A5026301572- Cutaneous Melanoma Detection and Management
- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- CAR-T cell therapy research
- Melanoma and MAPK Pathways
- Aortic aneurysm repair treatments
- Angiogenesis and VEGF in Cancer
- Colorectal Cancer Surgical Treatments
- Nanoplatforms for cancer theranostics
- TGF-β signaling in diseases
- Colorectal and Anal Carcinomas
- Immunotherapy and Immune Responses
- Cerebrovascular and Carotid Artery Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Prostate Cancer Treatment and Research
- Colorectal Cancer Screening and Detection
- Venous Thromboembolism Diagnosis and Management
- Optical Coherence Tomography Applications
- Gastric Cancer Management and Outcomes
- Gallbladder and Bile Duct Disorders
- Intracranial Aneurysms: Treatment and Complications
- Brain Metastases and Treatment
- Glutathione Transferases and Polymorphisms
- Prostate Cancer Diagnosis and Treatment
Peripheral Vascular Associates
2017-2024
Duke University
2008-2019
Duke Medical Center
2009-2018
Duke University Hospital
2011-2016
Clinical Research Institute
2016
Durham VA Medical Center
2012
Johns Hopkins University
2011
Weatherford College
2009
Immunovaccine (Canada)
2007
Purpose To identify factors associated with outcome after surgical management of intrahepatic cholangiocarcinoma (ICC) and examine the impact lymph node (LN) assessment on survival. Patients Methods From an international multi-institutional database, 449 patients who underwent surgery for ICC between 1973 2010 were identified. Clinical pathologic data evaluated using uni- multivariate analyses. Results Median tumor size was 6.5 cm. Most had a solitary (73%) no vascular invasion (69%)....
Abstract The transforming growth factor-β (TGF-β) signaling pathway has an important role in regulating normal prostate epithelium, inhibiting proliferation, differentiation, and both androgen deprivation–induced androgen-independent apoptosis. During cancer formation, most cells become resistant to these homeostatic effects of TGF-β. Although the loss expression either type I (TβRI) or II (TβRII) TGF-β receptor been documented ∼30% cancers, cancers without mutation deletion TβRI, TβRII,...
The transforming growth factor-β (TGF-β) superfamily has essential roles in lung development, regulating cell proliferation, branching morphogenesis, differentiation and apoptosis. Although most cancers become resistant to the tumor suppressor effects of TGF-β, loss or mutation one components TGF-β signaling pathway, including TβRII, Smad2 Smad4 have been reported, mutations are not common non-small cancer (NSCLC). Here we demonstrate that co-receptor, type III receptor (TβRIII betaglycan)...
Controversy exists over how long trials of nonoperative management should be pursued in patients with uncomplicated adhesive small bowel obstructions (ASBOs) before deciding to proceed surgery. The purpose this study was determine the effect incremental delays surgery on 30-day postoperative outcomes undergoing for ASBO.American College Surgeons National Surgical Quality Improvement Program 2005-2011 data were used identify ASBO whom a trial attempted. Multivariate logistic or linear...
Rectourethral fistulas are an uncommon, yet devastating occurrence after treatment for prostate cancer or trauma, and their surgical management has historically been nonstandardized. Anecdotally, irradiated rectourethral portend a worse prognosis.To review outcomes of in radiated nonirradiated patients to construct logical algorithm.A retrospective was undertaken all presenting Duke University with the diagnosis fistula from 1996 2012.Thirty-seven presented were treated fistulas: 21 received...
A laparoscopic approach has been proposed to reduce the high morbidity and mortality associated with Hartmann procedure for emergency treatment of diverticulitis.The objective our study was determine whether a reduces early or patients undergoing an operation diverticulitis.This is comparative effectiveness study. subset entire American College Surgeons National Surgical Quality Improvement Program patient sample matched on propensity their were used compare postoperative outcomes between...
Objectives To compare outcomes and the use of multimodality therapy in young elderly people with pancreatic cancer undergoing surgical resection. Design Retrospective, single‐institution study. Setting National Cancer Institute/National Comprehensive Network center. Participants Two hundred three individuals who underwent pancreaticoduodenectomy for adenocarcinoma at Duke University Medical Center comprised study population. were divided into groups based on age (<65, n = 97; 65–74, 74;...
Abstract BACKGROUND: Before the advent of tyrosine kinase inhibitors (TKIs), surgical resection was primary treatment for hepatic gastrointestinal stromal tumor (GIST) metastases. Although TKIs have improved survival in metastatic setting, outcomes after multimodal therapy comprised hepatectomy and GIST are unknown. The objective this study to determine whether combination metastases is associated with overall compared reported from surgery or TKI alone. METHODS: Demographics,...
Needle biopsy Gleason scores are often upgraded after pathological examination of the prostate following radical prostatectomy. It has been suggested that larger prostates would be associated with a greater risk upgrading since smaller percentage gland is sampled and, thus, highest grade disease more likely missed, assuming an equal number cores taken from similar locations. We examined likelihood clinically relevant prostatectomy as function transrectal ultrasound volume.We association...
To investigate whether the systemically administered anti-VEGF monoclonal antibody bevacizumab could improve regional chemotherapy treatment of advanced extremity melanoma by enhancing delivery and tumor uptake regionally infused melphalan (LPAM).After with systemic or saline, changes in vascular permeability were determined spectrophotometric analysis tumors Evan's blue dye. Changes structure hemoglobin-oxygen saturation HbO(2) intravital microscopy diffuse reflectance spectroscopy,...