Cristina Gardonyi Carvalheiro

ORCID: 0000-0003-1248-472X
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About
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Research Areas
  • Toxoplasma gondii Research Studies
  • Cytomegalovirus and herpesvirus research
  • Neonatal and Maternal Infections
  • Herpesvirus Infections and Treatments
  • Sepsis Diagnosis and Treatment
  • Rabies epidemiology and control
  • Antibiotic Use and Resistance
  • Parasitic Infections and Diagnostics
  • Antibiotic Resistance in Bacteria
  • Streptococcal Infections and Treatments
  • Neonatal and fetal brain pathology
  • Global Maternal and Child Health
  • Hearing, Cochlea, Tinnitus, Genetics
  • Antibiotics Pharmacokinetics and Efficacy
  • Parvovirus B19 Infection Studies
  • Health disparities and outcomes
  • Neonatal Respiratory Health Research
  • Animal Virus Infections Studies
  • Neonatal Health and Biochemistry
  • Climate Change and Health Impacts
  • Cystic Fibrosis Research Advances
  • Complementary and Alternative Medicine Studies
  • SARS-CoV-2 and COVID-19 Research
  • Fungal Infections and Studies
  • Esophageal and GI Pathology

Universidade de São Paulo
2005-2024

Institute for Health Metrics and Evaluation
2024

University of Washington
2024

Pediatrics and Genetics
2024

Universidade de Ribeirão Preto
2021-2023

National Institutes of Health
2021

National Institute of Allergy and Infectious Diseases
2021

Background There is limited data on antibiotic treatment in hospitalized neonates low- and middle-income countries (LMICs). We aimed to describe patterns of use, pathogens, clinical outcomes, develop a severity score predicting mortality neonatal sepsis inform future trial design. Methods findings Hospitalized infants <60 days with were enrolled during 2018 2020 by 19 sites 11 (mainly Asia Africa). Prospective daily observational was collected signs, supportive care, treatment,...

10.1371/journal.pmed.1004179 article EN cc-by PLoS Medicine 2023-06-08

Background: The burden of congenital cytomegalovirus (CMV)-associated sensorineural hearing loss (SNHL) in populations with CMV seroprevalence approaching 100% is unknown. purpose this study was to assess the rate, associated factors, and predictors SNHL CMV-infected infants identified by newborn screening a highly seropositive maternal population. Methods: Newborns positive saliva CMV-DNA that confirmed virus isolation first 2 weeks life were enrolled prospective follow-up monitor outcome....

10.1097/inf.0b013e31822d9640 article EN The Pediatric Infectious Disease Journal 2011-08-03

Abstract Neonatal invasive candidiasis (NIC) has significant morbidity and mortality. Reports have shown a different profile of those neonates affected with NIC fluconazole-resistant Candida spp. isolates in low- middle-income countries (LMICs) compared to high-income (HICs). We describe the epidemiology, distribution, treatment, outcomes from LMICs enrolled global, prospective, longitudinal, observational cohort study (NeoOBS) hospitalized infants <60 days postnatal age sepsis...

10.1093/mmy/myad010 article EN cc-by Medical Mycology 2023-03-01

Abstract Gram-negative bacteria (GNB) are a major cause of neonatal sepsis in low- and middle-income countries (LMICs). Although the World Health Organization (WHO) reports that over 80% these deaths could be prevented through improved treatment, efficacy currently recommended first- second-line treatment regimens for this condition is increasingly affected by high rates drug resistance. Here we assess three well known antibiotics, fosfomycin, flomoxef amikacin, combination as potential...

10.1038/s41467-024-48296-z article EN cc-by Nature Communications 2024-05-10

Abstract Background Neonatal sepsis is a leading cause of child mortality, and increasing antimicrobial resistance threatens progress towards the Sustainable Development Goals. Evidence to guide antibiotic treatment for in neonates young infants from randomized controlled trials or observational studies low- middle-income countries (LMICs) scarce. We aimed describe patterns use, pathogens outcomes LMIC hospital settings globally inform future clinical on management neonatal sepsis. Methods...

10.1101/2022.06.20.22276674 preprint EN medRxiv (Cold Spring Harbor Laboratory) 2022-06-23

A diverse group of professionals gathered in Brasília for the VI Brazilian Symposium on Toxoplasmosis and III International from October 17 to 19, 2023. Guided by ‘One Health’ concept, event addressed toxoplasmosis its human, animal, environmental dimensions. Participants discussed strategies improve prevention, diagnosis, treatment disease Brazil, also emphasizing a Pan-American cooperation. The resulting document, Letter: Proposal Control Brazil with Multidisciplinary Approach Cooperation...

