A5029645484- Antibiotic Resistance in Bacteria
- Antibiotics Pharmacokinetics and Efficacy
- Bacterial Identification and Susceptibility Testing
- Neonatal and Maternal Infections
- Pneumonia and Respiratory Infections
- Antibiotic Use and Resistance
- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Nosocomial Infections in ICU
- Respiratory viral infections research
- Clostridium difficile and Clostridium perfringens research
- Infectious Diseases and Tuberculosis
- Pancreatitis Pathology and Treatment
- Bacterial biofilms and quorum sensing
- Orthopedic Infections and Treatments
- Diverticular Disease and Complications
- Microscopic Colitis
- Pneumocystis jirovecii pneumonia detection and treatment
- Systemic Sclerosis and Related Diseases
- Infections and bacterial resistance
- Viral gastroenteritis research and epidemiology
- Tracheal and airway disorders
- Mycotoxins in Agriculture and Food
- Enterobacteriaceae and Cronobacter Research
- Renal Transplantation Outcomes and Treatments
Ippokrateio General Hospital of Thessaloniki
2024-2025
Hippocration General Hospital
2019-2025
Aristotle University of Thessaloniki
2021-2023
University of Thessaly
2023
Abstract Gram-negative bacteria (GNB) are a major cause of neonatal sepsis in low- and middle-income countries (LMICs). Although the World Health Organization (WHO) reports that over 80% these deaths could be prevented through improved treatment, efficacy currently recommended first- second-line treatment regimens for this condition is increasingly affected by high rates drug resistance. Here we assess three well known antibiotics, fosfomycin, flomoxef amikacin, combination as potential...
Introduction: The epidemiology of candidemia has shifted in the past few decades; drug-resistant non-albicans Candida species have become more prevalent worldwide. aim this retrospective study was to determine isolated from hospitalized neonates, children and adults, investigate a potential changing susceptibility pattern large general tertiary hospital. Methods: All unique strains cases between 1 January 2020 15 October 2024 were identified, their profile characterized. distribution...
Emergence of extensively drug-resistant (XDR) or pan (PDR) Enterobacteriaceae is a major public threat especially for young patients. Treatment options these bacteria are extremely limited with no safety data existing neonates and children. Ceftazidime-avibactam has activity against Gram-negative producing Klebsiella pneumoniae carbapenemase, but virtually exist on its use in neonatal pediatric patients.We present single-center case series children <5 years treated ceftazidime-avibactam XDR...
Abstract Candida auris is an emerging fungal pathogen associated with multi-drug resistance rates and widespread outbreaks in hospitals healthcare units worldwide. Sequencing studies have revealed that different clonal lineages of the fungus seem to be prevalent among distinct geographical sites. The first case C. Northern Greece was reported Thessaloniki October 2022, almost 2 years after isolation (Athens 2019). Mycology Laboratory Medical School Aristotle University stands as reference...
Abstract Background Human Metapneumovirus (hMPV) is a recently described respiratory tract virus with significant morbidity among children of younger age. The widespread molecular diagnostic testing has identified hMPV as an important pathogen the upper and lower even in adults, especially older immunosuppressed. aim this study was to identify patients hospitalized infection describe their characteristics. Methods Rhinopharyngeal samples admitted years 2021-22, 2022-23 2023-24 from October...
Abstract Respiratory syncytial virus (RSV) is the most common viral pathogen causing respiratory disease in pediatric population. An unexpected sudden upsurge of RSV infections among children was observed September 2021 Greece. Forty‐one rhinopharyngeal samples from under age 2 years with confirmed bronchiolitis were tested to identify genotype(s) strain(s). The hospitalized during September−November three tertiary hospitals northern A one‐step RT‐PCR which amplifies a fragment second...
Background: Multi/extensively drug-resistant bacterial infections have recently increased and new antimicrobial options are needed for difficult-to-treat infections. Ceftazidime/avibactam (CZA) has been approved patients 3 months to 18 years of age, but real-life data on its off-label use in neonates young infants still scarce. Materials: We report demographic, clinical microbiologic as well outcome safety all cases treated with CZA between January 1, 2021 September 30, 2022 a tertiary...
