A5055158819- Bacterial Infections and Vaccines
- Antibiotic Resistance in Bacteria
- Pneumonia and Respiratory Infections
- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- Neonatal and Maternal Infections
- Metabolism and Genetic Disorders
- Antibiotics Pharmacokinetics and Efficacy
- Blood Coagulation and Thrombosis Mechanisms
- Lipoproteins and Cardiovascular Health
- Global Health Workforce Issues
- Congenital Diaphragmatic Hernia Studies
- Primary Care and Health Outcomes
- Renal Diseases and Glomerulopathies
- Congenital Heart Disease Studies
- Neonatal Respiratory Health Research
- Vitamin D Research Studies
- Mechanical Circulatory Support Devices
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Pituitary Gland Disorders and Treatments
- Innovations in Medical Education
- Bacterial Identification and Susceptibility Testing
- Research studies in Vietnam
- Nosocomial Infections in ICU
- Cardiac Structural Anomalies and Repair
National Hospital of Pediatrics
2009-2025
Children's Hospital 1
2023-2025
Hospital for Tropical Diseases
2022
Vietnam National University, Hanoi
2021
Ministry of Health
2019
Abstract Neonatal invasive candidiasis (NIC) has significant morbidity and mortality. Reports have shown a different profile of those neonates affected with NIC fluconazole-resistant Candida spp. isolates in low- middle-income countries (LMICs) compared to high-income (HICs). We describe the epidemiology, distribution, treatment, outcomes from LMICs enrolled global, prospective, longitudinal, observational cohort study (NeoOBS) hospitalized infants <60 days postnatal age sepsis...
Background: Sitosterolemia is a rare autosomal recessive disorder characterized by diverse clinical manifestations ranging from asymptomatic cases to the development of xanthomas, hypercholesterolemia, premature atherosclerosis, or even sudden death during childhood. It results homozygous compound heterozygous pathogenic variants in ABCG5 ABCG8 genes. Prompt detection and intervention are essential managing this condition preventing severe outcomes. Methods: This study aims retrospectively...
Background: Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency (HMGCS2D) is a rare metabolic disorder that impairs the body's ability to produce ketone bodies and regulate energy metabolism. Diagnosing HMGCS2D challenging because patients typically remain asymptomatic unless experiencing fasting or illness. Due absence of reliable biochemical markers, genetic testing has become definitive method for diagnosing HMGCS2D. Methods: This study included 19 from 14 unrelated...
Abstract Background Neonatal sepsis is a leading cause of child mortality, and increasing antimicrobial resistance threatens progress towards the Sustainable Development Goals. Evidence to guide antibiotic treatment for in neonates young infants from randomized controlled trials or observational studies low- middle-income countries (LMICs) scarce. We aimed describe patterns use, pathogens outcomes LMIC hospital settings globally inform future clinical on management neonatal sepsis. Methods...
Abstract Background Carbapenem-resistant Klebsiella pneumoniae are becoming increasingly common in hospital settings worldwide and a source of increased morbidity, mortality health care costs. The global epidemiology carbapenem-resistant K. is characterized by different strains distributed geographically, with the strain ST258 being predominant Europe USA, ST11 most East Asia. ST15 less frequently occurring but has nevertheless been reported as outbreaks . Methods In this study, whole-genome...
Abstract Background The increasing prevalence of carbapenem-resistant Enterobacteriaceae (CRE) is a growing problem globally, particularly in low- to middle-income countries (LMICs). Previous studies have shown high rates CRE colonisation among patients at hospitals LMICs, with increased risk hospital-acquired infections. Methods We isolated Klebsiella pneumoniae (CRKP) from faecal samples collected 2017 admission and discharge Vietnamese neonatal intensive care unit (NICU). 126 CRKP were...
An advisory board meeting was held with experts in Vietnam (Hanoi, August 2022), to review the evidence on invasive meningococcal disease (IMD) epidemiology, clinical management, and vaccines reach a consensus recommendations for vaccination Vietnam. IMD is severe disease, highest burden infants children. presents as meningitis and/or meningococcemia can progress extremely rapidly. Almost 90% of deaths children occur within first 24 h, disabling sequelae (e.g., limb amputations neurological...
Background/Objectives: Hypopituitarism is a condition characterized by the deficiency of several hormones produced pituitary gland. Genetic factors play an important role. Variants in POU1F1 gene are associated with combined hormone deficiency-1 (CPHD1), which manifests as deficiencies growth (GH), thyroid-stimulating (TSH), and prolactin (PRL). This study aimed to analyze phenotype, genotype, treatment, outcomes Vietnamese patients deficiency. Methods: Six from five unrelated families,...
Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency (HMGCS2D) is a rare metabolic disorder that impairs the body's ability to produce ketone bodies and regulate energy metabolism. Diagnosing HMGCS2D challenging because patients typically remain asymptomatic unless they experience fasting or illness. Due absence of reliable biochemical markers, genetic testing has become definitive method for diagnosing HMGCS2D. This study included 19 from 14 unrelated families diagnosed with in...
Abstract: The importance of management competencies among pediatric nurse managers cannot be overstated. In Vietnam, there is a significant lack structured training programs tailored to the specific required by managers. Furthermore, existing comprehensive evaluation their effectiveness. This study aimed assess feasibility competency-based program developed improve capabilities in Vietnam. A one-group pretest-posttest intervention was conducted with eligible from two and...