10.17696/2318-3691.31.01.2025.259 article EN Arquivos de Ciências da Saúde 2025-01-31

Congenital toxoplasmosis is rarely identified by routine clinical examination. The aim of this study was to estimate the incidence disease in region Ribeirão Preto, south-eastern Brazil. A definitive diagnosis made on basis persistence anti-Toxoplasma IgG antibodies beyond 1 year age. Blood samples obtained from 15,162 neonates and adsorbed onto filter paper were tested for IgM antibodies. Fifteen gave positive results. confirmed five 13 infants (38.5%) who completed follow-up. These...

10.1017/s095026880400353x article EN Epidemiology and Infection 2005-02-16

Abstract Objectives To estimate, by neonatal screening, the birth prevalence of congenital toxoplasmosis among live‐born infants in Sergipe state, Brazil, and to investigate clinical features affected infants. Methods Dried blood spot specimens obtained from 15 204 neonates were assayed for presence anti‐ T. gondii IgM antibodies. Duplicate retesting was done with positive borderline results. Confirmatory testing peripheral samples consisted IgG mothers. Those possible evaluated followed up...

10.1111/j.1365-3156.2012.03079.x article EN Tropical Medicine & International Health 2012-09-14

Neonatal sepsis is a significant cause of mortality and morbidity in low- middle-income countries. To deliver high-quality data studies inform future trials, it crucial to understand the challenges encountered when managing global multi-centre research identify solutions that can feasibly be implemented these settings. This paper provides an overview complexities faced by diverse teams different countries regions, together with actions achieve pragmatic study management large observational...

10.3390/antibiotics12050923 article EN cc-by Antibiotics 2023-05-17

The severity of toxoplasmosis depends on a combination host and parasite factors. Among them, the Toxoplasma strain causing infection is an important determinant disease outcome. Type 2 strains dominate in Europe, whereas North America type 2, followed by 3 12 are commonly isolated from wildlife patients. To identify person infected with, serological typing provides promising alternative to often risky not always possible biopsy-based DNA methods genotyping. However, despite recent advances...

10.3389/fcimb.2021.621738 article EN cc-by Frontiers in Cellular and Infection Microbiology 2021-02-19

Abstract Background Sepsis severity scores are used in clinical practice and trials to define risk groups. There limited data derive hospital-based sepsis for neonates young infants high-burden low- middle-income country (LMIC) settings where urgently required. We aimed create linked recovery applicable hospitalized LMIC which could be inform antibiotic trials. Methods & Findings A prospective observational cohort study was conducted across 19 hospitals 11 countries sub-Saharan Africa,...

10.1101/2022.06.21.22276677 preprint EN medRxiv (Cold Spring Harbor Laboratory) 2022-06-27

Background: Data on the burden and etiology of neonatal early-onset bacterial sepsis (EOBS) in low-to-middle-income countries are scarce. Surveillance is critical for optimizing prevention treatment strategies. We aimed to estimate incidence EOBS 2 large Brazilian cohorts neonates. Methods: were retrospectively obtained from 33,794 neonates born between 2009 2017 at low-risk (n = 17,981) high-risk maternity centers 15,813). Blood cultures taken within 72 hours life with perinatal risk...

10.1097/inf.0000000000004196 article EN The Pediatric Infectious Disease Journal 2024-01-18

Herein we describe a mild symptomatic real-time reverse transcriptase- polymerase chain reaction-confirmed coronavirus 2 (SARS-CoV-2) infection in pregnant woman who gave birth to preterm infant, 32 weeks gestational age. The neonate was immediately isolated after delivery and developed severe respiratory disease that progressed multisystem inflammatory syndrome death on the seventh day of life. Genome sequencing detected P.1 (gamma) variant samples obtained at hospital admission (mother)...

10.1016/j.bjid.2022.102385 article EN cc-by The Brazilian Journal of Infectious Diseases 2022-07-01

Background: Neonatal sepsis is associated with high mortality, but there limited clinical data on outcomes in hospital facilities low and middle income countries (LMIC). The NeoOBS study aimed to determine the features, pathogens of infants presenting neonatal hospitals globally.Methods: Infants <60 days age, fulfilling at least 2 criteria were enrolled across 19 sites 11 countries, prospective collection 28 days. A multivariable Cox regression model was built predict mortality develop a...

10.2139/ssrn.3864901 article EN SSRN Electronic Journal 2021-01-01

Abstract Objectives Several recent studies highlight the high prevalence of resistance to multiple antibiotic classes used in current treatment regimens for neonatal sepsis and new options are urgently needed. We aimed identify potential combination by investigating drug-resistance genetic profiles most frequently isolated Gram-negative bacteria causing low- middle-income countries (LMICs) NeoOBS study. Material methods from neonates with culture-confirmed 13 clinical sites nine countries,...

10.1101/2023.10.20.23296805 preprint EN cc-by-nd medRxiv (Cold Spring Harbor Laboratory) 2023-10-24
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