A5076959994- Clostridium difficile and Clostridium perfringens research
- Architecture and Art History Studies
- Antibiotic Use and Resistance
- Urinary Tract Infections Management
- Historical Art and Architecture Studies
- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- COVID-19 Clinical Research Studies
- Nosocomial Infections in ICU
- Microscopic Colitis
- Advanced Breast Cancer Therapies
- SARS-CoV-2 and COVID-19 Research
- Drug-Induced Adverse Reactions
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Infective Endocarditis Diagnosis and Management
- Infection Control in Healthcare
- Long-Term Effects of COVID-19
- COVID-19 and healthcare impacts
- Pelvic floor disorders treatments
- COVID-19 epidemiological studies
- Antibiotics Pharmacokinetics and Efficacy
- Renaissance and Early Modern Studies
- Pediatric Urology and Nephrology Studies
- Contact Dermatitis and Allergies
Duke University
2018-2025
Duke Medical Center
2016-2025
Institute of Cancer Research
2022-2025
Royal Marsden Hospital
2025
Open Invention Network (United States)
2024
Duke University Hospital
2019-2024
Oregon Medical Research Center
2022-2024
University of Pittsburgh
2024
Communities In Schools of Orange County
2022-2024
New York Proton Center
2022-2024
Importance Fewer than 5% of patients labeled with a penicillin allergy are truly allergic. The standard care to remove the label in adults is specialized testing involving prick and intradermal skin followed by an oral challenge penicillin. Skin resource intensive, limits practice specialist-trained physicians, restricts global population who could undergo delabeling. Objective To determine whether direct noninferior low-risk allergy. Design, Setting, Participants This parallel, 2-arm,...
Ceftobiprole is a cephalosporin that may be effective for treating complicated Staphylococcus aureus bacteremia, including methicillin-resistant S. aureus. Download PDF of the Research Summary. In this phase 3, double-blind, double-dummy, noninferiority trial, adults with bacteremia were randomly assigned in 1:1 ratio to receive ceftobiprole at dose 500 mg intravenously every 6 hours 8 days and thereafter, or daptomycin 10 per kilogram body weight 24 plus optional aztreonam (at discretion...
Highlights•Classical intrinsic subtypes change during neoadjuvant therapy from LumB to LumA•A reverse-transition back is observed in metastatic disease•Improved dimension reduction by comparison of pre- and post-therapeutic samples•Identification adaptive prognostic subsets high-risk luminal breast cancerSummaryWe evaluate therapy-induced molecular heterogeneity longitudinal samples high-risk, hormone-receptor positive/HER2-negative cancer patients with residual tumor after chemotherapy the...
Treatment options for drug-resistant cytomegalovirus (CMV) are limited. Letermovir is a novel antiviral recently approved CMV prophylaxis following hematopoietic cell transplantation, but its efficacy in other settings unknown.
Importance Black patients are more likely than White to be restrained during behavioral crises in emergency departments (EDs). Although the perils of policing mental health for individuals recognized, it is unclear whether or what extent police transport mediates association between race and use physical restraint EDs. Objective To evaluate degree which Design, Setting, Participants This retrospective, cross-sectional study used electronic record data from ED visits by adults (aged ≥18...
Abstract Background Substantial COVID-19 research investment has been allocated to randomized clinical trials (RCTs) on hydroxychloroquine/chloroquine, which currently face recruitment challenges or early discontinuation. We aimed estimate the effects of hydroxychloroquine and chloroquine survival in from all available RCT evidence, published unpublished. Methods: Rapid meta-analysis ongoing, completed, discontinued RCTs treatment for any patients (protocol: https://osf.io/QESV4/ )....
Child with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection typically have mild symptoms that do not require medical attention, leaving a gap in our understanding of the spectrum SARS-CoV-2-related illnesses viruses causes children.We conducted prospective cohort study children and adolescents (aged <21 years) SARS-CoV-2-infected close contact. We collected nasopharyngeal or nasal swabs at enrollment tested for SARS-CoV-2 using real-time polymerase chain reaction...
Few studies have examined the disproportionate use of restraints for Black adults receiving emergency psychiatric care. This study sought to determine whether odds physical and chemical restraint were higher patients undergoing care compared with their White counterparts.This single-center retrospective cohort 12,977 unique encounters an evaluation between January 1, 2014, September 18, 2020, at a large academic medical center in Durham, North Carolina. Self-reported race categories...