Vitamin D-dependent rickets type 1A (VDDR1A) is a rare autosomal recessive disorder caused by mutations in the CYP27B1 gene, leading to deficiency active vitamin D (1,25-dihydroxyvitamin D). This study examines genotypic and phenotypic characteristics of VDDR1A Vietnamese children. A retrospective analysis was conducted on 19 children diagnosed with VDDR1A. Clinical, radiological, biochemical, molecular data were collected. Rickets severity score (RSS), biochemical parameters, height...
Hypopituitarism is a condition characterized by the deficiency of several hormones produced pituitary gland. Genetic factors play an important role. Variants in POU1F1 gene are associated with combined hormone 1 (CPHD1), which manifests as deficiencies growth (GH), thyroid-stimulating (TSH), and prolactin (PRL). This study aimed to analyze phenotype, genotype, treatment, outcomes Vietnamese patients deficiency. Six from five unrelated families, initially diagnosed hypopituitarism, were...
Background: Vitamin D-dependent rickets type 1A (VDDR1A) is a rare autosomal recessive disorder caused by mutations in the CYP27B1 gene, leading to deficiency active vitamin D (1,25-dihydroxyvitamin D). This study examines genotypic and phenotypic characteristics of VDDR1A Vietnamese children. Patients Methods: A retrospective analysis was conducted on 19 children diagnosed with VDDR1A. Clinical, radiological, biochemical, molecular data were collected. Rickets Severity Scores (RSSs),...
Simple virilizing congenital adrenal hyperplasia (SV-CAH) due to 21-hydroxylase deficiency (21-OHD) is an autosomal recessive disease caused by pathogenic variants of the CYP21A2 gene. Children with SV-CAH often experience delayed diagnosis, presenting pseudo-precocious puberty in males and genital virilization females. Genotyping essential for treatment, optimization phenotype prediction. This study describes clinical genetic characteristics guide treatment strategies. From November 2016...
Abstract Background The COVID-19 pandemic and the resulting isolation measures created an increase in usage of smart devices internet among adolescents. This study aims to estimate prevalence addiction, high level anxiety as well examine factors associated with adolescents Hanoi, Vietnam during pandemic. Method Data was collected using respondent-driven sampling Google online survey forms from a sample 5,325 school students aged 11–17 Hanoi between October December 2021. A short scale...
The aim of this work was to report the technique and result thoracoscopic repair for a newborn with congenital diaphragmatic hernia (CDH) under high-frequency oscillatory ventilation (HFOV) in neonatal intensive care unit (NICU).Ventilation supported by HFOV. patient placed right lateral decubitus position. Thoracoscopic surgery performed through three 5-mm trocars. Carbon dioxide insufflation maintained thoracic cavity at pressure 6-8 mm Hg. defect repaired using interrupted sutures...
Pertussis is an infectious disease that causes epidemics and outbreaks associated with a high mortality rate, especially in infants, both developed developing countries. We aimed to characterize infants pertussis respiratory failure shock investigated the factors related mortality.A retrospective, observational study conducted between January 2015 October 2020.This was at Vietnam National Children's Hospital, which government hospital serves as tertiary care center Hanoi, Vietnam.Children...
The ECHO (Extension for Community Health Outcomes) model has been introduced and implemented in several hospitals health programs Vietnam since 2015. In 2018, National Children’s Hospital (VNCH) officially the to provide continuing medical education (CME) credits on pediatrics topics staff its satellite centers Northern region of Vietnam. This paper presents preliminary results program at VNCH. Methods included pre- post-program assessments pediatricians’ clinical knowledge, self-efficacy,...
Background Neonatal diabetes mellitus (NDM) is defined as insulin-requiring persistent hyperglycemia occurring within the first 6 months of life, which can result from mutations in at least 25 different genes. Activating heterozygous genes encoding either subunits ATP-sensitive K + channel (K ATP channel; KCNJ11 or ABCC8 ) pancreatic beta cell are most common cause permanent NDM and second transient NDM. Patients with caused by sensitive to sulfonylurea (SU) treatment; therefore, their...
Objective: Data on the management and outcomes of acute myocarditis treated with extracorporeal membrane oxygenation (ECMO) among low- middle-income countries are limited. This study aimed to determine short-term also identify factors associated ECMO use children at a tertiary children's hospital in Vietnam. Methods: A single-center, retrospective observational was conducted between January 2016 February 2021. Pediatric patients myocarditis, aged 1 month 16 years, were included. Results: In...
Wilson disease (WD) is caused by mutations in the copper-transporting P-type adenosine triphosphatase encoded
Invasive meningococcal disease (IMD) imposes a significant burden on the global community due to its high case fatality rate (4-20%) and risk of long-term sequelae for one in five survivors. An expert group meeting was held discuss epidemiology IMD immunization policies Malaysia, Philippines, Thailand, Vietnam. Most these countries do not include their routine vaccination programs, except high-risk groups such as immunocompromised people pilgrims. It is difficult estimate highly diverse...
The Project Extension for Community Healthcare Outcomes (ECHO) model is considered a platform academic medical centers to expand their healthcare workforce capacity medically underserved populations. It has been known as an effective solution of continuing education (CME) workers that used hub-and-spoke leverage knowledge from specialists primary providers in different regions. In this study, we aim explore the views and hospital leaders regarding feasibility, acceptability, sustainability...
Polymerase chain reaction (PCR) is highly sensitive and thus the standard method for diagnosing pertussis. Real-time PCR widely used because of its accuracy simplicity simultaneous cycle threshold (Ct) value, which represents copy numbers target gene. Little known association Ct value with pertussis severity in neonates infants.This study determined values infants diagnosed by real-time using nasopharyngeal samples at Vietnam National Children's Hospital Hanoi 2017 2019. The disease clinical...