Abstract The spread of multi-drug resistant (MDR) Gram-negative bacteria, including Klebsiella pneumoniae, constitutes a global threat. most frequent mechanism acquired carbapenem resistance is the production carbapenemases, especially KPC, NDM, VIM, IMP and OXA-48. We analyzed epidemiological trend genes carbapenem-resistant K. pneumoniae (CRKP) strains isolated from critically ill patients in Greek tertiary hospital. study included 150 CRKP isolates collected 116 (77.4%) hospitalized adult...
Background: Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a serious public health issue. Aim of the study was to identify antimicrobial resistance and accessory genes, clonal relatedness evolution dynamics selected CRKP isolates recovered in an adult pediatric intensive care unit tertiary hospital Greece. Methods: Twenty-four during 2018-2022 were included study. Next-generation sequencing performed using Ion Torrent PGM Platform. The identification plasmid content, MLST as well...
Background: Although ceftazidime/avibactam (CAZ/AVI) has become an important option for treating adults and children, no data or recommendations exist neonates. We report a neonatal sepsis case due to CAZ/AVI-resistant blaKPC-2-harboring Klebsiella pneumoniae carrying blaVEB-25 the use of customized active surveillance program in conjunction with enhanced infection control measures. Methods: The index was extremely premature neonate hospitalized 110 days that had been previously treated...
Buckground: Although ceftazidime/avibactam (CAZ/AVI) has become important option for treating adults and children, no recommendations exist neonates. We report a neonatal sepsis case due to CAZ/AVI-resistant KPC-2 producing-Klebsiella pneumoniae carrying blaVEB-25 the use of customized active surveillance program in conjunction infection control measures. Methods: The index was an extremely premature neonate hospitalized 110 days that had been previously treated with multiple antibiotics....
Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a serious public health issue. The study aimed to identify the antimicrobial resistance and accessory genes, clonal relatedness, evolutionary dynamics of selected CRKP isolates recovered in an adult pediatric intensive care unit tertiary hospital Greece.Twenty-four during 2018-2022 were included study. Next-generation sequencing was performed using Ion Torrent PGM Platform. identification plasmid content, MLST, as well comparison multiple...
We report the rare case of Parvimonas micra bacteraemia and secondary spondylodiscitis probably triggered by tooth injury in a rheumatoid arthritis patient.Anaerobic bacteria associated may evade diagnosis due to atypical clinical presentation usually lacking fever, difficulties related microbiological characterisation pathogen.Even though anaerobic spinal infections constitute <3% total, suspicion should remain high, especially positive history for pre-existing oral cavity or...
Clostridioides difficile infection (CDI) has evolved to be the most significant cause of healthcare-associated diarrhoea and one leading representatives infections, with a high associated mortality. The aim this retrospective study was record incidence rates epidemiological clinical features CDI in large tertiary hospital northern Greece years 2022-2023. All patients CDI-compatible symptomatology positive diagnostic test (GDH—glutamate dehydrogenase toxin-positive FIA—Fluorescent...
Antibiotic exposure may convert gut microbiome to reservoir of resistant organisms, including carbapenem-resistant Gram-negative bacteria (CRGNB). Little is known about natural history spontaneous CRGNB decolonization neonates/children and their risk develop infections.Patients hospitalized in a tertiary care hospital (1 days 16 years) found be colonized weekly surveillance cultures during hospitalization (January 2018 December 2019) were prospectively followed after discharge with monthly...
Abstract Objectives Several recent studies highlight the high prevalence of resistance to multiple antibiotic classes used in current treatment regimens for neonatal sepsis and new options are urgently needed. We aimed identify potential combination by investigating drug-resistance genetic profiles most frequently isolated Gram-negative bacteria causing low- middle-income countries (LMICs) NeoOBS study. Material methods from neonates with culture-confirmed 13 clinical sites nine countries,...