A5015080960- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Influenza Virus Research Studies
- Immune responses and vaccinations
- Viral Infections and Vectors
- SARS-CoV-2 detection and testing
- Respiratory viral infections research
- Neonatal Respiratory Health Research
- Kawasaki Disease and Coronary Complications
- Cancer Immunotherapy and Biomarkers
- Pediatric health and respiratory diseases
- Animal Disease Management and Epidemiology
- Long-Term Effects of COVID-19
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Vector-borne infectious diseases
- Advanced Chemical Sensor Technologies
- Diabetes and associated disorders
- Telomeres, Telomerase, and Senescence
- Olfactory and Sensory Function Studies
- COVID-19 epidemiological studies
- Parasites and Host Interactions
- Vector-Borne Animal Diseases
Emory University
2022-2025
University of Colorado Denver
2025
Children's Hospital Colorado
2025
University of Colorado Anschutz Medical Campus
2025
Pontificia Universidad Católica de Chile
2018-2024
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2019-2024
Fundació Clínic per a la Recerca Biomèdica
2023
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2021-2022
Complejo Asistencial Sótero del Río
2021
Hospital General Universitario de Alicante Doctor Balmis
2021
The Omicron variant of SARS-CoV-2 has been shown to evade neutralizing antibodies elicited by vaccination or infection. Despite the global spread variant, even among highly vaccinated populations, death rates have not increased concomitantly. These data suggest that immune mechanisms beyond antibody-mediated virus neutralization may protect against severe disease. In addition pathogens, contribute control and clearance infections through Fc effector mechanisms. Here, we probed ability...
A major challenge of the SARS-CoV-2 pandemic is to better define "protective thresholds" guide global response. We aimed characterize longitudinal dynamics antibody responses in naturally infected individuals Chile and compared them humoral induced after immunization with CoronaVac-based on an inactivated whole virus -or BNT162b2- based mRNA-vaccines. also contrasted respective effectiveness efficacy data available for both vaccines.
Abstract Since the emergence of SARS-CoV-2, vaccines targeting COVID-19 have been developed with unprecedented speed and efficiency. CoronaVac, utilising an inactivated form virus mRNA26 based Pfizer/BNT162b2 are widely distributed. Beyond ability to induce production neutralizing antibodies, they might lead generation antibodies attenuating disease by recruiting cytotoxic opsonophagocytic functions. However, Fc-effector functions vaccine induced much less studied than neutralization. Here,...
This study characterizes, biologically and clinically, a novel type of dendritic cells (DC) produced in the short term called tumor antigen-presenting (TAPCells). In particular, we identified factors present lysate derived from heat-shocked allogeneic melanoma (TRIMEL) that are associated with TAPCells' enhanced capability to induce CD8(+) T-cell responses vitro vaccinated patients.First, extensive phenotypic functional characterization TAPCells was performed, followed by vaccination 45...
ABSTRACT The durability of circulating neutralizing antibody (nAb) responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and their boosting by vaccination remains be defined. We show that outpatient hospitalized SARS-CoV-2 seropositive individuals mount a robust response peaks at days 23 27 post-symptom onset, respectively. Although nAb titers remained higher in patients, both study groups showed long-lasting can persist for up 12 months after natural infection....
Objective: Mycoplasma pneumoniae (Mp) is the most detected bacterial pathogen in children with community-acquired pneumonia (CAP). Our primary objective was to compare clinical presentation, management, and outcomes of without Mp CAP across 6 children’s hospitals. Methods: Eligible were 2 months old or above diagnosed a prospective multicenter cohort study between October 1, 2015 June 31, 2018. Children excluded if they had complex chronic conditions. tested for via polymerase chain reaction...
<title>Abstract</title> Immunotherapeutic approaches to eliminate latently HIV-infected cells are focused on the adaptive immune system. Herein we provide mechanistic evidence for a molecular cascade characterized by epigenetic reprogramming of innate myeloid and CD4 T cells. The coordinate regulation gene expression mediated transcription factors (TFs) IRF3, IRF7, STAT1 C/EBPβ versus AP-1, promoted development antiviral immunity in these which was associated with control viral load decay...
