A5037064887- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Screening and Detection
- Colorectal and Anal Carcinomas
- Colorectal Cancer Treatments and Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Anorectal Disease Treatments and Outcomes
- Neuropeptides and Animal Physiology
- Enhanced Recovery After Surgery
- Surgical site infection prevention
- Gastric Cancer Management and Outcomes
- Gastrointestinal motility and disorders
- Pancreatic and Hepatic Oncology Research
- Diet and metabolism studies
- Regulation of Appetite and Obesity
- Pelvic and Acetabular Injuries
- Pelvic floor disorders treatments
- Urological Disorders and Treatments
- Receptor Mechanisms and Signaling
- Advanced Breast Cancer Therapies
- Ureteral procedures and complications
- Clinical practice guidelines implementation
- Hepatocellular Carcinoma Treatment and Prognosis
- Genetic factors in colorectal cancer
- Helicobacter pylori-related gastroenterology studies
- Reconstructive Surgery and Microvascular Techniques
Duke University
2016-2025
Duke Medical Center
2016-2025
Duke University Hospital
2012-2024
Duke University Health System
2019-2024
University Hospital Southampton NHS Foundation Trust
2024
South University
2024
University of Southampton
2023
Southampton General Hospital
2023
American College of Surgeons
2016-2019
Royal Adelaide Hospital
2019
In vivo somatosensory stimuli evoked the release of substance P from primary afferent neurons that terminate in spinal cord and stimulated endocytosis receptors rat neurons. The distal dendrites showed receptor internalization underwent morphological reorganization, changing a tubular structure to one characterized by swollen varicosities connected thin segments. This dendritic structural reorganization provided specific image activated P. Thus can drive reversible changes central nervous...
BACKGROUND: Enhanced recovery after surgery (ERAS) is a multimodal approach to perioperative care that combines range of interventions enable early mobilization and feeding surgery. We investigated the feasibility, clinical effectiveness, cost savings an ERAS program at major U. S. teaching hospital. METHODS: Data were collected from consecutive patients undergoing open or laparoscopic colorectal during 2 time periods, before implementation protocol. included patient demographics, operative,...
In Brief Objective: To determine the association between preoperative bowel preparation and 30-day outcomes after elective colorectal resection. Methods: Patients from 2012 Colectomy-Targeted American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) database who underwent resection were included for analysis assigned to 1 4 groups based on type they received [combined mechanical oral antibiotic (OAP), only, OAP or no preparation]. The status postoperative was...
Surgical site infections (SSIs) in colorectal surgery are associated with increased morbidity and health care costs.To determine the effect of a preventive SSI bundle (hereafter bundle) on rates costs surgery.Retrospective study institutional clinical cost data. The period was January 1, 2008, to December 31, 2012, outcomes were assessed compared before after implementation July 2011.Academic tertiary referral center among 559 patients who underwent major elective surgery.The primary outcome...
Studies on cultured cells have shown that agonists induce several types of G protein-coupled receptors to undergo internalization. We investigated this phenomenon in rat striatum, using substance P (SP)-induced internalization the SP receptor (SPR) as our model system. Within 1 min a unilateral striatal injection anesthetized rat, nearly 60% SPR-immunoreactive neurons within zone display massive SPR--i.e., 20-200 SPR+ endosomes per cell body. dendrites SPR undergoes striking translocation...
Several lines of evidence indicate that tachykinin neuropeptides [substance P (SP), substance K (SK), and neuromedin (NK)] play a role in regulating the inflammatory immune responses. To test this hypothesis human disease, quantitative receptor autoradiography was used to examine possible abnormalities binding sites surgical specimens from patients with bowel disease. Surgical colon were obtained ulcerative colitis (n = 4) Crohn disease 4). Normal tissue uninvolved areas extensive resections...
Recently, the number of prehabilitation trials has increased significantly. The identification key research priorities is vital in guiding future directions. Thus, aim this collaborative study was to define for patients undergoing cancer surgery.The Delphi methodology implemented over three rounds surveys distributed experts from across multiple specialties, tumour streams and countries via a secure online platform. In first round, participants were asked provide baseline demographics...
