A5075527209- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Renal Transplantation Outcomes and Treatments
- Liver Disease Diagnosis and Treatment
- Transplantation: Methods and Outcomes
- Organ Donation and Transplantation
- Hepatitis C virus research
- Hepatocellular Carcinoma Treatment and Prognosis
- Renal and Vascular Pathologies
- Mechanical Circulatory Support Devices
- COVID-19 Clinical Research Studies
- Liver Diseases and Immunity
- COVID-19 Impact on Reproduction
- Pediatric Hepatobiliary Diseases and Treatments
- Neurological Complications and Syndromes
- Cardiac Structural Anomalies and Repair
- Pregnancy and Medication Impact
- Dialysis and Renal Disease Management
- Hepatitis B Virus Studies
- Gallbladder and Bile Duct Disorders
- Alcohol Consumption and Health Effects
- Electrolyte and hormonal disorders
- Metabolism and Genetic Disorders
- Cardiac Arrest and Resuscitation
- Grief, Bereavement, and Mental Health
Baylor College of Medicine
2016-2025
Michael E. DeBakey VA Medical Center
2023-2025
Duke Medical Center
2023
Baylor University Medical Center
2023
Baylor University
2023
Weill Cornell Medicine
2022
Cornell University
2022
St. Luke's Hospital
2022
Texas Children's Hospital
2015-2021
Mount Sinai Hospital
2019
The field of transplantation has made tremendous progress since the first successful kidney transplant in 1954.To determine survival benefit solid-organ as recorded during a 25-year study period United Network for Organ Sharing (UNOS) database and Social Security Administration Death Master File.In this retrospective analysis UNOS data (September 1, 1987, through December 31, 2012), we reviewed records 1,112,835 patients: 533,329 recipients who underwent 579 506 patients were placed on...
It is critical to balance waitlist mortality against posttransplant mortality. Our objective was devise a scoring system that predicts recipient survival at 3 months following liver transplantation complement MELD-predicted Univariate and multivariate analysis on 21,673 transplant recipients identified independent donor risk factors for A retrospective conducted 30,321 waitlisted candidates reevaluated the predictive ability of Model End-Stage Liver Disease (MELD) score. We 13 factors, 4 2...
The Milan criteria have been adopted by United Network for Organ Sharing (UNOS) to preoperatively assess outcome in patients with hepatocellular carcinoma (HCC) who receive orthotopic liver transplantation (OLT). These rely solely on radiographic appearances of the tumor, providing no measure tumor biology. Recurrence rates, therefore, remain around 20% within criteria. neutrophil-lymphocyte ratio (NLR) is an indicator inflammatory status previously established as a prognostic colorectal...
To identify medical predictors of futility in recipients with laboratory Model End-Stage Liver Disease (MELD) scores 40 or more at the time orthotopic liver transplantation (OLT).Although survival benefit for transplant patients highest MELD is indisputable, and economic effort to bring these acuity through OLT presents a major challenge every center.This study was undertaken analyze outcomes undergoing during period February 2002 December 2010. The analysis focused on futile outcome...
To evaluate the effect of pretransplant bridging locoregional therapy (LRT) on hepatocellular carcinoma (HCC) recurrence and survival after liver transplantation (LT) in patients meeting Milan criteria (MC).Pre-LT LRT mitigates tumor progression waitlist dropout HCC within MC, but data its impact post-LT remain limited.Recurrence-free were compared among 3601 MC with without utilizing competing risk Cox regression consecutive from 20 US centers (2002-2013).Compared 747 LT recipients not...
Priority is given to patients with hepatocellular carcinoma (HCC) receive liver transplants, potentially causing significant regional disparities in organ access and possibly outcomes this population. Our aim was assess these by comparing long waiting time regions (LWTR, 5 9) short (SWTR 3 10) analyzing the United Network for Organ Sharing (UNOS) database. We analyzed 6,160 HCC who received exception points 3, 5, 9, 10 from 2002 2012. Data 9 were combined compared data 10. Survival studied...
Objective: The aim of this study was to assess improvements in long-term survival after liver transplant by analyzing outcomes recipients who survived beyond 1 year. Summary Background Data: Gains short-term following transplantation have been gratifying. One-year 1986 66% improved over 92% 2015. However, little is known about why has not seen similar success. Methods: We analyzed 111,568 from 1987 2016 using the Kaplan-Meier method for time-to-event analysis and multivariable Cox...
Background and Aims The Organ Procurement Transplantation Network recently approved liver transplant (LT) prioritization for patients with hepatocellular carcinoma (HCC) beyond Milan Criteria (MC) who are down‐staged (DS) locoregional therapy (LRT). We evaluated post‐LT outcomes, predictors of down‐staging, the impact LRT in beyond‐MC HCC from U.S. Multicenter Transplant Consortium (20 centers, 2002‐2013). Approach Results Clinicopathologic characteristics, overall survival (OS),...
