A5081969272- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- SARS-CoV-2 and COVID-19 Research
- HIV Research and Treatment
- COVID-19 Clinical Research Studies
- Respiratory viral infections research
- Mosquito-borne diseases and control
- SARS-CoV-2 detection and testing
- Long-Term Effects of COVID-19
- Viral Infections and Vectors
- Retinal and Optic Conditions
- Kawasaki Disease and Coronary Complications
- Neonatal Respiratory Health Research
- COVID-19 Impact on Reproduction
- Congenital Diaphragmatic Hernia Studies
- Pneumonia and Respiratory Infections
- HIV-related health complications and treatments
- Diabetes Management and Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Maternal and Neonatal Healthcare
- Parasitic infections in humans and animals
- Biosensors and Analytical Detection
- Virology and Viral Diseases
- Vaccine Coverage and Hesitancy
- Bacterial Infections and Vaccines
Beneficência Portuguesa de São Paulo
2024-2025
Hospital São Paulo
2007-2025
Faculdade de Ciências Médicas da Santa Casa de São Paulo
2009-2025
Hospital Infantil Albert Sabin
2022-2024
Santa Casa Hospital
2007-2020
Universidade de São Paulo
2020
Irmandade da Santa Casa de Misericórdia de São Paulo
2008-2020
Santa Casa de Misericórdia de Marília
2020
Weatherford College
2020
Pediatric Infectious Diseases Society
2014
Brazil implemented routine immunization with the human rotavirus vaccine, Rotarix, in 2006 and vaccination coverage reached 81% 2008 São Paulo. Our aim was to assess impact of on incidence severe acute gastroenteritis (AGE).We performed a 5-year (2004-2008) prospective surveillance at sentinel hospital Paulo, testing for all children less than 5 years age hospitalized AGE. Genotypes positive samples were determined by reverse transcription polymerase chain reaction.During study, 655 AGE...
Importance Multiple SARS-CoV-2 variants have emerged over the COVID-19 pandemic. The implications for severity in children worldwide are unclear. Objective To determine whether dominant circulating of concern (VOCs) were associated with differences among hospitalized children. Design, Setting, and Participants Clinical data from adolescents (younger than 18 years) who positive obtained 9 countries (Australia, Brazil, Italy, Portugal, South Africa, Switzerland, Thailand, UK, US) during 3...
Abstract Background Brazil became the epicenter of COVID-19 pandemic in Latin America since May 2020, reporting highest number cases and deaths region. Healthcare workers (HCWs) are at increased risk SARS-CoV-2 infection, experiencing a significant burden from COVID-19. Identifying understanding clinical characteristics factors associated with infection paramount importance to inform screening strategies control practices this scenario. The aims study were investigate prevalence HCWs...
Likely as in other viral respiratory diseases, SARS-CoV-2 elicit a local immune response, which includes production and releasing of both cytokines secretory immunoglobulin (SIgA). Therefore, this study, we investigated the levels specific-SIgA for airways mucosa 37 patients who were suspected COVID-19. According to RT-PCR results, separated into three groups: negative COVID-19 viruses (NEGS, n = 5); but positive presence (OTHERS, (COVID-19, 27). Higher SARS-CoV-2, IFN-β, IFN-γ found group...
Transmitted drug resistance mutations (TDRM) have been a constant threat to treatment efficacy. We evaluated TDRM in plasma RNA of 217 antiretroviral therapy-naive patients from sites the São Paulo metropolitan area, collected 2012 2014. The partial HIV-1 polymerase region was sequenced using Big Dye terminators at an ABI 3130 Genetic Analyzer. defined according Stanford database calibrated population (CPR v.6.0), but other (DRM) considered IAS list (IAS, 2014) and HIV Database Genotyping...
A case of a 37-week pregnant woman who developed hemorrhagic syndrome and acute renal failure after contact with Lonomia caterpillars is reported. The accident also initiated labour the patient gave birth to an alive child. Some pathophysiological aspects genital bleeding are discussed.
HIV drug resistance genotype testing, performed on 39 HIV-infected treatment-naive children from 2000 to 2011, identified 5 (12.8%) with mutations: 5.3% nucleoside reverse transcriptase inhibitors, nonnucleoside inhibitors and 7.7% protease inhibitors. There was a trend for increasing prevalence of mutations during the 11-year study period.
There is a massive demand to identify alternative methods detect new cases of COVID-19 as well investigate the epidemiology disease. In many countries, importation commercial kits poses significant impact on their testing capacity and increases costs for public health system. We have developed an ELISA IgG antibodies against SARS-CoV-2 using recombinant viral nucleocapsid (rN) protein expressed in E. coli. Using total 894 clinical samples we showed that rN-ELISA was able with high...
In 2020, Brazil became the epicentre of coronavirus disease (COVID-19) pandemic in Latin America, resulting an unparalleled health catastrophe. Nevertheless, comprehensive clinical reports Brazilian children are not available.This retrospective, hospital-based, active surveillance study was performed to identify paediatric patients with COVID-19 who presented at a private academic medical centre large urban area between March 2020 and 2021. Clinical demographic information analysed for those...
Household contacts are important sources of Bordetella pertussis in infants. A total 353 household 97 index cases were evaluated for by culture and polymerase chain reaction. Twenty eight positive (8.0%). The presence symptoms did not influence the rate diagnosed bacteriologic communicants. We conclude that with an case can be B. independently symptoms.
Over the last 3 decades since first AIDS cases appeared, we have witnessed great progress in therapeutic methodologies that transformed evolution of disease from debilitating and fatal, into chronic controllable. HIV-infected children are arriving at adolescence bringing specific challenges, not only to themselves, but also their families caregivers. This retrospective study sets forth epidemiological treatment characteristics 46 adolescents followed a specialized university service relating...
Management of children with HIV/AIDS is specially challenging. Age-related issues do not allow for direct transposition adult observations to this population. CXCR4 tropism has been associated disease progression in adults. The geno2pheno web-base a friendly tool predict viral on envelope V3 sequences, generating false positive rate prediction. We evaluated the association HIV-1 prediction clinical and laboratory outcome 73 São Paulo, Brazil. was strongly lower (nadir) CD4 documented during...