A5046552240- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Respiratory viral infections research
- Global Maternal and Child Health
- Virology and Viral Diseases
- Tracheal and airway disorders
- Maternal and Neonatal Healthcare
- Parvovirus B19 Infection Studies
- Malaria Research and Control
- Streptococcal Infections and Treatments
- Pneumonia and Respiratory Infections
- Viral gastroenteritis research and epidemiology
- Tuberculosis Research and Epidemiology
- COVID-19 Impact on Reproduction
- Kawasaki Disease and Coronary Complications
- Dermatological and COVID-19 studies
- Airway Management and Intubation Techniques
- Restraint-Related Deaths
- Syphilis Diagnosis and Treatment
- Antimicrobial Resistance in Staphylococcus
- Blood groups and transfusion
- Neonatal and Maternal Infections
- Rabies epidemiology and control
- Otolaryngology and Infectious Diseases
- Congenital Diaphragmatic Hernia Studies
Faculdade de Medicina de Jundiaí
2016-2025
Instituto Butantan
2024
Universidade de São Paulo
2008-2024
Universidade Federal do Rio de Janeiro
2024
AC Camargo Hospital
2019-2021
London School of Hygiene & Tropical Medicine
2021
Fundação de Amparo à Pesquisa do Estado de São Paulo
2021
Morpho (United States)
2021
Vall d'Hebron Hospital Universitari
2021
Royal Society of Medicine
2021
Abstract Congenital Zika syndrome (CZS) causes early brain development impairment by affecting neural progenitor cells (NPCs). Here, we analyze NPCs from three pairs of dizygotic twins discordant for CZS. We compare RNA-Seq the derived CZS-affected and CZS-unaffected twins. Prior to virus (ZIKV) infection CZS babies show a significantly different gene expression signature mTOR Wnt pathway regulators, key neurodevelopmental program. Following ZIKV in vitro infection, affected individuals have...
Dengue fever is the most common infectious disease transmitted by a mosquito and major economic burden in endemic countries. The reported number of dengue cases 2013 evidences disease's disturbing impact on human health Brazil: 950,193 clinical cases, 3,749 with severe manifestations, 201 deaths (data up to July 13, Pan American Health Organization); any four serotypes was etiologic agent different geographical regions. epidemiological surveillance center “Prof. Alexandre vranjac” documented...
Knowledge regarding the risks associated with Zika virus (ZIKV) infections in pregnancy has relied on individual studies relatively small sample sizes and variable risk estimates of adverse outcomes, or surveillance routinely collected data. Using data from Brazilian Cohorts Consortium, this study aims, to estimate outcomes among offspring women RT-PCR-confirmed ZIKV infection during explore heterogeneity between studies.We performed an participant meta-analysis 1548 pregnant 13 studies,...
A rubella serological survey of 476 individuals selected by cluster sampling technique from Caieiras, a small town located in the outskirts São Paulo city, southeastern Brazil, was carried out over period November 1990-January 1991. The aim study to characterize epidemiology representative non-immunized community south east Brazil. comprised seroprevalence study, stratified age (0-40 years) and seroconversion vaccine non-infected children below 2 years age. Mathematical techniques were...
to estimate the prevalence of infection by respiratory viruses in pediatric patients with cancer and acute (ARI) and/or fever.cross-sectional study, from January 2011 December 2012. The secretions nasopharyngeal aspirates were analyzed children younger than 21 years infections. Patients treated at Grupo em Defesa da Criança Com Câncer (Grendacc) University Hospital (HU), Jundiaí, SP. rapid test was used for detection influenza virus (Kit Biotrin, Inc. Ireland), real-time multiplex polymerase...
In 1992 a major vaccination strategy against measles-mumps-rubella was introduced in the State of Sāo, Brazil. This based on mathematical models and comprised pulse covering aII children aged 1–10 years, followed by inclusion this vaccine routine calendar at 15 months age. The present work reports evaluation efficacy mixed strategy. A rubella seroprevalence survey carried out immediately one year after campaign, comprising 4953 1–15 years. We show that average increased from 0.40 to 0.97...
The purpose of this study was to identify the rate infections due RSV and other viruses in children. In addition we have analyzed demographic data clinical characteristics RSV-positive patients comparing with infected by respiratory viruses. We also described seasonality occurrence a hospital São Paulo. Children below 5 years old admitted Santa Casa de Paulo Hospital between February 2005 September 2006 acute (ARI) were included. A nasopharyngeal specimens obtained sterile No. French feeding...
Abstract Robust epidemiological and biological evidence supports a causal link between prenatal Zika Virus (ZIKV) infection congenital brain abnormalities including microcephaly. However, it remains uncertain if ZIKV in pregnancy also increases the risk for other adverse fetal birth outcomes. In prospective cohort study we investigated influence of on prevalence prematurity, low weight, small-for-gestational-age, death as well microcephaly (i.e., overall disproportionate) offspring women...
