A5051630384- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Statistical Methods and Inference
- Cardiac Valve Diseases and Treatments
- Functional Brain Connectivity Studies
- Statistical Methods and Bayesian Inference
- Cardiac, Anesthesia and Surgical Outcomes
- Health, Environment, Cognitive Aging
- Ethics in Clinical Research
- Biomedical Ethics and Regulation
- Cancer survivorship and care
- Privacy-Preserving Technologies in Data
- Health Systems, Economic Evaluations, Quality of Life
- Advanced Causal Inference Techniques
- Biomedical and Engineering Education
- Infective Endocarditis Diagnosis and Management
- Aortic Disease and Treatment Approaches
- Lung Cancer Diagnosis and Treatment
- Advanced Drug Delivery Systems
- Sepsis Diagnosis and Treatment
- Blood Pressure and Hypertension Studies
- Medical Coding and Health Information
- Occupational exposure and asthma
- Diabetes Management and Education
- Sexual Assault and Victimization Studies
Biogen (United States)
2023-2025
University of Nevada, Las Vegas
2025
Sanofi (Canada)
2025
University of Vermont
2020-2024
McGill University
2014-2023
Birla Institute of Technology and Science, Pilani
2016-2023
Montreal Neurological Institute and Hospital
2020
Hamamatsu University School of Medicine
2020
University of British Columbia
2020
University of Oklahoma
2020
<h3>Importance</h3> Apolipoprotein E ε4 (<i>APOEε4</i>) is the single most important genetic risk factor for Alzheimer disease. While<i>APOEε4</i>is associated with increased amyloid-β burden, its association cerebral tau pathology has been controversial. <h3>Objective</h3> To determine whether<i>APOEε4</i>is medial temporal independently of amyloid-β, sex, clinical status, and age. <h3>Design, Setting, Participants</h3> This a study 2 cross-sectional cohorts volunteers who were cognitively...
Abstract Gold-standard diagnosis of Alzheimer’s disease (AD) relies on histopathological staging systems. Using the topographical information from [ 18 F]MK6240 tau positron-emission tomography (PET), we applied Braak system to 324 living individuals. We used PET-based stage model trajectories amyloid-β, phosphorylated (pTau) in cerebrospinal fluid (pTau 181 , pTau 217 231 and 235 ) plasma ), neurodegeneration cognitive symptoms. identified nonlinear AD biomarker corresponding spatial extent...
Importance The recent proliferation of phosphorylated tau (p-tau) biomarkers has raised questions about their preferential association with the hallmark pathologies Alzheimer disease (AD): amyloid-β plaques and neurofibrillary tangles. Objective To determine whether cerebrospinal fluid (CSF) plasma p-tau preferentially reflect cerebral β-amyloidosis or tangle aggregation measured positron emission tomography (PET). Design, Setting, Participants This was a cross-sectional study 2...
<h3>Importance</h3> Prompt bystander cardiopulmonary resuscitation (CPR) improves the likelihood of surviving an out-of-hospital cardiac arrest. Large regional variations in survival after arrest have been noted. <h3>Objectives</h3> To determine whether county-level rates CPR training exist across United States and factors associated with low US counties. <h3>Design, Setting, Participants</h3> We used a cross-sectional ecologic study design to analyze all counties from July 1, 2010, through...
Purpose Management of acute type A aortic dissection (AAAD) is challenging and operative strategies are varied. We used the STS Adult Cardiac Surgery Database (STS ACSD) to describe contemporary surgical outcomes for AAAD. Methods Between July 2011 September 2012, 2982 patients with AAAD underwent operations at 640 centers in North America. Results In this cohort, median age was 60 years old, 66% were male, 80% had hypertension. The most common arterial cannulation included femoral (36%),...
Amyloid-β deposition into plaques is a pathologic hallmark of Alzheimer disease appearing years before the onset symptoms. Although cerebral amyloid-β occurs on continuum, dichotomization positive and negative groups has advantages for diagnosis, clinical management, population enrichment trials. <sup>18</sup>F-AZD4694 (also known as <sup>18</sup>F-NAV4694) an imaging ligand with high affinity plaques. Despite being used in multiple academic centers, no studies have assessed quantitative...
APOEε4 is the most well-established genetic risk factor for sporadic Alzheimer's disease and associated with cerebral amyloid-β. However, association between tau pathology, other major proteinopathy of disease, has been controversial. Here, we sought to determine whether relationship pathology determined by local interactions We examined three independent samples cognitively unimpaired, mild cognitive impairment subjects: (1) 211 participants who underwent tau-PET [18F]MK6240 amyloid-PET...
