A5039058918- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Renal Transplantation Outcomes and Treatments
- Liver Disease Diagnosis and Treatment
- Transplantation: Methods and Outcomes
- Organ Donation and Transplantation
- Polyomavirus and related diseases
- Hepatocellular Carcinoma Treatment and Prognosis
- Bariatric Surgery and Outcomes
- Viral-associated cancers and disorders
- Pancreatic function and diabetes
- Liver physiology and pathology
- T-cell and B-cell Immunology
- Extracellular vesicles in disease
- Pancreatic and Hepatic Oncology Research
- Immune Cell Function and Interaction
- Cytomegalovirus and herpesvirus research
- Body Contouring and Surgery
- Hepatitis B Virus Studies
- Cardiac Valve Diseases and Treatments
- Intraperitoneal and Appendiceal Malignancies
- Immunotherapy and Immune Responses
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Diseases and Immunity
- Cancer-related molecular mechanisms research
University of Wisconsin–Madison
2019-2025
UW Health University Hospital
2020-2025
Highland Community College - Illinois
2024
University of Alberta
2011-2022
University of Wisconsin Carbone Cancer Center
2021-2022
University of Wisconsin Health
2021
Medical University of Vienna
2020
Ospedale regionale di Lugano
2020
University of Toronto
2017-2018
Toronto General Hospital
2017-2018
To compare conventional low-temperature storage of transplant donor livers [static cold (SCS)] with the organs at physiological body temperature [normothermic machine perfusion (NMP)].
To fully harness mesenchymal-stromal-cells (MSCs)' benefits during Normothermic Machine Perfusion (NMP), we developed an advanced NMP platform coupled with a MSC-bioreactor and investigated its bio-molecular effects clinical feasibility using rat porcine models. The study involved three work packages: 1) Development (n = 5): MSC-bioreactors were subjected to 4 h-liverless perfusion; 2) Rat model 10): livers perfused for h on the MSC-bioreactor-circuit or standard platform; 3) Porcine 6):...
Patients undergoing evaluation for solid organ transplantation (SOT) frequently have a history of malignancy. Only patients with treated cancer are considered SOT but the benefits need to be balanced against risk tumor recurrence, taking into consideration potential effects immunosuppression. Prior guidelines on timing transplant in prior malignancy do not account current staging, disease biology, or advances treatments. To update these recommendations, American Society Transplantation (AST)...
De novo malignancies (DNMs) following liver transplantation (LT) have been reported as 1 of the major causes late mortality, being most common cause death in second decade after LT. The overall incidence DNMs is to be range 3.1% 14.4%, and 2- 3-fold higher transplant recipients than age- sex-matched healthy controls. Long-term immunosuppressive therapy, which key maintaining host tolerance achieving good long-term outcomes, known contribute a risk DNMs. However, type DNM also depends on...
<h3>Background:</h3> Worldwide, more than 1.7 billion individuals may be classified as overweight and are in need of appropriate medical surgical treatments. The primary goal a comprehensive weight management program is to produce sustainable loss. However, for such effective, the patient must complete it. We analyzed attrition rates predictors within publicly funded, multi-disciplinary adult program. <h3>Methods:</h3> retrospectively reviewed charts from an urban multidisciplinary clinic...
Background Islet transplantation is a recognized treatment option for select patients with type I diabetes mellitus. However, islet infusions from multiple donors are often required to achieve insulin independence. Ideally, independence would be achieved routinely only single donor. Identification of factors associated after single-donor may help recipient-donor combinations the highest probability success. Methods Subjects undergoing at center (Edmonton, Canada) between March 1999 and...
Hypothesis: A local multiorgan donor pancreas procurement program can provide a source for optimized isolation of purified viable islets transplantation into patients with type 1 diabetes mellitus receiving best medical therapy.Design: Prospective before-after cohort study.Setting: Tertiary referral center.Patients: Glycemic control was assessed in 10 diabetes-induced renal dysfunction who were enrolled therapy and then crossed over to islet transplantation.Interventions: Thirty human...
Dysregulation of expression functional genes and pathways plays critical roles in the etiology progression hepatocellular carcinoma (HCC). Next generation-based RNA sequencing (RNA-seq) offers unparalleled power to comprehensively characterize HCC at whole transcriptome level. In this study, 17 fresh-frozen samples with paired non-neoplastic liver tissue from Caucasian patients undergoing resection or transplantation were used for RNA-seq analysis. Pairwise differential analysis data was...
Hepatocellular carcinoma (HCC) is one of the most fatal cancers in world. There an urgent need to understand molecular background HCC facilitate identification biomarkers and discover effective therapeutic targets. Published transcriptomic studies have reported a large number genes that are individually significant for HCC. However, reliable remain be determined. In this study, built on max-linear competing risk factor models, we developed machine learning analytical framework analyze data...
Basic & translational research (B&TR) in liver transplantation (LT) underwent considerable changes and shifts over the past decade. To capture current landscape future potential of B&TR LT, we conducted an online survey within International Liver Transplantation Society (ILTS) community. The aimed to collect comprehensive data on respondents’ characteristics, qualifications, experiences, activities, providing present state directions LT. Between October 2023 January 2024,...
ABSTRACT Background Cytomegalovirus (CMV) drives negative outcomes after liver transplant (LT), with patients having high‐risk serostatuses (D+/R−) being especially vulnerable. While valganciclovir (VGC) remains the standard‐of‐care, letermovir (LTV) represents a promising potential in LT, given reduced myelosuppression. Methods Adult receiving an LT CMV serostatus June 1, 2021–June 6, 2024 were evaluated. Patients included standard‐of‐care (SOC) or LTV cohort based on de novo antiviral...
<title>Abstract</title> <bold>Background:</bold> Chronic liver disease is a major health concern, but sex-specific differences in its pathophysiology remain unclear. Preclinical studies have predominantly used male animals, limiting findings' relevance to both sexes. This project aimed explore sex cirrhosis and portal hypertension (PH) rats, find similarities human samples for translational relevance. <bold>Methods:</bold> Advanced chronic (ACLD) was induced female Sprague-Dawley rats using...