Louise Sigfrid
A5050637515- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- COVID-19 and Mental Health
- Intensive Care Unit Cognitive Disorders
- Viral Infections and Outbreaks Research
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and healthcare impacts
- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Disaster Response and Management
- Clinical practice guidelines implementation
- Primary Care and Health Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Zoonotic diseases and public health
- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Health Policy Implementation Science
- COVID-19 epidemiological studies
- Frailty in Older Adults
- Global Health and Surgery
- Delphi Technique in Research
- Kawasaki Disease and Coronary Complications
- Psychosomatic Disorders and Their Treatments
- Health and Medical Research Impacts
- HIV/AIDS Research and Interventions
University of Oxford
2016-2025
University of London
2024
London School of Hygiene & Tropical Medicine
2024
Tulane University
2024
University of Leicester
2021-2023
University Hospitals of Leicester NHS Trust
2023
NIHR Leicester Biomedical Research Centre
2021-2023
Glenfield Hospital
2023
European University Institute
2023
St Mary's Hospital
2023
Abstract Objective To characterise the clinical features of patients admitted to hospital with coronavirus disease 2019 (covid-19) in United Kingdom during growth phase first wave this outbreak who were enrolled International Severe Acute Respiratory and emerging Infections Consortium (ISARIC) World Health Organization (WHO) Clinical Characterisation Protocol UK (CCP-UK) study, explore risk factors associated mortality hospital. Design Prospective observational cohort study rapid data...
Abstract Objective To characterise the clinical features of children and young people admitted to hospital with laboratory confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in UK explore factors associated admission critical care, mortality, development multisystem inflammatory adolescents temporarily related disease 2019 (covid-19) (MIS-C). Design Prospective observational cohort study rapid data gathering near real time analysis. Setting 260 hospitals...
Structured abstract Objective To characterize the clinical features of patients with severe COVID-19 in UK. Design Prospective observational cohort study rapid data gathering and near real-time analysis, using a pre-approved questionnaire adopted by WHO. Setting 166 UK hospitals between 6 th February 18 April 2020. Participants 16,749 people COVID-19. Interventions No interventions were performed, but consent samples taken for research purposes. Many participants co-enrolled other...
The long-term sequelae of coronavirus disease 2019 (COVID-19) in children remain poorly characterised. This study aimed to assess outcomes previously hospitalised with COVID-19 and associated risk factors.This is a prospective cohort (≤18 years old) admitted hospital confirmed COVID-19. Children between 2 April 2020 26 August were included. Telephone interviews used the International Severe Acute Respiratory Emerging Infection Consortium (ISARIC) Health Wellbeing Follow-up Survey for...
While it is now widely accepted that host inflammatory responses contribute to lung injury, the pathways drive severity and distinguish coronavirus disease 2019 (COVID-19) from other viral diseases remain poorly characterized. We analyzed plasma samples 471 hospitalized patients recruited through prospective multicenter ISARIC4C study 39 outpatients with mild disease, enabling extensive characterization of across a full spectrum COVID-19 severity. Progressive elevation levels numerous...
The long-term sequalae of COVID-19 remain poorly characterized. We assessed persistent symptoms in previously hospitalized patients with and potential risk factors.
Studies of patients admitted to hospital with COVID-19 have found varying mortality outcomes associated underlying respiratory conditions and inhaled corticosteroid use. Using data from a national, multicentre, prospective cohort, we aimed characterise people disease, assess the level care received, measure in-hospital mortality, examine effect use.We analysed International Severe Acute Respiratory emerging Infection Consortium (ISARIC) WHO Clinical Characterisation Protocol UK (CCP-UK)...
BackgroundCOVID-19 is a multisystem disease and patients who survive might have in-hospital complications. These complications are likely to important short-term long-term consequences for patients, health-care utilisation, system preparedness, society amidst the ongoing COVID-19 pandemic. Our aim was characterise extent effect of complications, particularly in those survive, using International Severe Acute Respiratory Emerging Infections Consortium WHO Clinical Characterisation Protocol...
A substantial portion of people with COVID-19 subsequently experience lasting symptoms including fatigue, shortness breath, and neurological complaints such as cognitive dysfunction many months after acute infection. Emerging evidence suggests that this condition, commonly referred to long COVID but also known post-acute sequelae SARS-CoV-2 infection (PASC) or post-COVID-19 could become a significant global health burden.While the number studies investigating condition is increasing, there...
Previous studies assessing the prevalence of COVID-19 sequelae in adults and children were performed absence an agreed definition. We investigated post-COVID-19 condition (PCC) (WHO definition), at 6- 12-months follow-up, amongst previously hospitalised assessed risk factors.Prospective cohort study with confirmed Moscow, between April August, 2020. Two follow-up telephone interviews, using International Severe Acute Respiratory Emerging Infection Consortium survey, 6 12 months after...
Post COVID-19 condition (PCC), as defined by WHO, refers to a wide range of new, returning, or ongoing health problems in people who have had COVID-19, and it represents rapidly emerging public priority. We aimed establish how this developing has affected patients South Africa which population groups are at risk.
Abstract Background We describe demographic features, treatments and clinical outcomes in the International Severe Acute Respiratory emerging Infection Consortium (ISARIC) COVID-19 cohort, one of world's largest international, standardized data sets concerning hospitalized patients. Methods The set analysed includes patients between January 2020 2022 52 countries. investigated how symptoms on admission, co-morbidities, risk factors varied by age, sex other characteristics. used Cox...
The coronavirus disease 2019 (COVID-19) pandemic substantially impacted different age groups, with children and young people not exempted. Many have experienced enduring health consequences. Presently, there is no consensus on the outcomes to assess in post-COVID-19 condition. Furthermore, it unclear which measurement instruments are appropriate for use research clinical management of post-COVID-19. To address these unmet needs, we conducted a study, aiming develop core outcome set (COS) an...