A5017994911- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Transplantation: Methods and Outcomes
- Cardiac and Coronary Surgery Techniques
- Organ Transplantation Techniques and Outcomes
- Cardiac Arrest and Resuscitation
- Atrial Fibrillation Management and Outcomes
- Aortic Disease and Treatment Approaches
- Renal Transplantation Outcomes and Treatments
- Infective Endocarditis Diagnosis and Management
- Cardiac pacing and defibrillation studies
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Arrhythmias and Treatments
- Heart Failure Treatment and Management
- Tissue Engineering and Regenerative Medicine
- Cardiovascular Function and Risk Factors
- Congenital Heart Disease Studies
- Electrospun Nanofibers in Biomedical Applications
- Aortic aneurysm repair treatments
- Liver Disease and Transplantation
- COVID-19 Clinical Research Studies
- Infectious Aortic and Vascular Conditions
- Fuel Cells and Related Materials
- Cardiac Ischemia and Reperfusion
University of Houston
2019-2023
HCA Healthcare
2019-2022
Baylor College of Medicine
2018-2020
American Journal Experts (United States)
2020
University of Maryland, Baltimore
2013-2018
Drexel University
2017
Cardiovascular Research Foundation
2012-2016
University of Brescia
2014-2015
University of Maryland Medical Center
2013-2014
New York Hospital Queens
2005-2014
Neutrophil gelatinase–associated lipocalin (Ngal), also known as siderocalin, forms a complex with iron-binding siderophores (Ngal:siderophore:Fe). This converts renal progenitors into epithelial tubules. In this study, we tested the hypothesis that Ngal:siderophore:Fe protects adult kidney cells or accelerates their recovery from damage. Using mouse model of severe failure, ischemia-reperfusion injury, show single dose Ngal (10 μg), introduced during initial phase disease, dramatically and...
Many adult organs contain stem cells, which are pluripotent and involved in organ maintenance repair after injury. In situ, these cells often have a low cycling rate locate specialized regions (niches). To detect such the kidney, we administered pulse of nucleotide bromodeoxyuridine (BrdU) to rat mouse pups and, long (more than 2-month) chase, examined whether kidney contained population low-cycling cells. We found that BrdU-retaining were very sparse except renal papilla, where they...
Microarrays have been used extensively to profile transcriptome remodeling in failing human heart, although the genomic coverage provided is limited and fails provide a detailed picture of myocardial landscape. Here, we describe sequencing-based profiling, providing comprehensive analysis mRNA, microRNA (miRNA), long noncoding RNA (lncRNA) expression heart before after mechanical support with left ventricular (LV) assist device (LVAD). Deep sequencing isolated from paired nonischemic (NICM;...
Background— Heart failure is associated with impaired myocardial metabolism a shift from fatty acids to glucose use for ATP generation. We hypothesized that cardiac accumulation of toxic lipid intermediates inhibits insulin signaling in advanced heart and mechanical unloading the failing myocardium corrects metabolism. Methods Results— analyzed serum 61 patients (body mass index, 26.5±5.1 kg/m 2 ; age, 51±12 years) obtained during left ventricular assist device implantation at explantation...
As coronavirus disease 2019 (COVID-19) cases surge worldwide, an urgent need exists to enhance our understanding of the role extracorporeal membrane oxygenation (ECMO) in management severely ill patients with COVID-19 who develop acute respiratory and cardiac compromise refractory conventional therapy. The purpose this manuscript is review initial clinical experience 32 confirmed treated ECMO. A multi-institutional registry database was created utilized assess all were supported ECMO...
Patients with low ejection fraction (EF) are at a higher risk for postoperative complications and mortality. Our objective was to assess the effect of EF on clinical outcomes after coronary artery bypass grafting (CABG).We analyzed 55,515 patients from New York State database who underwent CABG between 1997 1999. were stratified into 1 4 groups: Group I (EF< or =20%), II (EF 21% 30%), III 31% 40%), IV (EF>40%). History previous myocardial infarction, renal failure, congestive heart failure...