Importance Amyloid-related imaging abnormalities (ARIA) are brain magnetic resonance (MRI) findings associated with the use of amyloid-β–directed monoclonal antibody therapies in Alzheimer disease (AD). ARIA monitoring is important to inform treatment dosing decisions and might be improved through assistive software. Objective To assess clinical performance an artificial intelligence (AI)–based software tool for assisting radiological interpretation MRI scans patients monitored ARIA. Design,...
Competing risks arise naturally in time-to-event studies. In this article, we propose time-dependent accuracy measures for a marker when have censored survival times and competing risks. Time-dependent versions of sensitivity or true positive (TP) fraction correspond to consideration either cumulative (or prevalent) cases that accrue over fixed time period, alternatively incident are observed among event-free subjects at any select time. (dynamic) specificity (1-false (FP)) can be based on...
To assess the frequency of biologically defined Alzheimer disease (AD) in relation to age, sex, APOE ε4, and clinical diagnosis a prospective cohort study evaluated with amyloid-PET tau-PET.We assessed cognitively unimpaired (CU) elderly (n = 166), patients amnestic mild cognitive impairment 77), probable AD dementia 62) who underwent evaluation by specialists neuropsychologists addition [18F]AZD4694 tau-PET [18F]MK6240. Individuals were grouped according their biomarker profile. Positive...
Abstract Background To investigate the association of plasma pTau181, assessed with a new immunoassay, neurodegeneration white matter and gray cross-sectionally longitudinally, in aging Alzheimer’s disease. Methods Observational data was obtained from Disease Neuroimaging Initiative, which participants underwent assessment magnetic resonance imaging. Based on their clinical diagnosis, were classified as cognitively unimpaired impaired. Linear regressions linear mixed-effect models used to...
Abstract Alzheimer’s disease is the leading cause of dementia worldwide and characterized by a long preclinical phase in which amyloid-β tau accumulate absence cognitive decline. In vivo biomarkers for are expensive, invasive inaccessible, yet critical accurate diagnosis patient management. Recent ultrasensitive methods to measure plasma phosphorylated 181 (p-tau181) display strong correlations with positron emission tomography, p-tau181 CSF, pathology at autopsy. The clinical utility...
Alzheimer’s disease (AD) phenotypes might result from differences in selective vulnerability. Evidence preclinical models suggests that tau pathology has cell-to-cell propagation properties. Therefore, here, we tested the framework amnestic, visuospatial, language, and behavioral/dysexecutive of AD. We report each AD phenotype is associated with a distinct network-specific pattern aggregation, where aggregation concentrated brain network hubs. In all phenotypes, regional load could be...
A major biomedical goal associated with evaluating a candidate biomarker or developing predictive model score for event-time outcomes is to accurately distinguish between incident cases from the controls surviving beyond t throughout entire study period. Extensions of standard binary classification measures like time-dependent sensitivity, specificity, and receiver operating characteristic (ROC) curves have been developed in this context (Heagerty, P. J., others, 2000. Time-dependent ROC...
<h3>Objective</h3> To determine the associations between amyloid-PET, tau-PET, and atrophy with behavioral/dysexecutive presentation of Alzheimer disease (AD), how these differ from amnestic AD, they correlate to clinical symptoms. <h3>Methods</h3> We assessed 15 patients AD recruited a tertiary care memory clinic, all whom had biologically defined AD. They were compared 25 severity– age-matched group 131 cognitively unimpaired (CU) elderly individuals. All participants evaluated amyloid-PET...
Aortic root surgery is transitioning to aortic valve sparing (AVS), but little known about the relative early outcomes of AVS versus composite graft-valve replacement (CVR). This study assessed mortality differences for CVR guide future practice decisions. From January 2000 June 2011, 31 747 patients had with (n = 3585; 11%) or 28 162; 89%). The cohort Overall was divided into two subgroups: high-risk 20 356; 6% AVS) having age >75 years, endocarditis, stenosis, dialysis, multiple valves,...
Introduction Implementation data for digital unsupervised HIV self-testing (HIVST) are sparse. We evaluated the impact of an app-based, personalised, oral HIVST program offered by healthcare workers in Western Cape, South Africa. Methods In a quasirandomised study (n=3095), we recruited consenting adults with undiagnosed infection from township clinics. To arm participants (n=1535), choice offsite (home, office or kiosk based), (n=962), onsite, clinic-based, supervised (n=573) 24/7 linkages...