A5008831926- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Surgical Treatments
- Sarcoma Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Gallbladder and Bile Duct Disorders
- Cancer Genomics and Diagnostics
- Colorectal and Anal Carcinomas
- Esophageal and GI Pathology
- Metastasis and carcinoma case studies
- Neuroendocrine Tumor Research Advances
- Pancreatitis Pathology and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Vascular Tumors and Angiosarcomas
- Cardiac tumors and thrombi
- Hepatocellular Carcinoma Treatment and Prognosis
- Esophageal Cancer Research and Treatment
- Cancer Immunotherapy and Biomarkers
- Gastrointestinal Tumor Research and Treatment
- Economic and Financial Impacts of Cancer
- Colorectal Cancer Treatments and Studies
- Bone Tumor Diagnosis and Treatments
- Child and Adolescent Health
- Global Cancer Incidence and Screening
Duke Medical Center
2016-2025
Duke University
2014-2025
Memorial Sloan Kettering Cancer Center
2020-2024
Durham Technical Community College
2022-2024
Duke University Health System
2023
Duke Cancer Institute
2023
Duke Institute for Health Innovation
2023
Duke University Hospital
2015-2020
Hirslanden Klinik Beau-Site
2020
Clinical Orthopaedics and Related Research
2018
This study compares outcomes following pancreaticoduodenectomy (PD) for patients treated at local, low-volume centers and those traveling to high-volume centers.Although PD are superior institutions, not all live in proximity major medical centers. Theoretical advantages undergoing surgery locally exist.The 1998 2012 National Cancer Data Base was queried T1-3N0-1M0 pancreatic adenocarcinoma who underwent PD. Travel distances treatment were calculated. Overlaying the upper lower quartiles of...
This study examines short-term outcomes and pathologic surrogates of oncologic results among patients undergoing robotic versus laparoscopic low anterior resection for rectal cancer. A total 6403 met inclusion criteria. Although the approach required significantly fewer conversions to open, proper surgery were nearly identical between 2 approaches.Although (LLAR) has gained popularity as an acceptable approach, (RLAR) remains largely unproven. We compared cancer either RLAR or LLAR.All with...
Combinatorial inhibition of effector and feedback pathways is a promising treatment strategy for KRAS mutant cancers. However, the particular that should be targeted to optimize therapeutic responses are unclear. Using CRISPR/Cas9, we systematically mapped whose cooperates with drugs targeting effectors MEK, ERK, PI3K. By performing 70 screens in models colorectal, lung, ovarian, pancreas cancers, uncovered universal tissue-specific sensitizing combinations involving inhibitors cell cycle,...
Background Neoadjuvant therapy has theoretical benefits for pancreatic cancer; however, its association with perioperative outcomes remains controversial. This study sought to evaluate variation in use of neoadjuvant and following resection. Methods The National Cancer Data Base (1998‐2011) was queried patients Stage I or II adenocarcinoma who underwent pancreaticoduodenectomy. Subjects were classified by chemotherapy and/or radiation therapy. Factors associated evaluated, compared. Results...
We sought to comprehensively profile tissue and cyst fluid in patients with benign, precancerous, cancerous conditions of the pancreas characterize intrinsic pancreatic microbiome.
BACKGROUND: Controversy exists over whether resection of the primary tumor in stage IV colorectal cancer with inoperable metastases improves patient outcomes. OBJECTIVE: The purpose this study was to evaluate without metastasectomy patients is associated improved overall survival compared undergoing chemotherapy and/or radiation therapy alone. DESIGN: This a retrospective review multi-institutional dataset. SETTINGS: conducted all participating commission on (CoC)-accredited facilities....
For many cancer types, survival is improved when patients receive management at treatment centers that encounter high numbers of annually. This correlation may be more important with less common malignancies such as sarcoma. Existing evidence, however, limited and inconclusive to whether facility volume associated in soft tissue sarcoma.The purpose this study was examine the association between overall sarcoma extremities. In investigating aim, we sought (1) differences characteristics high-...
Several reports suggest that the efficacy of adjuvant chemotherapy on survival diminishes over time for colon cancer; however, precise timing its loss benefit has not been established.This study aimed to determine relationship between and identify a threshold increased risk mortality.This was retrospective study. Multivariable Cox proportional hazard modeling with restricted cubic splines used evaluate adjusted association overall establish an optimal initiation therapy.Data were collected...
Inhibitors of BCL-X L , combined with inhibition the mTOR/4E-BP axis, drive regressions PIK3CA mutant breast tumors.
In Brief Objective: To evaluate long-term survival among patients undergoing radiation therapy (RT), followed by surgical resection of retroperitoneal sarcomas (RPS). Background: Despite a lack level 1 evidence supporting neoadjuvant RT for RPS, its use has increased substantially over the past decade. Methods: The 1998–2011 National Cancer Data Base was queried to identify who underwent RPS. Subjects were grouped RT. Perioperative variables and outcomes compared. Multivariable logistic...
In the United States, race and socioeconomic status are well known predictors of adverse outcomes in several different cancers. Existing evidence suggests that may impact survival soft tissue sarcoma (STS). We investigated National Cancer Database (NCDB), which contains medical variables largest patient registry to date. Our goal was determine race, ethnicity on patients with extremities (STS-E).We retrospectively analyzed 14,067 STS-E NCDB from 1998 through 2012. Patients were stratified...
Objective: To examine survival of patients who underwent minimally invasive versus open low anterior resection (LAR) for rectal cancer. Background: Utilization laparoscopic and robotic LAR cancer has steadily increased. Short-term outcomes between these techniques surgery have shown equivalent results; however, are unknown. Methods: Adults from the National Cancer Data Base undergoing adenocarcinoma were identified. Patients stratified by intent-to-treat into (OLAR) or (MI-LAR)....
The histopathologic heterogeneity of intraductal papillary mucinous neoplasms (IPMN) complicates the prediction pancreatic ductal adenocarcinoma (PDAC) risk. Intratumoral regions pancreaticobiliary (PB), intestinal (INT), and gastric foveolar (GF) epithelium may occur with either low-grade dysplasia (LGD) or high-grade (HGD). We used digital spatial RNA profiling dysplastic (83 regions) from surgically resected IPMN tissues (12 patients) to differentiate subtypes predict genes associated...
772 Background: The therapeutic resistance of pancreatic ductal adenocarcinoma (PDAC) to conventional cytotoxic therapy underscores the need for advances in targeted molecular therapeutics. Previous studies have reported approximately 2% PDAC patients with HER2 gene amplification. While anti- cancer has yielded success other disease sites, it had minimal benefit PDAC. Multiple isoforms exist that are generated either by loss exon 16 ( d16 ), or through N-terminal truncations p95 ). These...