A5030880139- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Liver Disease Diagnosis and Treatment
- Organ Donation and Transplantation
- Transplantation: Methods and Outcomes
- SARS-CoV-2 and COVID-19 Research
- Congenital Anomalies and Fetal Surgery
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Diseases and Immunity
- Neurological Complications and Syndromes
- Pregnancy and Medication Impact
- Hepatitis C virus research
- COVID-19 Clinical Research Studies
- Metabolism and Genetic Disorders
- Renal and Vascular Pathologies
- Cardiovascular Disease and Adiposity
- Vascular anomalies and interventions
- Genetic and Kidney Cyst Diseases
- Abdominal vascular conditions and treatments
- Autoimmune and Inflammatory Disorders Research
- Renal Diseases and Glomerulopathies
- Abdominal Surgery and Complications
The University of Texas Medical Branch at Galveston
2020-2025
NHS Blood and Transplant
2022
Baylor College of Medicine
2007-2020
Texas Children's Hospital
2016-2020
Mount Sinai Hospital
2019
Mount Sinai Medical Center
2019
In-Q-Tel
2016
Children's Nutrition Research Center at Baylor College of Medicine
2010
University of Houston
2007-2009
St. Mary's University, Texas
2008
To evaluate the effect of pretransplant bridging locoregional therapy (LRT) on hepatocellular carcinoma (HCC) recurrence and survival after liver transplantation (LT) in patients meeting Milan criteria (MC).Pre-LT LRT mitigates tumor progression waitlist dropout HCC within MC, but data its impact post-LT remain limited.Recurrence-free were compared among 3601 MC with without utilizing competing risk Cox regression consecutive from 20 US centers (2002-2013).Compared 747 LT recipients not...
The health benefits of pomegranate consumption have recently received considerable scientific focus, with most studies examining fruit and/or juice consumption. Pomegranate seed oil (POMo) is a rich source 9- cis , 11- trans conjugate linolenic acid (CLA), which may offset the side-effects associated weight gain. Male, wild-type CD-1 mice were divided into one three groups (twenty per group): high-fat (HF), HF+seed (HF+POMo) or lean control (LN). In HF and HF+POMo, provided access ad libitum...
Objective: The aim of this study was to assess improvements in long-term survival after liver transplant by analyzing outcomes recipients who survived beyond 1 year. Summary Background Data: Gains short-term following transplantation have been gratifying. One-year 1986 66% improved over 92% 2015. However, little is known about why has not seen similar success. Methods: We analyzed 111,568 from 1987 2016 using the Kaplan-Meier method for time-to-event analysis and multivariable Cox...
Background and Aims The Organ Procurement Transplantation Network recently approved liver transplant (LT) prioritization for patients with hepatocellular carcinoma (HCC) beyond Milan Criteria (MC) who are down‐staged (DS) locoregional therapy (LRT). We evaluated post‐LT outcomes, predictors of down‐staging, the impact LRT in beyond‐MC HCC from U.S. Multicenter Transplant Consortium (20 centers, 2002‐2013). Approach Results Clinicopathologic characteristics, overall survival (OS),...
The aim of the study was to determine rate, predictors, and impact complete pathologic response (cPR) pretransplant locoregional therapy (LRT) in a large, multicenter cohort hepatocellular carcinoma (HCC) patients undergoing liver transplantation (LT).LRT is used mitigate waitlist dropout for with HCC awaiting LT. Degree tumor necrosis found on explant has been associated recurrence overall survival, but not evaluated study.Comparisons were made among receiving pre-LT LRT (n = 802) without...
Risk analysis of cold ischemia time (CIT) in liver transplantation has largely focused on patient and graft survival. Posttransplant length stay is a sensitive marker morbidity cost. We hypothesize that CIT risk factor for posttransplant prolonged (PLOS) aim to conduct an hour‐by‐hour PLOS. retrospectively reviewed all adult, first‐time transplants between March 2002 September 2016 the United Network Organ Sharing database. The 67,426 recipients were categorized by hourly increments....
