A5090293033- Organ Transplantation Techniques and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Renal Transplantation Outcomes and Treatments
- Liver Disease and Transplantation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Transplantation: Methods and Outcomes
- Innovations in Medical Education
- Liver Diseases and Immunity
- COVID-19 Clinical Research Studies
- Cardiac Structural Anomalies and Repair
- Patient-Provider Communication in Healthcare
- Cardiac, Anesthesia and Surgical Outcomes
- Healthcare professionals’ stress and burnout
- Mechanical Circulatory Support Devices
- Renal and Vascular Pathologies
- Neuroendocrine Tumor Research Advances
- Pneumocystis jirovecii pneumonia detection and treatment
- Organ Donation and Transplantation
- Hepatitis C virus research
- Surgical Simulation and Training
- Patient Safety and Medication Errors
- Drug Transport and Resistance Mechanisms
- HIV/AIDS drug development and treatment
- Diversity and Career in Medicine
University of California, San Diego
2015-2024
UC San Diego Health System
2024
Policlinico Umberto I
2023
VA San Diego Healthcare System
2023
Penn Center for AIDS Research
2022
University of Pennsylvania
2022
University of San Diego
2022
Naval Medical Center San Diego
2015
Stanford University
2013-2014
Stanford Medicine
2014
To evaluate the effect of pretransplant bridging locoregional therapy (LRT) on hepatocellular carcinoma (HCC) recurrence and survival after liver transplantation (LT) in patients meeting Milan criteria (MC).Pre-LT LRT mitigates tumor progression waitlist dropout HCC within MC, but data its impact post-LT remain limited.Recurrence-free were compared among 3601 MC with without utilizing competing risk Cox regression consecutive from 20 US centers (2002-2013).Compared 747 LT recipients not...
Background and Aims The Organ Procurement Transplantation Network recently approved liver transplant (LT) prioritization for patients with hepatocellular carcinoma (HCC) beyond Milan Criteria (MC) who are down‐staged (DS) locoregional therapy (LRT). We evaluated post‐LT outcomes, predictors of down‐staging, the impact LRT in beyond‐MC HCC from U.S. Multicenter Transplant Consortium (20 centers, 2002‐2013). Approach Results Clinicopathologic characteristics, overall survival (OS),...
The aim of the study was to determine rate, predictors, and impact complete pathologic response (cPR) pretransplant locoregional therapy (LRT) in a large, multicenter cohort hepatocellular carcinoma (HCC) patients undergoing liver transplantation (LT).LRT is used mitigate waitlist dropout for with HCC awaiting LT. Degree tumor necrosis found on explant has been associated recurrence overall survival, but not evaluated study.Comparisons were made among receiving pre-LT LRT (n = 802) without...
HCC recurrence following liver transplantation (LT) is highly morbid and occurs despite strict patient selection criteria. Individualized prediction of post-LT risk remains an important need. Clinico-radiologic pathologic data 4981 patients with undergoing LT from the US Multicenter Transplant Consortium (UMHTC) were analyzed to develop a REcurrent Liver cAncer Prediction ScorE (RELAPSE). Multivariable Fine Gray competing analysis machine learning algorithms (Random Survival Forest...
Background Donation after circulatory death (DCD) liver allografts are associated with higher rates of primary non-function (PNF) and ischemic cholangiopathy (IC). Advanced recovery techniques, including thoracoabdominal normothermic regional perfusion (TA-NRP), may improve organ utilization patient allograft outcomes. Given the increasing US experience TA-NRP DCD recovery, we evaluated outcomes transplanted TA-NRP. Methods Liver from donors were identified 5/1/2021 to 1/31/2022 across 8...
NAFLD will soon be the most common indication for liver transplantation (LT). In NAFLD, HCC may occur at earlier stages of fibrosis and present with more advanced tumor stage, raising concern aggressive disease. Thus, adult LT recipients from 20 US centers transplanted between 2002 2013 were analyzed to determine whether impacts recurrence-free post-LT survival. Five hundred thirty-eight (10.8%) 4981 total patients had NAFLD. Patients significantly older (63 vs. 58, p <0.001), higher body...
Abstract A 7-day course of glecaprevir/pibrentasvir started in the preoperative period prevented transmission hepatitis C virus (HCV) from viremic donors to 10 HCV-negative recipients (2 heart, 1 lung, 6 kidney, heart/kidney) with 100% sustained virological response at 12 weeks.
Although intra-operative vascular complications during renal transplantation are rare, injuries associated with prolonged ischemia may lead to graft threatening early and late complications. This series describes a novel technique for repair of in five patients over three-yr period. The method consists rapid nephrectomy re-preservation the cold University Wisconsin solution, which allows controlled/precise back table injury without incurring warm time. In three cases, donor vein (2) artery...
On June 18, 2013, the United Network for Organ Sharing (UNOS) instituted a change in liver transplant allocation policy known as “Share 35.” The goal was to decrease waitlist mortality by increasing regional sharing of livers patients with model end-stage disease (MELD) score 35 or above. Several studies have shown Share successful reducing mortality, particularly high MELD. However, MELD at has increased, resulting sicker patients, more complications, and longer hospital stays. Our study...
The incidence of hepatocellular carcinoma (HCC) is growing in the United States, especially among elderly. Older patients are increasingly receiving transplants as a result HCC, but impact advancing age on long-term posttransplant outcomes not clear. To study this, we used data from US Multicenter HCC Transplant Consortium 4980 patients. We divided into 4 groups by at transplantation: 18 to 64 years (n = 4001), 65 69 683), 70 74 252), and ≥75 44). There were no differences tumor stage, type...