsis and pARDS compare the historical cohort.A quality improvement initiative, known as preemptive fluid (PFS) implemented early FO, 12-bed general PICU. Infants on mechanical ventilation (MV) fulfilling criteria were prospectively recruited. For...
American Cutaneous Leishmaniasis (ACL) is an endemic disease in most Latin-American countries and a public health problem. The number of new cases the world thought to be about 1.5 million each year. A epidemiologic pattern has been observed last years, this sense, Geographic Information Systems (GIS) combined with methods spatial analysis provide powerful tools for understanding it. To investigate temporal features Leishmaniasis, area known endemic. We retrospectively conducted space–time...
Objective: The aim of this study was to develop evidence-based recommendations for the diagnosis and treatment sepsis in children low- middle-income countries (LMICs), more specifically Latin America. Design: A panel formed consisting 27 experts with experience pediatric two methodologists working American countries. were organized into 10 nominal groups, each coordinated by a member. Methods: formal consensus based on modified Delphi method, combining opinions groups interpretation...
Analysis of respiratory mechanics during mechanical ventilation (MV) is able to estimate resistive, elastic and inertial components the working pressure system. Our aim was discriminate system in infants on MV with severe bronchiolitis admitted two PICU's. Infants younger than 1 year old acute failure caused by underwent neuromuscular blockade, tracheal intubation volume controlled MV. Shortly after studies pulmonary were performed using inspiratory expiratory breath hold. The maximum flow...