A5045259580- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Microbial Inactivation Methods
- Advanced biosensing and bioanalysis techniques
- Neuroendocrine Tumor Research Advances
- Pancreatitis Pathology and Treatment
- RNA Interference and Gene Delivery
- Cancer Genomics and Diagnostics
- Renal cell carcinoma treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Gallbladder and Bile Duct Disorders
- RNA and protein synthesis mechanisms
- Cancer, Hypoxia, and Metabolism
- Neuroblastoma Research and Treatments
- Gastrointestinal Tumor Research and Treatment
- Ferroptosis and cancer prognosis
- Nanoplatforms for cancer theranostics
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Adenosine and Purinergic Signaling
- Cell Adhesion Molecules Research
- Gastrointestinal disorders and treatments
- Cancer Research and Treatments
- Peptidase Inhibition and Analysis
University of California, San Diego
2017-2025
UC San Diego Health System
2024-2025
Délégation Paris 6
2021-2024
Moores Cancer Center
2018-2024
Kuwait Petroleum Corporation (Kuwait)
2021-2024
Hochschule Düsseldorf University of Applied Sciences
2021-2024
The Bronx Defenders
2024
Sandia National Laboratories
2023
Indianapolis Zoo
2021
Los Angeles City College
2021
Abstract Radiotherapy represents the most effective nonsurgical treatments for gliomas. However, gliomas are highly radioresistant and recurrence is nearly universal. Results from our laboratory other groups suggest that cancer stem cells contribute to radioresistance in breast cancers. The Notch pathway critically implicated cell fate determination cancer. In this study, we show inhibition of with γ-secretase inhibitors (GSIs) renders glioma more sensitive radiation at clinically relevant...
Nucleic acid
Species cross-reactivity facilitates the preclinical evaluation of potentially therapeutic molecules in animal models. Here we describe an vitro selection strategy which RNA ligands (aptamers) that bind both human and porcine thrombin were selected by "toggling" protein target between during alternating rounds selection. The "toggle" process yielded a family aptamers, all bound with high affinity. Toggle-25, characteristic member, inhibited two thrombin's most important functions: plasma...
Abstract BACKGROUND: During chemotherapy, some colorectal liver metastases (LMs) disappear on serial imaging. This disappearance may represent a complete response (CR) or reduction in the sensitivity of imaging during chemotherapy. The objective current study was to determine fate disappearing LMs (DLMs) and factors that predict true CR. METHODS: Between 2000 2003, 435 patients who were evaluated by hepatobiliary surgeons received chemotherapy before they considered for resection. Inclusion...
Neuroendocrine tumors comprise a broad family of tumors, the most common which are carcinoid and pancreatic neuroendocrine tumors. The NCCN Tumors Guidelines discuss diagnosis management both sporadic hereditary Most recommendations pertain to well-differentiated, low- intermediate-grade This updated version includes new section on pathology for reporting revised surgical pancreas.
Aptamers, an emerging class of therapeutics, are DNA or RNA molecules that selected to bind molecular targets range from small organic compounds large proteins. All the determined structures aptamers in complex with molecule show cage such ligands. In proteins naturally nucleic acid, occupy acid binding site and often mimic natural interactions. Here we present a crystal structure aptamer bound human thrombin, protein does not at 1.9 Å resolution. The aptamer, which adheres thrombin for...
Abstract Irreversible electroporation (IRE) is a nonthermal ablation technique that used clinically in selected patients with locally advanced pancreatic cancer, but most develop recurrent distant metastatic disease. We hypothesize IRE can induce an situ vaccination effect by releasing tumor neoantigens inflammatory context. Using immunocompetent mouse model, we demonstrated alone produced complete regression of subcutaneous tumors approximately 20% to 30% mice. was not effective...
High-grade serous ovarian cancer (HGSOC) is a lethal malignancy characterized by an immunosuppressive tumor microenvironment containing few infiltrating lymphocytes (TILs) and insensitivity to checkpoint inhibitor immunotherapies. Gains in the PTK2 gene encoding focal adhesion kinase (FAK) at Chr8 q24.3 occur ∼70% of HGSOC tumors, elevated FAK messenger RNA (mRNA) levels are associated with poor patient survival. Herein, we show that active FAK, phosphorylated tyrosine-576 within catalytic...
TPS787 Background: Irreversible electroporation (IRE) is a form of non-thermal tumor ablation that currently in clinical use for selected patients with locally advanced pancreatic cancer (LAPC). Preclinical and studies have suggested IRE generates an situ vaccination effect by releasing neoantigens the setting inflammation. Our published data from syngeneic, orthotopic mouse models demonstrate combination local CD40 agonism induces systemic anti-tumor immune effects, including...
Angiopoietin-2 (Ang2) appears to be a naturally occurring antagonist of the endothelial receptor tyrosine kinase Tie2, an important regulator vascular stability. Destabilization endothelium by Ang2 is believed potentiate actions proangiogenic growth factors. To investigate specific role in adult vasculature, we generated nuclease-resistant RNA aptamer that binds and inhibits but not related Tie2 agonist, angiopoietin-1. Local delivery this partially scrambled mutant inhibited basic...
Objective To examine the long-term outcomes of patients with melanoma metastatic to regional lymph nodes. Summary Background Data Regional node metastasis is a major determinant outcome for melanoma, and presence has been commonly used as an indication systemic, often intensive, adjuvant therapy. However, risk recurrence varies greatly within this heterogeneous group patients. Methods Database review identified 2,505 patients, referred Duke University Melanoma Clinic between 1970 1998,...
PURPOSE We evaluated weekly single-agent intravenous (IV) vinorelbine as salvage therapy for metastatic breast cancer. After the first five patients, all received elective growth factor support with granulocyte colony-stimulating (G-CSF; filgrastim) in an attempt to maximize delivered dose-intensity (DDI). Objective tumor response, DDI, and toxicity were assessed, well time progression (TTP) survival. PATIENTS AND METHODS This single-center nonrandomized trial enrolled 40 patients....