A5064626231- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- HIV/AIDS drug development and treatment
- Polyomavirus and related diseases
- Transplantation: Methods and Outcomes
- Renal Diseases and Glomerulopathies
- Nonmelanoma Skin Cancer Studies
- Cytomegalovirus and herpesvirus research
- Pharmacological Effects and Toxicity Studies
- Organ and Tissue Transplantation Research
- Hepatitis C virus research
- Dialysis and Renal Disease Management
- HIV/AIDS Research and Interventions
- Cutaneous lymphoproliferative disorders research
- Neurological Complications and Syndromes
- Liver Disease and Transplantation
- Mycobacterium research and diagnosis
- Parathyroid Disorders and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Complement system in diseases
- Muscle and Compartmental Disorders
- HIV-related health complications and treatments
- Medical Imaging and Pathology Studies
- Immunotherapy and Immune Responses
University of Virginia
2017-2025
University of Virginia Health System
2017-2024
Drexel University
2011-2018
Hahnemann University Hospital
2016
University of Pennsylvania
2000-2013
Hospital of the University of Pennsylvania
2004-2010
Gülhane Askerî Tıp Akademisi
2005
Szczecin Academy of Arts
2005
Hospital Universitario Ramón y Cajal
2005
Medical University of Silesia
2005
Although posttransplantation anemia (PTA) is common in the mycophenolate mofetil era, its impact on patient survival unknown. This retrospective cohort study characterized factors that are associated with PTA 12 mo after transplantation mofetil-treated kidney recipients and explored whether 12-mo affects outcomes. The records of 626 were examined for presence (hemoglobin <12 g/dl). Multivariate regression models, fit covariates had unadjusted relationships, investigated both risk contributes...
Cytotoxic T lymphocyte antigen (CTLA)-4 plays an essential role in immunologic homeostasis. How this negative regulator of cell activation executes its functions has remained controversial. We now provide evidence that CTLA-4 mediates a cell-intrinsic counterbalance to restrict the clonal expansion proliferating CD4+ cells. The regulation expression and function ensures that, after ∼3 divisions expansion, most progeny will succumb either proliferative arrest or death over ensuing three...
Low physical activity (PA) has been associated with higher rates of cardiovascular disease (CVD) and mortality in the general population. Despite benefits kidney transplantation, transplant recipients (KTRs) remain at elevated risk for CVD compared to individuals without disease.A prospective cohort 507 adult KTRs from three academic centers completed Physical Activity Scale Elderly (PASE) transplantation. PASE scores were divided into tertiles.PA was lower older age, history CVD, smoking,...
Organ transplant recipients have a higher incidence of skin cancer. This risk is magnified over time and with continued exposure to immunosuppression. Skin cancer in nonwhite patients associated greater morbidity mortality owing diagnosis at more advanced stage, which suggests that organ are even risk.To describe demographic clinical factors the recipients.We performed retrospective medical record review who were (154 white 259 [black, Asian, Hispanic, Pacific Islander]) seen from November...
Cytomegalovirus (CMV) infection is associated with reduced graft and patient survival among kidney recipients. The highest risk of CMV occurs in CMV-naive recipients kidneys from seropositive donors (D+/R-). Optimal prophylaxis not established. This prospective cohort study compared the safety efficacy 12 versus 24 weeks oral ganciclovir.We prospectively administered ganciclovir to 31 D+/R- control group comprised 39 patients transplanted immediately preceding era who received a 12-week...
Despite clear consensus and strong recommendations, vaccination rates of kidney transplant (KT) recipients have remained below targets. As is most effective if it given prior to transplantation the initiation immunosuppression, patients should ideally their status assessed optimized in pre-transplant period. We performed a retrospective chart review characterize factors associated with gaps single-center population waitlisted being evaluated for transplantation. 362 KT patients....
Dapsone, used for prevention of Pneumocystis jirovecii infections, has been reported to cause hemolytic anemia and methemoglobinemia; its tolerability in solid organ transplant recipients is not well described. We investigated dapsone-related adverse events patients undergoing transplantation from 1999 2004. Transplant providers identified the investigators who then reviewed patients' hospital outpatient records. Sixteen fit case definitions (n = 11) or methemoglobinemia 5). Median time...
