A5102967268- Long-Term Effects of COVID-19
- Infective Endocarditis Diagnosis and Management
- COVID-19 and Mental Health
- Antibiotics Pharmacokinetics and Efficacy
- COVID-19 and healthcare impacts
- Central Venous Catheters and Hemodialysis
- Antimicrobial Resistance in Staphylococcus
- Intensive Care Unit Cognitive Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Surgical site infection prevention
- Orthopedic Infections and Treatments
- COVID-19 Clinical Research Studies
- Antibiotic Resistance in Bacteria
- Bacterial Identification and Susceptibility Testing
- Antibiotic Use and Resistance
- Childhood Cancer Survivors' Quality of Life
- Nosocomial Infections in ICU
- Cardiac Valve Diseases and Treatments
- Surgical Sutures and Adhesives
- Sepsis Diagnosis and Treatment
- Streptococcal Infections and Treatments
- Urinary Tract Infections Management
- Acute Lymphoblastic Leukemia research
- IL-33, ST2, and ILC Pathways
- Pneumonia and Respiratory Infections
University Hospitals Birmingham NHS Foundation Trust
2008-2024
University of Birmingham
2024
Queen Elizabeth Hospital
2024
Mater Misericordiae University Hospital
2023
University College Dublin
2023
Brighton and Sussex Medical School
2021-2022
University of Brighton
2021
Queen Elizabeth Hospital Birmingham
2019
Queen Elizabeth Hospital
2005-2016
Mater Hospital
2014
ABSTRACT Carbapenem-resistant Pseudomonas aeruginosa and Acinetobacter spp. represent major threats have few approved therapeutic options. Non-fermenting Gram-negative isolates were collected from hospitalized inpatients 49 sites in 6 European countries between 01 January 2020 31 December underwent susceptibility testing against cefiderocol β-lactam/β-lactamase inhibitor combinations. Meropenem-resistant (MIC >8 mg/L), cefiderocol-susceptible analyzed by PCR, cefiderocol-resistant...
ABSTRACT Carbapenem-resistant Enterobacterales represent a major health threat and have few approved therapeutic options. isolates were collected from hospitalized inpatients 49 sites in six European countries (1 January–31 December 2020) underwent susceptibility testing to cefiderocol β-lactam/β-lactamase inhibitor combinations. Meropenem-resistant (MIC >8 mg/L) cefiderocol-susceptible analyzed by PCR, cefiderocol-resistant whole-genome sequencing, identify resistance mechanisms....
Abstract Evidence before this study It is emerging that long-term symptoms are often present in people who have had acute COVID-19 disease. These affect a range of organ systems including respiratory, cardiovascular and neurological systems. not clear how many patients required hospitalisation develop these the impact they on quality life. We searched PubMed 24 th March 2021 using terms ‘COVID-19’, ‘long-Covid’, ‘long-term’ ‘outcomes’. This was supplemented by hand searching relevant...
The diagnosis of prosthetic joint infection and its differentiation from aseptic loosening remains problematic. definitive laboratory diagnostic test is the recovery identical infectious agents multiple intraoperative tissue samples; however, interpretation positive cultures often complex as frequently associated with low numbers commensal microorganisms, in particular coagulase-negative staphylococci (CNS). In this investigation, value serum procalcitonin (PCT), interleukin-6 (IL-6) soluble...
Paediatric cancer is a leading cause of death for children. Children in low-income and middle-income countries (LMICs) were four times more likely to die than children high-income (HICs). This study aimed test the hypothesis that COVID-19 pandemic had affected delivery healthcare services worldwide, exacerbated disparity paediatric outcomes between LMICs HICs.A multicentre, international, collaborative cohort study.91 hospitals centres 39 providing treatment patients March December...
Central venous catheters (CVCs) are commonly secured with sutures which associated microbial colonization and infection. We report a comparison of suture-free system standard for securing short-term CVC in an international multicentre, prospective, randomized, non-blinded, observational feasibility study. Consented critical care patients who had inserted as part their clinical management were randomized to receive either or the secure CVC. The main outcome measures migration (daily...