Chronic Obstructive Pulmonary Disease (COPD) is associated with an abnormal pulmonary and systemic immune response to tobacco smoking. Yet, how do cells relate within between these two biological compartments, the infiltrate influences lung transcriptome, what role of active smoking vs. presence disease unclear. To investigate questions, we simultaneously collected tissue blood from 65 individuals stratified by habit disease. The cell composition both tissues was assessed flow cytometry,...
T he pandemic caused by a novel severe acute respi- ratory syndrome coronavirus 2 (SARS-CoV-2) can cause several gastrointestinal (GI) symptoms.A recent systematic review showed prevalence of GI symptoms in 17.6%.The most frequent manifestations were anorexia (26.8%), diarrhea (12.5%), nausea/vomiting (10.2%), and abdominal pain (9.2%), 1 reports the detection viral RNA stools for prolonged periods (70.3%). We established frequency impact symptoms, presence among Chilean patients infected...
Despite the dramatic spread of Omicron globally, even among highly vaccinated populations, death rates have not increased concomitantly. These data argue that alternative immune mechanisms, beyond neutralization, may continue to confer protection against severe disease. Beyond their ability bind and block infection, antibodies contribute control clearance multiple infections via direct antiviral immunity Fc-effector mechanisms. Thus, here we probed vaccine induced antibodies, across three...
ABSTRACT Novel H1N2 and H3N2 swine influenza A viruses (IAVs) have recently been identified in Chile. The objective of this study was to evaluate their zoonotic potential. We perform phylogenetic analyses determine the genetic origin evolution these viruses, a serological analysis level cross-protective antibodies human population. Eight genotypes were identified, all with pandemic H1N1 2009-like internal genes. subtypes more commonly detected. Swine IAVs had hemagglutinin neuraminidase...
Although vaccines have reduced the burden of COVID-19, their efficacy in helminth infection–endemic areas is not well characterized. We evaluated impact infection by Heligmosomoides polygyrus bakeri (Hpb), a murine intestinal roundworm, on an mRNA vaccine targeting Wuhan-1 spike protein severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mice. immunization generated similar B cell responses Hpb-infected and uninfected mice, polyfunctional CD4 + CD8 T were markedly mRNA-vaccinated...
Tobacco smoking is the main environmental risk factor for chronic obstructive pulmonary disease (COPD), but not all smokers develop disease. A population of lung-resident mesenchymal stem cells (LR-MSCs) exist in healthy lungs, how tobacco affects them and their role COPD have been assessed yet. Using a sphere-based culture technique, we isolated LR-MSCs from lung tissue obtained nonsmokers current former with without (n = 53). The were characterized by flow cytometry Affymetrix arrays....
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Although vaccines have reduced COVID-19 disease burden, their efficacy in helminth infection endemic areas is not well characterized. We evaluated the impact of by
// Tamara García-Salum 1, 2 , Andrea Villablanca Franziska Matthäus 3 Andrés Tittarelli Mauricio Baeza 4 Cristián Pereda M. Alejandra Gleisner Fermín E. González 2, 5 Mercedes N. López Jörg D. Hoheisel 6 Johannes Norgauer 7 Peter J. Gebicke-Haerter 8 and Flavio Salazar-Onfray 1 Disciplinary Program of Immunology, Institute Biomedical Sciences, Faculty Medicine, Universidad de Chile, 8380453 Santiago, Chile Millennium on Immunology Immunotherapy, Biological Sciences FIAS, University...
Accelerated ageing is implicated in the pathogenesis of respiratory diseases as chronic obstructive pulmonary disease (COPD), but recent evidence indicates that COPD can have roots early life. Here we hypothesise accelerated markers might a role pathobiology young COPD. The objective this study was to compare two hallmarks ageing, telomere length (TL), and mitochondrial DNA copy number (mtDNA-CN, surrogate marker dysfunction) (≤ 50 years) old (&gt;50 smokers, with without Both, TL...
Autologous dendritic cells (DCs) loaded with cancer cell-derived lysates have become a promising tool in immunotherapy. During the last decade, we demonstrated that vaccination of advanced melanoma patients autologous tumor antigen presenting (TAPCells) an allogeneic heat shock- (HS-) conditioned lysate (called TRIMEL) is able to induce antitumor immune response associated prolonged patient survival. TRIMEL provides not only broad spectrum potential melanoma-associated antigens but also...