Low case volume has been associated with poor outcomes in a wide spectrum of procedures. Our objective was to study the association low and worse pediatric heart transplant centers, taking novel approach including waitlist analysis. We studied cohort 6482 candidates listed Organ Procurement Transplantation Network for transplantation between 2002 2014; 4665 (72%) underwent transplantation. Candidates were divided into groups according average annual listing center during period: more than...
An index that predicts liver allograft discard can effectively grade allografts and be used to preferentially allocate marginal aggressive centers. The aim of this study is devise an predict using only risk factors available at the time initial DonorNet offer.Using univariate multivariate analyses on a training set 72 297 deceased donors, we identified independent for discard. Multiple imputation was account missing variables.We 15 as significant predictors discard; most were: total...
Autoimmune hepatitis (AIH) and primary biliary cholangitis (PBC) are immune-mediated liver diseases (IMLDs) that diagnosed by a combination of clinical, serologic, histologic features. Diagnosis may be challenging, particularly when patients have mixed features both AIH PBC, disease often called overlap syndrome (OS). In addition, many refractory disease. We hypothesized adding molecular testing to the current diagnostic criteria would provide an additional tool could assist in correctly...
An index to predict hospital length of stay after liver transplantation could address unmet clinical needs. Length is an important surrogate for costs and efforts limit stays can preserve our healthcare resources. Here, we devised a scoring system that predicts following transplantation. We used univariate multivariate analyses on 73 635 adult transplant recipient data identified independent donor risk factors prolonged (>30 days). Multiple imputation was account missing variables. 22 as...
The purposes of this study were to analyze the effects an ERS on time transplantation and describe our center's experience with OLT for HB. Patients who received HB between 2000 2013 included. Patient allograft characteristics, chemotherapy regimens, prior surgical therapies examined. interval diagnosis following institution transplant was compared. Survival tumor recurrence analyzed. Nineteen patients (mean age 33 months). All children grafts from deceased donors. Two underwent resections....
Direct-acting antivirals (DAA) have replaced interferon (IFN)-based therapies for hepatitis C virus. In this retrospective clinical study, we examined differences in histopathologic features paired liver biopsies collected from the same patient before and after DAA correlated these findings with outcome. Biopsies (n = 19) were evaluated by quantitative imaging analysis to measure steatosis fibrosis. Most patients had decreased their post-treatment, follow-up biopsies. However, one a striking...
The purpose of the present study was to determine effect body weight on blood lipid profile, insulin resistance and inflammatory biomarkers in Mexican-American children.Children (13.3+/-0.1 year) were recruited from a local school assigned one three groups as volunteer sample: healthy (HW) (> or =10th <85th BMI percentile; n=42), at risk overweight (RO) =85th <95th; n =25) (OW) =95th; n=42). Plasma concentrations hsCRP, sCD14, sIL-6R, sTNF-alphaR1, sTNF-alphaR2, IL-6 TNF-alpha determined by...
Obesity is associated with an increase in chronic, low-grade inflammation which has been implicated the development of type 2 diabetes mellitus and cardiovascular disease. The purpose this study was to determine whether obesity elevation whole blood lipopolysaccharide (LPS)-stimulated tumor necrosis factor-alpha (TNF-alpha) production. African-American women were recruited from a larger assigned one five groups based on BMI: normal weight (NORM; BMI 20-25, n = 7), overweight (OVER; 25-30,...
Carbohydrate consumption during strenuous aerobic exercise reportedly minimizes post-exercise suppression of the innate immune system. One most common measurements immunity is natural killer cell activity (NKCA). It not known whether actual carbohydrate or merely knowledge mediates alteration in NKCA. The purpose present investigation was to determine if beverage could result RPE and NKCA, independent intake. We recruited 11 male female endurance athletes randomly assigned them either a...