A5054481572- Organ Donation and Transplantation
- Organ Transplantation Techniques and Outcomes
- Palliative Care and End-of-Life Issues
- Renal Transplantation Outcomes and Treatments
- Grief, Bereavement, and Mental Health
- Renal and Vascular Pathologies
- Liver Disease and Transplantation
- Transplantation: Methods and Outcomes
- Ethics in Clinical Research
- Blood donation and transfusion practices
- Biomedical Ethics and Regulation
- Pharmaceutical industry and healthcare
- Patient Dignity and Privacy
- Reproductive Health and Technologies
- Hematopoietic Stem Cell Transplantation
- Geriatric Care and Nursing Homes
- CAR-T cell therapy research
- Neuroethics, Human Enhancement, Biomedical Innovations
- Health Systems, Economic Evaluations, Quality of Life
- Sharing Economy and Platforms
- Optimism, Hope, and Well-being
- Epilepsy research and treatment
- Meta-analysis and systematic reviews
- Polyomavirus and related diseases
- Metabolism and Genetic Disorders
University of Wisconsin–Madison
2022-2025
University of California, San Francisco
2020-2022
Yale University
2013-2021
Miltenyi Biotec (Germany)
2018-2019
Northwestern University
2016-2018
University of Pennsylvania
2016-2018
Yale New Haven Hospital
2016
Greenwall Foundation
2016
Harvard University Press
2009
Massachusetts General Hospital
2008-2009
Despite effective antiviral treatment, hundreds of kidneys from deceased donors with hepatitis C virus (HCV) are discarded annually. Little is known about the determinants willingness to accept HCV-infected among HCV-negative patients.At 2 centers, 189 patients undergoing initial or reevaluation for transplant made 12 hypothetical decisions accepting in which we systematically varied expected HCV cure rate, allograft quality, and wait time an uninfected kidney.Only 29% participants would...
Living kidney donors are often excluded from the shared decision making and patient-centered models that advocated in medical practice. Thresholds for acceptable risk vary between transplant centers, clinicians donors. Although donor selection committees commonly focus on risks, potential also consider nonmedical risks burdens, which may alter their assessment of an level risk. Thus, centers encounter ethical tensions nonmaleficence respect autonomy. A donor-centered model reconciliation...
Abstract Introduction In October 2021, the American Society of Transplantation (AST) hosted a virtual consensus conference aimed at identifying and addressing barriers to broader, safe expansion living donor liver transplantation (LDLT) throughout United States (US). Methods A multidisciplinary group LDLT experts convened address issues related financial implications on donor, transplant center crisis management, regulatory oversight policies, ethical considerations by assessing relative...
Living donor liver transplantation (LDLT) is a promising option for mitigating the deceased organ shortage and reducing waitlist mortality. Despite excellent outcomes data supporting expanding candidate indications LDLT, broader uptake throughout United States has yet to occur.In response this, American Society of Transplantation hosted virtual consensus conference (October 18-19, 2021), bringing together relevant experts with aim identifying barriers implementation making recommendations...
Tickborne infections are challenging to diagnose, particularly among solid organ transplant recipients. We report a US case of donor-derived ehrlichiosis from living kidney donation that highlights how screening for donors may miss tickborne infections. Clinicians should consider the epidemiology donor when donations and evaluating recipients infection.
New approaches to address the kidney scarcity in United States are urgently needed. The greatest potential source of kidneys is from living donors. Proposals offer financial incentives increase donation rates remain highly controversial. Despite repeated calls for a pilot study assess impact compensation on rates, many fear that will exploit vulnerable individuals and cast field transplantation negative public light, ultimately reducing rates. This paper provides an ethical justification...
A better understanding of the consequences being turned down for living kidney donation could help transplant professionals to counsel individuals considering donation.In this exploratory study, we used survey instruments and qualitative interviews characterize nonmedical outcomes among between July 1, 2010 December 31, 2013. We assembled a comparator group donors.Among 83 turned-down donors with contact information at single center, 43 (52%) participated in study (median age 53 years; 53%...
Objectives: To report the attitudes and opinions of subjects in US clinical trials about whether or not, why, they should receive post-trial access (PTA) to trial drug, care information. Design: Focus groups, short self-administered questionnaires. Setting: Boston, Dallas, Detroit, Oklahoma City. Participants: Current recent trials, primarily for chronic diseases. Results: 93 individuals participated 10 focus groups. Many thought researchers, sponsors, health insurers others share...
In this article, we provide an ethical analysis of the first porcine cardiac xenotransplant, performed in Maryland, USA early 2022. David Bennett was offered experimental procedure after he deemed ineligible for human heart transplantation and mechanical circulatory support, based on a history non-compliance. It reported that Mr Bennett’s previous instances non-compliance were medically non-life-threatening conditions years earlier, where risks not as high. We argue that, case, different...
Ethicists and guidelines have suggested that potential living kidney donors who withdraw from evaluation be offered an 'alibi.' We sought to determine what are told about their ability opt out, alibi availability postwithdrawal confidentiality. reviewed 148 consent forms for donor US transplant centres performed >5 transplants in 2010-2011 (response rate 87%). found while 98% of used indicated the could withdraw, only 21% these documents alibi. Another 23% centres' team would willing inform...
Transplant professionals recognize that the long-term follow-up of living organ donors is a priority, yet there has been no implemented solution to this problem. This critical gap essential, because transplant field now emphasizing donation as means address shortage. We detail our donor initiative, which sets several priorities we fundamental persons who have donated organs at center. intervention attempts mitigate and center factors are known contribute lack follow-up. Beyond that, goals...
To assess what individuals in low-income countries perceive as benefits and harms of population-based HIV/STD research.A total 811 research participants, decliners, community opinion leaders the Rakai District, Uganda were surveyed. Types personal harms, well rates reporting great benefit assessed.Using logistic regression, demographic characteristics, participant leader status, use Health Sciences Program (RHSP) services, perceived effects entered predictors reported benefit.Most...
Background Sensitization and activity status are associated with kidney transplant waitlist mortality. Unknown is how changes in these covariates after listing impact outcomes. Methods Two cohorts were created from the OPTN (Organ Procurement Transplantation Network) database, one pre-KAS (new allocation system) (10/01/2009-12/04/2013, n = 97,793) post-KAS (12/04/2014-06/17/2015, 13,113). Multi-state modeling provides transition probabilities between intermediate states (CPRA...
Understanding why individuals opt out of living donation is crucial to enhancing protections for all donors and identify modifiable barriers donation. We developed an ethical approach conducting research on who opted kidney applied it in a small-scale qualitative study at one US transplant centre. The seven participants (64% response rate) had varied reasons opting out, the most prominent which was concern about financial burden from lost wages during postoperative period. Several reported...
<h3>Rationale & Objective</h3> Enhanced informed consent tools improve patient engagement. A novel visual aid measured potential donors' risk tolerance to postdonation kidney failure and assessed if the closeness of relationship intended recipient altered willingness accept risk. <h3>Study Design</h3> Cross-sectional analysis donor evaluations at time enrollment into a longitudinal mixed-methods study between November 2014 February 2016. <h3>Setting Participants</h3> Three US transplant...