A5026559418- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Neonatal and Maternal Infections
- Bacterial Infections and Vaccines
- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- Tracheal and airway disorders
- Antibiotic Use and Resistance
- Pneumocystis jirovecii pneumonia detection and treatment
- Congenital Diaphragmatic Hernia Studies
- Maternal and Neonatal Healthcare
- Vaccine Coverage and Hesitancy
- HIV/AIDS Research and Interventions
- Streptococcal Infections and Treatments
- Bacterial biofilms and quorum sensing
- Neonatal Respiratory Health Research
- HIV Research and Treatment
- Viral gastroenteritis research and epidemiology
- HIV/AIDS drug development and treatment
- Antibiotic Resistance in Bacteria
- Sepsis Diagnosis and Treatment
- Nosocomial Infections in ICU
- Emergency and Acute Care Studies
- Virology and Viral Diseases
- Global Maternal and Child Health
Faculdade de Ciências Médicas da Santa Casa de São Paulo
2014-2025
Moscow Polytechnic University
2023-2024
Santa Casa Hospital
2007-2021
Irmandade da Santa Casa de Misericórdia de São Paulo
2006-2020
Universidade de São Paulo
2018
Hospital São Paulo
2010-2018
Pediatric Infectious Diseases Society
2009-2014
Yahoo (United Kingdom)
2014
Inria Chile
2011
Czech Academy of Sciences, Institute of Microbiology
2009
Background There is limited data on antibiotic treatment in hospitalized neonates low- and middle-income countries (LMICs). We aimed to describe patterns of use, pathogens, clinical outcomes, develop a severity score predicting mortality neonatal sepsis inform future trial design. Methods findings Hospitalized infants <60 days with were enrolled during 2018 2020 by 19 sites 11 (mainly Asia Africa). Prospective daily observational was collected signs, supportive care, treatment,...
Invasive candidiasis is increasingly prevalent in premature infants and seriously ill children, pediatric data on available antifungal therapies are lacking.We conducted a substudy as part of double-blind, randomized, multinational trial to compare micafungin (2 mg/kg) with liposomal amphotericin B (3 first-line treatment invasive candidiasis. Treatment success was defined clinical mycologic response at the end therapy. Statistical analyses were descriptive, sample size meant that study not...
To gain an understanding of the variation in available resources and clinical practices between neonatal units (NNUs) low-income middle-income country (LMIC) setting to inform design observational study on burden unit-level antimicrobial resistance (AMR).A web-based survey using a REDCap database was circulated NNUs participating Neonatal AMR research network. The included questions about NNU funding structure, size, admission rates, access supportive therapies, empirical guidelines period...
Brazil implemented routine immunization with the human rotavirus vaccine, Rotarix, in 2006 and vaccination coverage reached 81% 2008 São Paulo. Our aim was to assess impact of on incidence severe acute gastroenteritis (AGE).We performed a 5-year (2004-2008) prospective surveillance at sentinel hospital Paulo, testing for all children less than 5 years age hospitalized AGE. Genotypes positive samples were determined by reverse transcription polymerase chain reaction.During study, 655 AGE...
Abstract Gram-negative bacteria (GNB) are a major cause of neonatal sepsis in low- and middle-income countries (LMICs). Although the World Health Organization (WHO) reports that over 80% these deaths could be prevented through improved treatment, efficacy currently recommended first- second-line treatment regimens for this condition is increasingly affected by high rates drug resistance. Here we assess three well known antibiotics, fosfomycin, flomoxef amikacin, combination as potential...
Abstract Background Neonatal sepsis is a leading cause of child mortality, and increasing antimicrobial resistance threatens progress towards the Sustainable Development Goals. Evidence to guide antibiotic treatment for in neonates young infants from randomized controlled trials or observational studies low- middle-income countries (LMICs) scarce. We aimed describe patterns use, pathogens outcomes LMIC hospital settings globally inform future clinical on management neonatal sepsis. Methods...
Knowledge about antimicrobial resistance patterns of the etiological agents urinary tract infections (UTIs) is essential for appropriate therapy. Urinary isolates from symptomatic UTI cases attended at Santa Casa University Hospital São Paulo August 1986 to December 1989 and 2004 2005 were identified by conventional methods. Antimicrobial testing was performed Kirby Bauer's disc diffusion method. Among 257 children, E. coli found in 77%. A high prevalence observed against ampicillin TMP/SMX...
We evaluated the performance of several methods for detection methicillin resistance in Staphylococcus aureus using 101 clinical S. isolates from pediatric patients a tertiary hospital Brazil; 50 were mecA-positive and 51 mecA-negative. The Etest oxacillin agar screening plates 100% sensitive specific mecA presence. Oxacillin cefoxitin disks gave sensitivities 96 92%, respectively, 98% specificity. Alterations CLSI breakpoints increased sensitivity to 98%, without decreasing Our results...
The purpose of this study was to identify the rate infections due RSV and other viruses in children. In addition we have analyzed demographic data clinical characteristics RSV-positive patients comparing with infected by respiratory viruses. We also described seasonality occurrence a hospital São Paulo. Children below 5 years old admitted Santa Casa de Paulo Hospital between February 2005 September 2006 acute (ARI) were included. A nasopharyngeal specimens obtained sterile No. French feeding...
Pneumococcal (Pnc) carriage is associated with pneumococcal diseases. Breast feeding and maternal vaccination may be a useful approach to prevent infection in young infants. We examined the risk of Pnc by infants at six months age after polysaccharide pregnant women. selected 139 woman. The woman were randomly allocated receive 23-valent vaccines during pregnancy (Group 1) 2) or not any vaccine 3). Nasopharyngeal swabs collected from three age. evaluated monthly first months. included 47...
Background Monitoring the impact of vaccine programs is necessary to identify changes in efficacy. We report 12-year rotavirus program on diarrhea mortality and hospitalizations their correlation socioeconomic indicators.Methods this ecological study describes deaths from 2006 2018 Brazil correlates coverage, indicators social vulnerability index (SVI) by state region. Hospitalizations, deaths, coverage trends were analyzed using Joinpoint regression models. Associations between...
HIV drug resistance genotype testing, performed on 39 HIV-infected treatment-naive children from 2000 to 2011, identified 5 (12.8%) with mutations: 5.3% nucleoside reverse transcriptase inhibitors, nonnucleoside inhibitors and 7.7% protease inhibitors. There was a trend for increasing prevalence of mutations during the 11-year study period.
It is well established that respiratory viruses are an important cause of hospitalizations in young children worldwide, but data limited on the contribution specific to severe illness South America. We describe clinical and laboratory findings from prospective surveillance for acute infections at a tertiary hospital São Paulo, Brazil.We screened < 2 years old with tract admitted urban March 2008 through February 2010, using polymerase chain reaction assays.Respiratory were identified 378...
Human parainfluenza viruses account for a significant proportion of lower respiratory tract infections in children. To assess the prevalence as cause acute infection and to compare clinical data this against those human syncytial virus. A prospective study children younger than five years with was conducted. Detection nasopharyngeal aspirate samples performed using indirect immunofluorescence reaction. Length hospital stay, age, history physical exam, diagnoses, evolution (admission...
The aim of this study was to identify the risk factors for nosocomial bloodstream infections by multidrug resistant Gram-negative bacilli. From November 2001 December 2003, in Pediatric Department Santa Casa de São Paulo, a retrospective case-control developed concerning patients who had infection caused Patients with were designated as case patients, and control those an that did not meet criteria resistance. Previous use central venous catheter previous vancomycin plus third generation...