Recent reports have suggested an association of antiDP antibodies with allograft rejection and graft loss, in both primary kidney transplant recipients re-grafts [1–3]. However, most cases, it is difficult to separate the effects anti-HLA-DP from other anti-HLA class I II antibodies. Among non-conserved haplotypes, HLA-DP allele mismatches occur despite matching for HLA loci, because lack linkage disequilibrium between DP loci [4]
This is a single institution report of the incidence combined acute antibody-mediated rejection (ABMR) + cellular (ACR) [mixed rejection] in HIV (+) kidney transplant recipients.We prospectively enrolled 92 patients who received between 2001 and 2009. There were three cohorts: no [n=26], ACR [n=53], mixed rejections (ABMR ACR) [n=13]. Immunosuppression comprised basiliximab, cyclosporine, sirolimus, steroid minimization. Fisher exact tests for categorical variables, t test continuous...
Background Several treatment options exist for kidney transplant patients with tertiary hyperparathyroidism. However, the decision to endorse observation (OBS), medical therapy, or parathyroidectomy (PTX) remains controversial. Methods We performed a retrospective cohort study of hyperparathyroidism at single institution over 7-year period. Patients were classified by mode: OBS, therapy cinacalcet (CIN), PTX. Descriptive statistics performed. Serum calcium levels and change in serum...
Squamous cell carcinoma (SCC) is the most common skin cancer diagnosed in solid organ transplant recipients (OTRs) and confers significant mortality. The development of SCC genital region elevated nonwhite OTRs. Viral induction, specifically human papillomavirus (HPV), hypothesized to play a role pathophysiology these lesions.To assess prevalence types lesions observed OTRs.This retrospective review included 496 OTRs who underwent full examination from November 1, 2011, April 28, 2017, at an...
The risk for skin cancer has been well characterized in white organ transplant recipients (OTRs); however, most patients on the waiting list United States are nonwhite. Little is known about cutaneous disease and this OTR population.To compare incidence of between nonwhite OTRs.This retrospective review medical records included 412 OTRs treated from November 1, 2011, through April 22, 2016, at an academic referral center. Prevalence characteristics were compared 154 258 (ie, Asian, Hispanic,...
Tickborne infections are challenging to diagnose, particularly among solid organ transplant recipients. We report a US case of donor-derived ehrlichiosis from living kidney donation that highlights how screening for donors may miss tickborne infections. Clinicians should consider the epidemiology donor when donations and evaluating recipients infection.
To describe a novel case of donor-derived scedosporium infection following kidney transplantation presenting as endogenous endophthalmitis. A 69 year-old male presented with right eye pain and redness for 3 days deceased donor transplant one month prior. Initial exam showed counting fingers vision, 4+ anterior chamber cell, hypopyon, dense vitritis, large white macular lesion. vitreous tap inject was performed intravitreal vancomycin, ceftazidime, voriconazole. The patient admitted to the...
Polyomavirus (primarily BK virus [BKV]) infection is an important cause of chronic renal dysfunction in transplant recipients, but its possible contribution to non-renal solid organ (NRSOT) recipients has not been fully explored.We performed a prospective, cross-sectional study consecutive NRSOT with unexplained at least 3 months duration. Medical records were reviewed, and polymerase chain reaction was used amplify BKV-specific sequences from serum urine samples. The potential associations...
Organ transplant recipients (OTRs) are at increased risk of cutaneous malignancy. Skin disorders in OTRs color (OTRoC) have rarely been systematically assessed. We aimed to ascertain the burden skin disease encountered OTRoC by prospectively collecting data from attending 2 posttransplant surveillance clinics: 1 London, UK and Philadelphia, USA. Retrospective review all dermatological diagnoses was performed. Data 1766 were analyzed: 1024 (58%) white, 376 (21%) black, 261 (15%) Asian, 57...
The ancient dream of successful organ transplantation was finally realized 50 yr ago, on December 23, 1954, at the Peter Bent Brigham Hospital in Boston. Over subsequent half century, separate disciplines clinical and transplant immunology have made remarkable progress.
Chronic kidney disease among prior heart transplant recipients is a growing problem that likely to place an increased demand on limited supply of allografts. Allocation the resource kidneys for transplantation requires consideration demands fair distribution and optimizing patient graft survival. The aim this study was compare outcomes after (KAH, n=456) with in other clinical settings.A retrospective cohort using United Network Organ Sharing registry data (1995-2008) performed comparing...
Human immunodeficiency virus (HIV)-infected patients have excellent outcomes following kidney transplantation (KT) but still might face barriers in the evaluation and listing process. The aim of this study was to characterize patient population, referral patterns, HIV-infected who present for KT evaluation. We performed a single-center retrospective cohort were evaluated KT. primary outcome time determination eligibility Between 2011 2015, 105 Of patients, 73 listed by end period. For those...