A5052821189- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Orthopaedic implants and arthroplasty
- Management of metastatic bone disease
- COVID-19 and healthcare impacts
- Total Knee Arthroplasty Outcomes
- Orthopedic Infections and Treatments
- Musculoskeletal synovial abnormalities and treatments
- Reconstructive Surgery and Microvascular Techniques
- Surgical site infection prevention
- Cardiac, Anesthesia and Surgical Outcomes
- Trauma and Emergency Care Studies
- Tumors and Oncological Cases
- Bone health and treatments
- Oral and Maxillofacial Pathology
- CAR-T cell therapy research
- Cancer Research and Treatments
- Shoulder Injury and Treatment
- Shoulder and Clavicle Injuries
- Soft tissue tumor case studies
- Bone fractures and treatments
- Vascular Tumors and Angiosarcomas
- Cardiac tumors and thrombi
- Spine and Intervertebral Disc Pathology
- Cancer, Stress, Anesthesia, and Immune Response
Duke University
2015-2024
Duke University Hospital
2018-2024
Duke Medical Center
2015-2024
Charité - Universitätsmedizin Berlin
2022
University of Birmingham
2020-2021
NIHR Birmingham Biomedical Research Centre
2021
Duke Cancer Institute
2021
Yorkshire Cancer Research
2021
Urology Foundation
2021
Association for Cancer Surgery
2021
Abstract Background Historically, amputation was the primary surgical treatment for osteosarcoma of extremities; however, with advancements in techniques and chemotherapies limb salvage has replaced as dominant paradigm. This study assessed type resection chosen patients twenty-first century. Methods Utilizing largest registry osteosarcoma, National Cancer Database (NCDB), we retrospectively analyzed high grade extremities from 2004 through 2015. Differences between undergoing are described....
In the United States, race and socioeconomic status are well known predictors of adverse outcomes in several different cancers. Existing evidence suggests that may impact survival soft tissue sarcoma (STS). We investigated National Cancer Database (NCDB), which contains medical variables largest patient registry to date. Our goal was determine race, ethnicity on patients with extremities (STS-E).We retrospectively analyzed 14,067 STS-E NCDB from 1998 through 2012. Patients were stratified...
Aims Local recurrence remains a challenging and common problem following curettage joint-sparing surgery for giant cell tumour of bone (GCTB). We previously reported 15% local rate at median follow-up 30 months in 20 patients with high-risk GCTB treated neoadjuvant Denosumab. The aim this study was to determine if initial favourable outcome the use Denosumab maintained longer follow-up. Methods Patients limb considered unsuccessful joint salvage, due minimal periarticular subchondral bone,...
Purpose. Recently, the association between ATRX and a more aggressive sarcoma phenotype has been shown. We performed retrospective study of sarcomas from an individual institution to evaluate as prognosticator in soft tissue sarcoma. Experimental Design. 128 were collected single stained for ATRX. The prognostic significance these markers was evaluated smaller cohort primary (n = 68). Kaplan–Meier curves created univariate analysis, Cox regression utilized multivariate analysis. Results....
Introduction . Extremity lipomas and well-differentiated liposarcomas (WDLs) are difficult to distinguish on MR imaging. We sought evaluate the accuracy of MRI interpretation using MDM2 amplification, via fluorescence in-situ hybridization (FISH), as gold standard for pathologic diagnosis. Furthermore, we aimed investigate utility a diagnostic formula proposed in literature. Methods retrospectively collected 49 patients with or WDLs utilizing Four expert readers interpreted each patient’s...
In orthopedic oncology, the implant of a megaprosthetic device is standard care after large-scale tumor resection involving segmental removal bone. Infection remains leading cause failure, often resulting in major morbidity. Perioperative antibiotic practices for reconstructions are not standardized and based on guidelines conventional joint arthroplasties. This study aims to evaluate efficacy current prophylactic strategies reconstructions. We conducted retrospective review performed at...
Orthopedic procedures often require removing bone or pathological tissue, with traditional methods involving instruments like curettes and rongeurs. However, these can be time-consuming lead to increased blood loss. To mitigate side effects, vacuum-assisted tools have been developed aid in tissue removal. These devices enable surgeons suction without discarding it, potentially improving outcomes conditions such as osteomyelitis tumor removal while enabling collection of the material for...
Medial patellofemoral ligament (MPFL) reconstruction is a common procedure used to treat both acute and chronic patellar instability. Although many variations of MPFL have been described, there no consensus regarding the optimal surgical technique. We describe technique for with looped gracilis tendon autograft using suture anchors secure graft patella suspensory loop button system fixation femur. This replicates native shape while minimizing risk fracture allowing gradual tensioning graft.
Case: A 15-year-old boy with chondroblastoma of the right hemipelvis presented significant periacetabular bone destruction. Neoadjuvant denosumab treatment facilitated initial joint preserving surgery. Unfortunately, he experienced 2 local recurrences and underwent wide surgical resection years after his diagnosis. Conclusion: Inhibition receptor activator NF-κB (RANK)/RANK ligand (RANK-L) pathway has been used neoadjuvantly for giant cell tumor bone, but its role in is less understood. This...
Current standard of care for most intermediate and high-grade soft-tissue sarcomas (STS) includes limb-preserving surgical resection with either neoadjuvant radiation therapy (NRT) or adjuvant therapy. To date, there have been a few studies that attempt to correlate histopathologic response NRT oncologic outcomes in patients STS.Using our institutional database, we identified 58 who received followed by primary STS 34 without but did receive not any We analyzed four histologic parameters...
Unlike other soft tissue sarcomas, atypical lipomatous tumors (ALTs) are thought to have a low propensity for metastasis. Despite this, standard of care pulmonary metastasis (PM) surveillance has not been established. This study aimed evaluate the utility chest imaging PM following ALT excision.This was multi-institution, retrospective review all patients with primary ALTs extremities or superficial torso who underwent excision between 2006 and 2018. Minimum follow-up two years. Long-term...
Abstract Background There is discrepancy in the histologic concordance of pre-operative biopsy and post-surgical resection grading periacetabular chondrosarcoma. This poses a question as to whether treatment may differ depending on initial assessment tumor grade. Methods retrospective review patients with cartilaginous tumors who were treated between years 2000 2022 at single institution. All included analysis underwent surgical resection. The histological grades compared. Concordance...
<title>Abstract</title> Background In the United States, socioeconomic status (SES), race, and ethnicity are factors used to predict adverse outcomes in various carcinomas as well soft tissue sarcoma. However, existing evidence is unclear if race an independent predictor of overall survival common primary malignant bone tumors, including Ewing sarcoma, osteosarcoma, chondrosarcoma. Methods This a retrospective analysis National Cancer Database (NCDB) patients diagnosed with chondrosarcoma...
Abstract BACKGROUND: Psoralen is a natural ultraviolet activated compound that has been used for over 70 years to treat skin cancer, psoriasis, and vitiligo. Recently, expand its use beyond external treatment, novel therapeutic called X-PACT (X-ray psoralen cancer therapy) was created internal tumors. A combination of 8-methoxypsoralen phosphors convert low doses x-ray radiation (UV) light are injected into solid tumors subsequently by photons with considerable antineoplastic effect....
Abstract Benign, locally aggressive tumors of the distal femur are typically treated with intralesional curettage and polymethylmethacrylate (PMMA) cementation. However, it is not known whether plate fixation should be added to biomechanically augment these PMMA‐filled defects. The purpose this study was evaluate performance two competing techniques for reconstruction a femoral defect. For biomechanical study, we used 12 composite femurs properties comparable bone. In nine femurs, identical...