A stratified organization of visual, somatic and acoustic representations was observed in the cat SC. Cells superficial laminae were exclusively visual. Visual, somatic, cells intermediate while deeper predominantly nonvisual. detailed examination tactile representation revealed a somatotopic plan which register with overlying visuotopy. The magnified central visual fields overlapped face and, as RFS moved temporally, underlying displaced caudal distal. This topographical overlap can be...

Abstract The topographical relations of the visual field with superior colliculus rat was investigated using constant small stimuli and recording electrical response aggregate unit activity fine tip metal microelectrodes. A precise essentially linear projection onto contralateral demonstrated after appropriate corrections for brain curvature were performed. general pattern arrangement retinotopic is similar to that found in infra‐mammalian vertebrates. An ipsilateral appears be absent....

Several lines of evidence indicate that tachykinin neuropeptides [substance P (SP), substance K (SK), and neuromedin (NK)] play a role in regulating the inflammatory immune responses. To test this hypothesis human disease, quantitative receptor autoradiography was used to examine possible abnormalities binding sites surgical specimens from patients with bowel disease. Surgical colon were obtained ulcerative colitis (n = 4) Crohn disease 4). Normal tissue uninvolved areas extensive resections...

Abstract The distribution of calcitonin‐gene‐related peptide‐like immunoreactivity (CGRP‐IR) was studied in sections decalcified rat head and selected whole‐mount preparations order to address the complex peptidergic innervation patterns peripheral cephalic specialized zones examine neuronal ganglia situ. Labeled neuron somata trigeminal, glossopharyngeal, vagal comprised a large proportion small medium size type B ganglion cells. Parasympathetic (ciliary, otic, sphenopalatine,...

Abstract The distribution of calcitonin‐gene‐related peptide (CGRP) immunoreactivity (IR) was studied in peripheral tissues rats. ganglionic origin, somatosensory nature, and anatomic relations this thin‐axon population were evaluated with particular emphasis on possible nociceptive roles. In animals untreated colchicine, CGRP‐IR is found a vast proportion small‐ medium‐diameter sensory ganglion cells that give rise to numerous thinly myelinated unmyelinated axons display throughout the...

Normal and reactive astrocytes in the cerebral cortex of rat have been studied with electron microscope following focal alpha particle irradiation. The presence glycogen approximately 60-A fibrils identify astrocyte cytoplasm formalin-perfused tissue. particles facilitate identification small processes subpial perivascular end-feet. Both protoplasmic fibrous contain cytoplasmic should be distinguished on basis configuration their distribution. Acutely are characterized by a marked increase...

Polyethylene cuffs of varying inner diameters were applied to the rat sciatic or sural nerve with aim inducing a standardized injury, as assessed by morphometric analyses fiber-size spectrum alterations, associated behavioral manifestations neuropathic pain. The temporal sequence axonal degeneration and regeneration was examined in parallel pain initiation recovery over 6-week postoperative (PO) period. Cuffs 0.028–0.030″ diameter loosely enclosed nerves young rats elicited relatively...

As part of a program to explore patterns innervation by nociceptor-related thin sensory axons in variety peripheral regions, we have labeled calcitonin gene-related peptide immunoreactive (CGRP-IR) nerve fibers whole mounts rat testicular tunica vasculosa and cornea. Efforts were undertaken visualize the numerically significant fluoride-resistant acid phosphatase (FRAP)-containing axon population, whose endings heretofore remained undemonstrable due technical limitations currently available...

Abstract High‐threshold mechanoreceptors (mechanical nociceptors) with myelinated axons were electrophysiologically identified in hairy skin of the cat as described by Burgess and Perl ('67). Such elements possess receptive fields consisting a number punctate areas from which maximal firing can be elicited intense (skin‐damaging) mechanical stimuli. The spots field are separated each other unresponsive regions, i.e., responses cannot evoked stimuli effective at spots. Fine steel pins...

Calcitonin gene-related peptide (CGRP) is a recently characterized neuroactive substance that expressed in large proportion of small- to medium-diameter sensory ganglion neurons whose central terminals lie the superficial spinal and medullary dorsal horn. This restricted distribution within peripheral nervous system suggests prominent role for nociceptive processing. The mammalian tooth pulp, which receives relatively homogeneous afferent input from thin (putative nociceptive) fibers...

Abstract The pattern of projection the rat medial lemniscus was studied by axonal transport labeling following injections tritiated leucine, proline and/or adenosine, or horseradish peroxidase for retrograde identification neurons origin. vast majority in gracile, cuneate, and principal trigeminal nuclei contribute to an almost totally crossed primarily thalamic ventrobasal complex. Additional components were traced specific sites within “posterior group”, including a component largely...

Abstract Electron microscopic examination of rat cerebral gray and white matter following formaldehyde or glutaraldehyde vascular perfusion reveals distinctive morphological features for identification oligodendrocytes. These elements are situated as satellites neurons (perikarya, dendrites axons), display a wide range nuclear cytoplasmic densities which tend to parallel each other. Cytoplasmic density appears be an uncertain criterion neuroglial identification, but oligodendrocytes...

Abstract The organization of thalamocortical relay neurons in the thalamic ventrobasal complex (VB) rat was investigated by use retrograde axonal transport horseradish peroxidase (HRP). Injections HRP into somatosensory cortex (SI) resulted a distinctive gradient neuronal and non‐neuronal reaction product. Electrophysiologically characterized points SI injected with small volumes labeled sector VB ipsilateral to injection. This zone consisted curvilinear array or lamina rostral hollow solid...