A5047595470- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Renal Transplantation Outcomes and Treatments
- Transplantation: Methods and Outcomes
- Organ Donation and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA Interference and Gene Delivery
- Clinical Nutrition and Gastroenterology
- Polyomavirus and related diseases
- Colorectal Cancer Treatments and Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Tissue Engineering and Regenerative Medicine
- Virus-based gene therapy research
- Renal and Vascular Pathologies
- Gallbladder and Bile Duct Disorders
- Gastrointestinal disorders and treatments
- Viral-associated cancers and disorders
- Pancreatitis Pathology and Treatment
- Aortic aneurysm repair treatments
- Immune Response and Inflammation
- Hepatitis C virus research
- Colorectal Cancer Surgical Treatments
Duke University
2013-2025
Duke Medical Center
2014-2024
Duke University Health System
2018-2024
Duke University Hospital
2008-2024
Yahoo (United Kingdom)
2024
University Health Network
2016-2018
University of Toronto
2015-2018
Toronto General Hospital
2015-2018
Duke Raleigh Hospital
2014
Durham University
2011
The selection of liver transplant candidates with hepatocellular carcinoma (HCC) relies mostly on tumor size and number. Instead relying these factors, we used poor differentiation cancer-related symptoms to exclude patients likely have advanced HCC aggressive biology. We initially reported similar 5-year survival for whose tumors exceeded (M+ group) were within (M the Milan criteria. Herein, validate our original data a new prospective cohort report long-term follow-up (10-years) using an...
To compare conventional low-temperature storage of transplant donor livers [static cold (SCS)] with the organs at physiological body temperature [normothermic machine perfusion (NMP)].
Abstract BACKGROUND. Surgical strategy for hilar cholangiocarcinoma often includes hepatectomy, but the role of portal vein resection (PVR) remains controversial. In this study, authors sought to identify factors associated with outcome after surgical management and examined impact PVR on survival. METHODS: Three hundred five patients who underwent curative‐intent surgery between 1984 2010 were identified from an international, multi‐institutional database. Clinicopathologic data evaluated...
Genetic modification of porcine donors, combined with optimized immunosuppression, has been shown to improve outcomes experimental xenotransplant. However, little is known about in sensitized recipients, a population that could potentially benefit the most from clinical implementation xenotransplantation. Here, five highly allosensitized rhesus macaques received kidney
A laparoscopic approach has been proposed to reduce the high morbidity and mortality associated with Hartmann procedure for emergency treatment of diverticulitis.The objective our study was determine whether a reduces early or patients undergoing an operation diverticulitis.This is comparative effectiveness study. subset entire American College Surgeons National Surgical Quality Improvement Program patient sample matched on propensity their were used compare postoperative outcomes between...
Normothermic ex vivo liver perfusion (NEVLP) improves graft preservation by avoiding cold ischemia injury. We investigated whether the protective effects of NEVLP can be further improved applying strategies targeted on reducing activation proinflammatory cytokines during perfusion. Livers retrieved under heart-beating conditions were perfused for 4 hours. Following period, a pig transplantation was performed. In group 1 (n = 5), anti-inflammatory (alprostadil, n-acetylcysteine, carbon...
The innate immune system is a critical regulator of the adaptive responses that lead to allograft rejection. It increasingly recognized endogenous molecules released from tissue injury and cell death are potent activators immunity. Mitochondria, ancestrally related bacteria, possess an array immune-activating molecules. We have recently demonstrated extracellular mitochondria abundant in circulation deceased organ donors their presence correlates with early dysfunction. Here we demonstrate...
Significance Statement Although common desensitization strategies for patients with broad HLA sensitization permit transplantation via transient lowering of donor-specific antibodies, the B cell–response axis from germinal center activation to plasma cell differentiation remains intact. In this study, dual-targeting carfilzomib (a proteasome inhibitor) and belatacept costimulation blockade agent) prolonged allograft survival in highly sensitized nonhuman primates; it appears inhibit cells,...
Multiple organ failure (MOF) is the leading cause of late mortality and morbidity in patients who are admitted to intensive care units (ICUs). However, there an epidemiologic discrepancy mechanism underlying immunologic derangement dependent on etiology between sepsis trauma MOF. We hypothesized that damage-associated molecular patterns (DAMPs) pathogen-associated (PAMPs), while both involved development MOF, contribute differently systemic innate immune coagulopathic changes. found DAMPs...
HCC recurrence following liver transplantation (LT) is highly morbid and occurs despite strict patient selection criteria. Individualized prediction of post-LT risk remains an important need. Clinico-radiologic pathologic data 4981 patients with undergoing LT from the US Multicenter Transplant Consortium (UMHTC) were analyzed to develop a REcurrent Liver cAncer Prediction ScorE (RELAPSE). Multivariable Fine Gray competing analysis machine learning algorithms (Random Survival Forest...
Objectives To compare outcomes and the use of multimodality therapy in young elderly people with pancreatic cancer undergoing surgical resection. Design Retrospective, single‐institution study. Setting National Cancer Institute/National Comprehensive Network center. Participants Two hundred three individuals who underwent pancreaticoduodenectomy for adenocarcinoma at Duke University Medical Center comprised study population. were divided into groups based on age (<65, n = 97; 65–74, 74;...
Abstract BACKGROUND: Before the advent of tyrosine kinase inhibitors (TKIs), surgical resection was primary treatment for hepatic gastrointestinal stromal tumor (GIST) metastases. Although TKIs have improved survival in metastatic setting, outcomes after multimodal therapy comprised hepatectomy and GIST are unknown. The objective this study to determine whether combination metastases is associated with overall compared reported from surgery or TKI alone. METHODS: Demographics,...