As SARS-CoV-2 continues to spread globally, questions have emerged regarding the strength and durability of immune responses in specific populations. In this study, we evaluated humoral 69 children adolescents with asymptomatic or mild symptomatic infection. We detected robust IgM, IgG, IgA antibody a broad array antigens at time acute infection 2 4 months after all participants. Notably, these were associated virus-neutralizing activity that was still detectable 94% children. Moreover,...
Children are less susceptible to SARS-CoV-2 infection and typically have milder illness courses than adults, but the factors underlying these age-associated differences not well understood. The upper respiratory microbiome undergoes substantial shifts during childhood is increasingly recognized influence host defense against pathogens. Thus, we sought identify features associated with susceptibility severity.We collected clinical data nasopharyngeal swabs from 285 children, adolescents,...
Staphylococcus aureus bacteremia is a life-threatening infection and leading cause of infective endocarditis, with mortality rates 15-50%. Treatment typically requires prolonged administration parenteral therapy, itself associated high costs potential catheter-associated complications. Dalbavancin lipoglycopeptide potent activity against long half-life, making it an appealing therapy for S. without the need durable central venous access.DOTS phase 2b, multicenter, randomized,...
Abstract Background: Clinicians and laboratories routinely use urinalysis (UA) parameters to determine whether antimicrobial treatment and/or urine cultures are needed. Yet the performance of individual UA common thresholds for action not well defined may vary across different patient populations. Methods: In this retrospective cohort study, we included all encounters with UAs ordered 24 hours prior a culture between 2015 2020 at 3 North Carolina hospitals. We evaluated relevant as potential...
Open AccessJournal of UrologyAdult Urology8 Feb 2024Proposing the "Continuum Urinary Tract Infection (UTI)" for a Nuanced Approach to Diagnosis and Management UTIs Sonali D. Advani, Nicholas A. Turner, Rebecca North, Rebekah W. Moehring, Valerie M. Vaughn, Charles Scales, Nazema Y. Siddiqui, Kenneth E. Schmader, Deverick J. Anderson AdvaniSonali Advani aCorresponding Author: Associate Professor Medicine-Infectious Diseases, Duke University School Medicine, 315 Trent Drive, Hanes House, Room...
Abstract In a multihospital cohort study of 3392 patients, positive urinalysis parameters had poor predictive value for diagnosing urinary tract infection (UTI). Combined (pyuria or nitrite) performed better than pyuria alone ruling out UTI. However, performance all was in older women.
ABSTRACT BACKGROUND Children with SARS-CoV-2 infection typically have mild symptoms that do not require medical attention, leaving a gap in our understanding of the spectrum illnesses virus causes children. METHODS We conducted prospective cohort study children and adolescents (<21 years age) SARS-CoV-2-infected close contact. collected nasopharyngeal or nasal swabs at enrollment tested for using real-time PCR assay. RESULTS Of 382 children, 289 (76%) were SARS-CoV-2-infected. more likely...
Abstract Background The increasing global prevalence of pulmonary nontuberculous mycobacteria (NTM) disease has called attention to challenges in NTM diagnosis and management. This study was conducted understand management outcomes patients with at diverse centers across the United States. Methods We a 10-year (2005–2015) retrospective 7 Vaccine Treatment Evaluation Units evaluate treatment human immunodeficiency virus–negative adults. Demographic clinical information abstracted through...
Penicillin allergies are frequently mislabeled, which may contribute to use of less-preferred alternative antibiotics.To evaluate a pharmacist-led allergy assessment program's association with antimicrobial and clinical outcomes.A program was launched in 2 phases (June 1, 2015, November 2, 2016) at single-center tertiary referral hospital. The longitudinal cross-sectional study included all period adult admissions; hospitalwide outcomes were assessed by segmented regression. Individual...
Importance Despite modest reductions in the incidence of hospital-onset Clostridioides difficile infection (HO-CDI), CDI remains a leading cause health care–associated infection. As no single intervention has proven highly effective on its own, multifaceted approach to controlling HO-CDI is needed. Objective To assess effectiveness Centers for Disease Control and Prevention’s Strategies Prevent Infection Acute Care Facilities Framework (hereafter, Framework) reducing incidence. Design,...
The natural history of C. difficile progression in nucleic acid amplification test (NAAT) positive, toxin enzyme immunoassay-negative patients remains poorly described. Better understanding risk for subsequent disease may improve prevention strategies. Describe the NAAT+/toxin- adults. A cohort adults (≥18 years) tested within Duke University Health System between 15 March 2020 and 31 December 2023 were classified as NAAT-, NAAT+/toxin-, or NAAT+/toxin+ followed up to 90 days. Three...