Objective To examine clinical outcomes in patients receiving neoadjuvant chemoradiation for locally advanced rectal adenocarcinoma. Summary Background Data Preoperative radiation therapy, either alone or combination with 5-fluorouracil-based chemotherapy, has proven both safe and effective the treatment of cancer. However, data are lacking regarding which subgroups benefit from therapy terms decreased local recurrence increased survival rates. Methods A retrospective chart review was...
Purpose Overexpression of epidermal growth factor receptor (EGFR) has been associated with aggressive tumor phenotypes, chemotherapy, and radiation resistance, as well poor survival in preclinical clinical models. The EGFR inhibitor gefitinib potentiates chemotherapy cytotoxicity models, including pancreatic colorectal cancer. We initiated two phase I trials assessing the combination gefitinib, capecitabine, patients localized rectal Patients Methods pathologically confirmed adenocarcinoma...
Although restraint stress accelerates colonic transit via a central corticotropin-releasing factor (CRF), the precise mechanism still remains unclear. We tested hypothesis that and CRF stimulate motility vagal pathway 5-HT 3 receptors of proximal colon in rats. 51 Cr was injected catheter positioned to measure transit. The rats were subjected for 90 min or received intracisternal injection CRF. Ninety minutes after administration Cr, entire removed, geometric center (GC) calculated. Four...
This study examines short-term outcomes and pathologic surrogates of oncologic results among patients undergoing robotic versus laparoscopic low anterior resection for rectal cancer. A total 6403 met inclusion criteria. Although the approach required significantly fewer conversions to open, proper surgery were nearly identical between 2 approaches.Although (LLAR) has gained popularity as an acceptable approach, (RLAR) remains largely unproven. We compared cancer either RLAR or LLAR.All with...
Abstract We explored plasma and urinary concentrations of two members the vascular endothelial growth factor (VEGF) family their receptors as potential response toxicity biomarkers bevacizumab with neoadjuvant chemoradiation in patients localized rectal cancer. The VEGF, placental (PlGF), soluble VEGF receptor 1 (sVEGFR-1), sVEGFR-2 were measured urine at baseline during treatment. Pretreatment values changes over time analyzed pathological to treatment well for acute locally advanced cancer...
Rectourethral fistulas are an uncommon, yet devastating occurrence after treatment for prostate cancer or trauma, and their surgical management has historically been nonstandardized. Anecdotally, irradiated rectourethral portend a worse prognosis.To review outcomes of in radiated nonirradiated patients to construct logical algorithm.A retrospective was undertaken all presenting Duke University with the diagnosis fistula from 1996 2012.Thirty-seven presented were treated fistulas: 21 received...
A laparoscopic approach has been proposed to reduce the high morbidity and mortality associated with Hartmann procedure for emergency treatment of diverticulitis.The objective our study was determine whether a reduces early or patients undergoing an operation diverticulitis.This is comparative effectiveness study. subset entire American College Surgeons National Surgical Quality Improvement Program patient sample matched on propensity their were used compare postoperative outcomes between...
Preoperative assessment typically equates to evaluating and accepting the presenting condition of patient (unless extreme) commonly occurs only a few days before planned surgery. While this timing enables preoperative history examination mitigates unexpected findings on day surgery that may delay throughput, it does not allow for meaningful management modifiable medical conditions. Evidence is limited regarding how best balance efforts mitigate risk factors versus Furthermore, while concept...
PURPOSE: After resection of the distal rectum with a straight reanastomosis, poor bowel function can occur. This is felt to be because loss rectal reservoir. To overcome this, neoreservoir using colonic J-pouch has been advocated in low colorectal and coloanal anastomosis. However, difficulties reach, inability fit pouch into narrow pelvis, postoperative evacuation problems make problematic. Coloplasty new technique that may seen anastomosis J-pouch. The purpose this study was compare...
Abstract In humans and dogs, it is known that motilin regulates phase III contractions of migrating motor complex (MMC) in the fasted state. rats, however, its receptor have not been found, administration failed to induce any III‐like contractions. Ghrelin was discovered as endogenous ligand for growth hormone secretagogue (GHS‐R) from rat stomach. promotes gastric premature (phase contractions) state rats. We hypothesized ghrelin spontaneous Strain gauge transducer sutured on antrum a...