A5040150087- Temporomandibular Joint Disorders
- Musculoskeletal pain and rehabilitation
- Botulinum Toxin and Related Neurological Disorders
- Pain Mechanisms and Treatments
- Oral microbiology and periodontitis research
- Dental Health and Care Utilization
- Myofascial pain diagnosis and treatment
- Dental Radiography and Imaging
- Dental Anxiety and Anesthesia Techniques
- Dental Research and COVID-19
- Salivary Gland Disorders and Functions
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Pain Management and Placebo Effect
- Obstructive Sleep Apnea Research
- Trigeminal Neuralgia and Treatments
- Anesthesia and Pain Management
- Pain Management and Opioid Use
- Migraine and Headache Studies
- Orthodontics and Dentofacial Orthopedics
- Heme Oxygenase-1 and Carbon Monoxide
- Oropharyngeal Anatomy and Pathologies
- Oral health in cancer treatment
- Parkinson's Disease Mechanisms and Treatments
- Head and Neck Cancer Studies
- Dental materials and restorations
Jewish General Hospital
2015-2024
McGill University
2015-2024
Montreal General Hospital
2015-2022
McGill University Health Centre
2010-2015
University of Minnesota
2007-2013
University of Minnesota System
2011
University of North Carolina at Chapel Hill
2011
Scleroderma Foundation
2010
Université de Montréal
1998-2010
Twin Cities Orthopedics
2010
Neuropathic pain (NeP), generated by disorders of the peripheral and central nervous system, can be particularly severe disabling. Prevalence estimates indicate that 2% to 3% population in developed world suffer from NeP, which suggests up one million Canadians have this disabling condition. Evidence‐based guidelines for pharmacological management NeP are therefore urgently needed. Randomized, controlled trials, systematic reviews existing focusing on were evaluated at a consensus meeting....
Neuropathic pain (NeP), redefined as caused by a lesion or disease of the somatosensory system, is disabling condition that affects approximately two million Canadians.To review randomized controlled trials (RCTs) and systematic reviews related to pharmacological management NeP develop revised evidence-based consensus statement on its management.RCTs, existing guidelines were evaluated at meeting in May 2012 updated until September 2013. Medications recommended if their analgesic efficacy...
This case-control study was designed to investigate the contributing factors for chronic masticatory myofascial pain (MFP). Eighty-three patients with MFP, selected from dental clinics of Jewish General and Montreal Hospitals, Montreal, Canada, 100 concurrent controls only at first clinic, participated in this study. The association MFP evaluated bruxism, head-neck trauma, psychological (symptom check list 90 revised questionnaire, SCL-90R) sociodemographic characteristics by using...
Although most cases of temporomandibular muscle and joint disorders (TMJD) are mild self-limiting, about 10% TMJD patients develop severe associated with chronic pain disability. It has been suggested that depression catastrophizing contributes to chronicity. This article assesses the effects on clinically significant (Graded Chronic Pain Scale [GCPS] II-IV). Four hundred eighty participants, recruited from Minneapolis/St. Paul area through media advertisements local dentists, received...
In Brief BACKGROUND: Preoperative glucocorticoids reduce postoperative nausea but may also improve analgesia and decrease opioid consumption. METHODS: Fifty consecutive patients undergoing elective, unilateral, primary total hip arthroplasty under spinal anesthesia with propofol sedation received in a randomized, double-blind, placebo-controlled manner either 40 mg of dexamethasone or saline placebo IV before the start surgery. patient-controlled morphine, ibuprofen 400 po q6 h acetaminophen...
The present study assessed the role of pain and pain-related psychological variables in persistence post-traumatic stress symptoms following whiplash injury. Individuals (N=112) with injuries who had been admitted to a standardized multidisciplinary rehabilitation program were asked complete measures pain, symptoms, physical function at three different points during their treatment program. findings are consistent previous research showing that indicators injury severity such as reduced...
Abstract Background Parkinson's disease (PD) is the most common movement disorder among adults, affecting 2% of world population older than 65 years age. No diagnostic biomarker for routine use in clinical settings currently exists. Dysregulation microRNAs (miRNAs) has been implicated various neurodegenerative conditions, including PD. Distinct miRNAs have demonstrated to be involved regulation α‐synuclein, a key player PD pathogenesis; miR‐153 and miR‐223 are downregulated brain serum...
Temporomandibular pain disorder (TMD) is a common condition in the face. People with TMD report multiple comorbidities. The presence of fibromyalgia and migraine people associated an increase intensity duration. However, data on relationship between increasing number comorbidities are rare. aims this study were: firstly to evaluate extent which duration; secondly specific sample included 180 seeking treatment at Boston Montreal clinics. was diagnosed using Research Diagnostic Criteria for...
ABSTRACT Background and Hypothesis To date, there are no chemical analytes, including biochemical indices of oxidative stress, metabolites α‐synuclein protein, differential protein expression patterns on proteomic profiling, for use in clinics as a diagnostic biomarker idiopathic PD. Objectives Heme oxygenase‐1 has been implicated the pathogenesis The objective this study is to ascertain whether salivary heme may serve early Methods Fifty‐eight PD patients 59 non‐neurological disease...
Summary Oxidative stress is involved in the pathogenesis of many conditions and caused by free radicals concentrations that overwhelm natural scavenging mechanisms cause pain inflammation. This investigation sought to determine whether from temporomandibular disorders was associated with increased oxidative as measured biomarkers saliva serum. Both salivary serum levels including 8-hydroxydeoxyguanosine, malondialdehyde total antioxidant status were compared patients mild severe TMJD healthy...