A microcefalia é caracterizada, no recém-nascido, por perímetro cefálico inferior a 2 desvios padrão abaixo da média, considerando idade gestacional, sexo e população. Possui causas multifatoriais complexas, afetando o sistema nervoso do feto, ou tardiamente, repercutindo desenvolvimento adaptação criança ao ambiente. Não existe tratamento específico. O Objetivo desta revisão integrativa foi levantar, analisar sintetizar as evidências disponíveis sobre os recursos terapêuticos não...
<title>Abstract</title> In 2015, the Zika virus (ZIKV) outbreak in Brazil caught attention of global community, as public health emergency. ZIKV, an <italic>Orthoflavivirus</italic>transmitted by <italic>Aedes</italic> mosquitoes, initially identified 1947, has evolved from a historically inconspicuous pathogen to significant concern. Beyond mild symptoms resembling Dengue fever, severe conditions such microcephaly and Guillain-Barré syndrome have been linked ZIKV. regions already burdened...
Objetivo: Analisar a contribuição das ações internas de educação continuada na disseminação do conhecimento referente à atual pandemia Coronavírus aos profissionais enfermagem trabalhadores no Hospital Universitário da Faculdade Medicina Jundiaí e como essas podem ser aplicadas para melhor preparo dos controle futuras pandemias. Métodos: Estudo transversal prevalência realizado por meio questionário fechado aplicado 80 Jundiaí. Resultados: O obtido sobre COVID-19 foi considerado adequado com...
Congenital Zika virus (ZIKV) infection may present with a broad spectrum of clinical manifestations. Some sequelae, particularly neurodevelopmental problems, have later onset. We conducted prospective cohort study 799 high-risk pregnant women who were followed up until delivery. Eighty-three and/or newborns considered ZIKV exposed infected. Laboratory diagnosis was made by polymerase chain reaction in the mothers and their respective newborns, as well Dengue virus, Chikungunya serology....
Human parainfluenza viruses account for a significant proportion of lower respiratory tract infections in children. To assess the prevalence as cause acute infection and to compare clinical data this against those human syncytial virus. A prospective study children younger than five years with was conducted. Detection nasopharyngeal aspirate samples performed using indirect immunofluorescence reaction. Length hospital stay, age, history physical exam, diagnoses, evolution (admission...
Zika virus (ZIKV) is highly neurotropic after crossing the placenta, inducing teratogenic effects that result in delayed development and microcephaly infants. The available evidence for vertical transmission of this infection based on placental studies showing alterations trophoblastic tissue. However, complete characterization ZIKV-infected placenta involved pathways has yet to be fully clarified. This case report ZIKV describes morphologic molecular changes placenta. Hyperplasia Hofbauer...
Despite great advances in our knowledge of the consequences Zika virus to human health, many questions remain unanswered, and results are often inconsistent. The small sample size individual studies has limited inference about spectrum congenital manifestations prognosis affected children. Brazilian Cohorts Consortium addresses these limitations by bringing together harmonizing epidemiological data from a series prospective cohort pregnant women with rash children microcephaly and/or other...
The sensitivity and specificity of salivary rubella antibody detection was investigated using samples collected from 301 children after a mass vaccination campaign in the state São Paulo, Brazil. Saliva were by 2 different methods: directly dribbling into container or commercial collecting device. Corresponding finger-prick blood on filter paper. Rubella specific immunoglobulin G (IgG) measured saliva capture radioimmunoassay indirect enzyme-linked immunosorbent assay. IgG showed good...
OBJETIVO: Determinar a prevalência de obesidade acordo com o nível socioeconômico e sexo, em escolares do ensino fundamental, segundo dois critérios diagnósticos. MÉTODOS: Realizou-se um estudo transversal nas escolas públicas fundamental Jundiaí, São Paulo, 662 alunos quinta oitava séries, idades entre dez 18 anos, 2005. A amostra foi selecionada por meio procedimento sistemático, série sexo. Calculou-se índice massa corpórea (IMC). Os pontos corte para classificação estado nutricional...
RESUMO Objetivo: Avaliar o nível de conhecimento do cuidador em relação aos sinais e sintomas respiratórios Infecções Respiratórias Agudas (IRA) a percepção dos mesmos às crianças que necessitam assistência médica. Métodos: Estudo prospectivo transversal, no qual um questionário padronizado com itens relacionados à da gravidade IRA foi administrado cuidadores pacientes pediátricos admitidos serviço emergência hospital universitário período agosto 2011 maio 2012. A análise estatística...
ObjectivesTo describe the clinical presentation, management, and outcomes of Kawasaki disease (KD) in Latin America to evaluate early prognostic indicators coronary artery aneurysm (CAA).Study designAn observational KD registry-based study was conducted 64 participating pediatric centers across 19 American countries retrospectively between January 1, 2009, December 31, 2013, prospectively from June 2014, May 2017. Demographic initial laboratory data were collected. Logistic regression...