Background and Aims The surge in unhealthy alcohol use during the COVID‐19 pandemic may have detrimental effects on rising burden of alcohol‐associated liver disease (ALD) transplantation (LT) USA. We evaluated effect temporal trends for LT including ALD. Approach Results Using data from United Network Organ Sharing, we analyzed wait‐list outcomes USA through March 1, 2021. In a short‐period analysis, patients listed or transplanted between June 2019, February 29, 2020, were defined as...
The aim of the study was to determine rate, predictors, and impact complete pathologic response (cPR) pretransplant locoregional therapy (LRT) in a large, multicenter cohort hepatocellular carcinoma (HCC) patients undergoing liver transplantation (LT).LRT is used mitigate waitlist dropout for with HCC awaiting LT. Degree tumor necrosis found on explant has been associated recurrence overall survival, but not evaluated study.Comparisons were made among receiving pre-LT LRT (n = 802) without...
With continuing improvements in medical devices and more than a decade since the 2006 United Network for Organ Sharing (UNOS) allocation policy, it is pertinent to assess survival among patients on heart transplantation waiting list, especially given recently approved 2018 UNOS policy.To outcomes transplant list during past 3 decades examine association of ventricular assist (VADs) policy with survival.A retrospective cross-sectional used database perform an analysis 95 323 candidates...
The clinical course of COVID-19 in pediatric solid organ transplant recipients remains ambiguous. Though preliminary experiences with adult have been published, literature centered on the population is limited. We herein report a multi-center, multi-organ cohort analysis COVID-19-positive ≤ 18 years at time transplant. Data were collected via institutions' respective electronic medical record systems. Local review boards approved this cross-institutional study. Among 5 centers, 26 patients...
Background and Aims: In liver transplantation, cold preservation induces ischemia, resulting in significant reperfusion injury. Hypothermic oxygenated machine perfusion (HMP-O 2 ) has shown benefits compared to static storage (SCS) by limiting ischemia-reperfusion This study reports outcomes using a novel portable HMP-O device the first US randomized control trial. Approach Results: The PILOT trial (NCT03484455) was multicenter, randomized, open-label, noninferiority trial, with participants...
To further our understanding of the potential protective effects one organ allograft for another in combined transplants by comparing rejection-free survival and 1-year rejection rate each type transplant.Liver allografts have been thought to be immunoprotective other donor-specific allografts. Recent observations extended this property organs.Analysis data from United Network Organ Sharing included recipients 18 years or older (except those receiving intestinal transplants) transplanted...
The field of liver transplantation has shifted considerably in the MELD era, including changing allocation, immunosuppression, and failure etiologies, as well better supportive therapies. Our aim was to evaluate predictive accuracy score over time. United Network for Organ Sharing provided de-identified data on 120 156 patients listed transplant from 2002-2016. ability predict 90-day mortality evaluated by a concordance (C-) statistic corroborated with competing risk analysis. score's...
Investigating outcomes after marginal allograft transplant is essential in determining appropriate and more aggressive use of these allografts.
Risk analysis of cold ischemia time (CIT) in liver transplantation has largely focused on patient and graft survival. Posttransplant length stay is a sensitive marker morbidity cost. We hypothesize that CIT risk factor for posttransplant prolonged (PLOS) aim to conduct an hour‐by‐hour PLOS. retrospectively reviewed all adult, first‐time transplants between March 2002 September 2016 the United Network Organ Sharing database. The 67,426 recipients were categorized by hourly increments....
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a novel coronavirus responsible for worldwide pandemic has forced drastic changes in medical practice an alarmingly short period of time. Caregivers must modify their strategies as well optimize the utilization resources to ensure public and patient safety. For organ transplantation, particular, loss lifesaving organs transplantation could lead increased waitlist mortality. The priority is select uninfected donors transplant...
Organ scarcity means few patients with advanced liver disease undergo a transplant, making equitable distribution all the more crucial. Disparities may arise at any stage in complex process leading up to this curative therapy.To examine rate of and factors associated referral, wait-listing, receipt allografts.This retrospective cohort study used linked data from comprehensive electronic medical records United Network Sharing. Adult cirrhosis Model for End-Stage Liver Disease addition sodium...
HCC recurrence following liver transplantation (LT) is highly morbid and occurs despite strict patient selection criteria. Individualized prediction of post-LT risk remains an important need. Clinico-radiologic pathologic data 4981 patients with undergoing LT from the US Multicenter Transplant Consortium (UMHTC) were analyzed to develop a REcurrent Liver cAncer Prediction ScorE (RELAPSE). Multivariable Fine Gray competing analysis machine learning algorithms (Random Survival Forest...