Continuous-flow left ventricular assist devices (LVAD) are increasingly used for patients with end-stage heart failure (HF). We analyzed the effects of decompression by continuous-flow versus pulsatile-flow LVADs on myocardial structure and function in this population.Sixty-one who underwent LVAD implantation as bridge-to-transplant were (pulsatile-flow LVAD: group P, n=31; C, n=30). Serial echocardiograms, serum levels brain natriuretic peptide (BNP), extracellular matrix biomarkers (ECM)...
Purpose Management of acute type A aortic dissection (AAAD) is challenging and operative strategies are varied. We used the STS Adult Cardiac Surgery Database (STS ACSD) to describe contemporary surgical outcomes for AAAD. Methods Between July 2011 September 2012, 2982 patients with AAAD underwent operations at 640 centers in North America. Results In this cohort, median age was 60 years old, 66% were male, 80% had hypertension. The most common arterial cannulation included femoral (36%),...
With continuing improvements in medical devices and more than a decade since the 2006 United Network for Organ Sharing (UNOS) allocation policy, it is pertinent to assess survival among patients on heart transplantation waiting list, especially given recently approved 2018 UNOS policy.To outcomes transplant list during past 3 decades examine association of ventricular assist (VADs) policy with survival.A retrospective cross-sectional used database perform an analysis 95 323 candidates...
Background— Heart failure (HF) is characterized by inflammation, insulin resistance, and progressive catabolism. We hypothesized that patients with advanced HF also develop adipose tissue inflammation associated impaired adipokine signaling hemodynamic correction through implantation of ventricular assist devices (VADs) would reverse adipocyte activation correct in HF. Methods Results— Circulating insulin, adiponectin, leptin, resistin levels were measured 36 before after VAD 10 healthy...
The kidney papilla contains a population of cells with several characteristics adult stem cells, including the retention proliferation markers during long chase periods (i.e., they are label-retaining [LRCs]). To determine whether papillary LRCs generate new in normal kidney, we examined cell throughout and found that upper is site enhanced cycling. Using genetically modified mice conditionally expressed green fluorescence protein fused to histone 2B, observed proliferated only its part,...
Acid–base transport in the renal collecting tubule is mediated by two canonical cell types: β-intercalated secretes HCO 3 an apical Cl:HCO named pendrin and a basolateral vacuolar (V)-ATPase. Acid secretion α-intercalated cell, which has V-ATPase exchanger (kAE1). We previously suggested that β-cell converts to α-cell response acid feeding, process depended on deposition of extracellular matrix protein termed hensin (DMBT1). Here, we show deletion from intercalated cells results absence...
Neutrophil gelatinase–associated lipocalin (Ngal), also known as siderocalin, forms a complex with iron-binding siderophores (Ngal:siderophore:Fe). This converts renal progenitors into epithelial tubules. In this study, we tested the hypothesis that Ngal:siderophore:Fe protects adult kidney cells or accelerates their recovery from damage. Using mouse model of severe failure, ischemia-reperfusion injury, show single dose Ngal (10 μg), introduced during initial phase disease, dramatically and...
The objectives of this study are to determine risk factors associated with deep sternal wound infections (DSWIs) following cardiac surgery, and describe their impact on long-term survival. Data was obtained from a departmental database. Analysis included 7,978 consecutive patients who underwent surgery between 1997 2003. To identify for DSWI, regression analysis performed. probability scores logistic were used propensity 2 groups. Kaplan-Meier log-rank test Cox proportional hazard models...
The severe acute respiratory syndrome-CoV-2 is an emerging viral pathogen responsible for the global coronavirus disease 2019 pandemic resulting in significant human morbidity and mortality. Based on preliminary clinical reports, hypoxic failure complicated by distress syndrome leading cause of death. Further, septic shock, late-onset cardiac dysfunction, multiorgan system are also described as contributors to overall Although extracorporeal membrane oxygenation other modalities mechanical...
A subset of patients with coronavirus disease 2019 (COVID-19) develop profound respiratory failure and are treated via invasive mechanical ventilation (IMV). Of these, a smaller has severe gas exchange abnormalities that refractory to maximal levels IMV support. Extracorporeal membrane oxygenation (ECMO) been used successfully in these circumstances. However, using ECMO only after exposes the risks ventilator-induced lung injury. We report successful outcome setting COVID-19 absence an...