Antimicrobial catheters have been utilized to reduce risk of catheter colonization and infection. We aimed determine if there is a greater than expected microorganism-specific associated with the use antimicrobial central venous (CVCs).We performed meta-analysis 21 randomized, controlled trials comparing incidence specific bacterial fungal species colonizing CVCs standard in hospitalized patients.The proportion all colonized minocycline-rifampin found harbor Candida was Candida. In...
Numerous guidelines have been published by consensus groups worldwide regarding optimal skin antisepsis prior to surgical incision or insertion of intravascular catheters [1Loveday H.P. Wilson J.A. Pratt R.J. Golsorkhi M. Tingle A. Bak et al.epic3: National evidence-based for preventing healthcare-associated infections in NHS hospitals England.J Hosp Infect. 2014; 86: S1-S70Abstract Full Text PDF PubMed Scopus (679) Google Scholar, 2National Institute Health and Care Excellence Surgical site...
Background: The use of mechanical bowel preparation and prophylaxis with oral antimicrobial agents can prevent surgical site infection (SSI) in colorectal procedures, but routine adoption these other practices by surgeons has been limited. aim this study was to determine the actual practice surgeon beliefs about preventative measures elective operations compare them established recommendations. Methods: Web-based survey sent assessing knowledge, beliefs, regarding for SSI. Results: Of 355...
There is paucity of data around the support that medical students have been provided with, need to be and would like with during COVID-19 pandemic. This study sought explore effects pandemic on establish they require.A prospective, observational, multicentre was conducted in 2020. All interim foundation year 1 doctors were eligible participate.Six hundred forty individuals participated from 32 schools. Participants reported a drop their mood following onset (p < 0.001). evident both May...
Introduction Childhood cancers are a leading cause of non-communicable disease deaths for children around the world. The COVID-19 pandemic may have impacted on global children’s cancer services, which can consequences childhood outcomes. Global Health Research Group Children’s Non-Communicable Diseases is currently undertaking first international cohort study to determine variation in paediatric management during pandemic, and short-term medium-term impacts Methods analysis This multicentre,...
Vulnerable patients in an intensive care unit (ICU) setting are at high risk of infection from bacteria including gut-colonising Escherichia coli and Klebsiella species. Complex ICU procedures often depend on successful antimicrobial treatment, underscoring the importance understanding extent patient colonisation by multi-drug-resistant organisms (MDROs) large UK ICUs. Previous work ICUs globally uncovered rates transmission MDROs, but situation is less understood. Here, we investigated...
Abstract Background: Chlorhexidine gluconate (CHG) has been shown to reduce the microbial load at intravascular (IV) catheter insertion sites and risk of catheter-related infections. The Centers for Disease Control Prevention UK National Institute Health Care Excellence subsequently recommended CHG-containing IV dressings specific clinical indications. Aim: To evaluate staff perceptions a standard transparent dressing in comparison incorporating 2% (w/w) CHG gel pad when used site short-term...
<h3>Introduction</h3> FC has previously been shown to be markedly raised in children and adults with IBD its stability allowing the convenient collection of this non-invasive marker both inpatient outpatient settings. <h3>Aims</h3> Firstly evaluate all results performed a regional paediatric hospital analyse patient outcome, for 6 years after test became routinely available our NHS health board on 01/01/05. Secondly, ‘clinical feel’ that cut-off 200 ug/g is warranted as guide likelihood...
<h3>Introduction</h3> The measurement of faecal calprotectin (FC) in patients with suspected bowel inflammation has become routine many centres recent years. Although FC levels have been shown to correspond radio-nucleotide labelled neutrophil scans and endoscopic appearances those inflammatory disease (IBD), it is still unclear as the value inform IBD diagnosis, especially regard investigation. <h3>Methods</h3> records cohort all who were diagnosed (using standard assessment) within...