A5025546061- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Connexins and lens biology
- Retinal Development and Disorders
- Retinal Diseases and Treatments
- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Obesity, Physical Activity, Diet
- COVID-19 epidemiological studies
- Photoreceptor and optogenetics research
- RNA regulation and disease
- Folate and B Vitamins Research
- Genetics and Neurodevelopmental Disorders
- Ocular Disorders and Treatments
- Dietary Effects on Health
- Birth, Development, and Health
- Vaccine Coverage and Hesitancy
- Metabolism and Genetic Disorders
- Forensic and Genetic Research
- Intraocular Surgery and Lenses
- Neuropeptides and Animal Physiology
- Drug-Induced Ocular Toxicity
- Vitamin D Research Studies
- Long-Term Effects of COVID-19
- Hematological disorders and diagnostics
Chancellor University
2024
University of Health Sciences Lahore
2015-2024
Allama Iqbal Medical College
2011-2024
Shaheed Zulfiqar Ali Bhutto Institute of Science and Technology
2015-2024
Royal College of Surgeons in Ireland - Bahrain
2024
Rasool Akram Hospital
2011-2023
Rashid Latif Medical College
2023
Punjab Institute of Cardiology
2023
University of the Punjab
2023
Dow University of Health Sciences
2023
The ZF2001 vaccine, which contains a dimeric form of the receptor-binding domain severe acute respiratory syndrome coronavirus 2 and aluminum hydroxide as an adjuvant, was shown to be safe, with acceptable side-effect profile, immunogenic in adults phase 1 clinical trials.
There is no data on diet- and activity-related behaviors associated with overweight obesity among Pakistani school-aged children. The study aimed to explore dietary behaviors, physical activity sedentary lifestyle obesity, their socio-demographic correlates, primary school A population-based cross-sectional was conducted a representative multistage random cluster sample of 1860 children aged five twelve years in Lahore, Pakistan. Overweight (> +1 SD) +2 were defined using the World Health...
Abstract Intellectual disability (ID) is a clinically and genetically heterogeneous disorder, affecting 1–3% of the general population. Although research into genetic causes ID has recently gained momentum, identification pathogenic mutations that cause autosomal recessive (ARID) lagged behind, predominantly due to non-availability sizeable families. Here we present results exome sequencing in 121 large consanguineous Pakistani In 60 families, identified homozygous or compound heterozygous...
Abstract Background Knowledge about coronary heart disease (CHD) and its risk factors is an important pre-requisite for individual to implement behavioral changes leading towards CHD prevention. There scant data on the status of knowledge in general population Pakistan. The objective this study was assess a broad Pakistani identify associated with knowledge. Methods Cross sectional carried out at four tertiary care hospitals Pakistan using convenience sampling. Standard questionnaire used...
The objective of this study was to investigate the clinical characteristics patients with dengue viral infection during 2008 outbreak in Lahore order better understand pattern and severity disease Lahore.We analyzed 110 infected virus; data were collected on standardized collection sheets at two tertiary care hospitals from September December 2008. Dengue confirmed serologically or by real-time polymerase chain reaction (RT-PCR).Out total patients, 70 male 40 female. most common symptoms...
The aim of this study was to explore inequities in knowledge, attitudes and practices regarding tuberculosis (TB) among the urban rural populations.A cross-sectional conducted two districts Pakistan's Punjab province. 1080 subjects aged 20 years above, including 432 648 respondents, were randomly selected using multistage cluster sampling interviewed after taking verbal informed consent. Logistic regression used calculate crude odds ratio (OR) with 95% confidence interval (CI) for area....
Central obesity has been associated with the risk of cardiovascular and metabolic disease in children anthropometric indices predictive central include waist circumference (WC), waist-hip ratio (WHR) waist-height (WHtR). South Asian have higher body fat distribution trunk region but literature regarding WC related is scarce this region. The study was aimed to provide age- gender-specific WC, WHR WHtR smoothed percentiles, explore prevalence correlates obesity, among Pakistani aged five...
Child growth is internationally recognized as an important indicator of nutritional status and health in populations. This study was aimed to compare age- gender-specific height, weight BMI percentiles relative the international references among Pakistani school-aged children. A population-based conducted with a multistage cluster sample 1860 children aged five twelve years Lahore, Pakistan. Smoothed percentile curves were obtained comparison made World Health Organization 2007 (WHO) United...
Childhood obesity is becoming an equally challenging, yet under-recognized, problem in developing countries including Pakistan. Children and adolescents are worst affected with estimated 10% of the world's school-going children being overweight one quarter these obese. The study aimed to assess prevalence socioeconomic correlates obesity, trend statistics, among Pakistani primary school children. A population-based cross-sectional was conducted a representative multistage cluster sample 1860...
Abstract Background Substantial COVID-19 research investment has been allocated to randomized clinical trials (RCTs) on hydroxychloroquine/chloroquine, which currently face recruitment challenges or early discontinuation. We aimed estimate the effects of hydroxychloroquine and chloroquine survival in from all available RCT evidence, published unpublished. Methods: Rapid meta-analysis ongoing, completed, discontinued RCTs treatment for any patients (protocol: https://osf.io/QESV4/ )....
Scientific data regarding effects of platelet transfusion on count in dengue-related thrombocytopenia is scanty.A single center, randomized non-blinded trial was conducted adult patients with dengue fever and counts less than 30,000/μl. Patients were to treatment control group. Treatment group received donor platelets. post-transfusion increment (PPI) ≥10,000/μl and/or corrected (CCI) ≥5,000/μl 1 h considered responders. Primary outcome increments at 24 72 h.87 enrolled, 43 (48.2%)...
Purpose: To identify the genetic origins of autosomal recessive congenital cataracts (arCC) in Pakistani population. Methods: Based on hypothesis that most arCC patients consanguineous families Punjab areas Pakistan should be homozygous for causative mutations, affected individuals were screened homozygosity nearby highly informative microsatellite markers and then pathogenic mutations by DNA sequencing. A total 83 unmapped 33 known candidate genes. Results: Patients 32 near at least 1 CC...
Purpose: The Pakistan Punjab population has been a rich source for identifying genes causing or contributing to autosomal recessive retinal degenerations (arRD). This study was carried out delineate the genetic architecture of arRD in Pakistani population. Methods: origin total 144 families selected only having consanguineous marriages and multiple members affected with examined. Of these, causative mutations had identified 62 while locus an additional 15. remaining 67 were subjected...
We identified a homozygous missense alteration (c.75C>A, p.D25E) in CLCC1, encoding presumptive intracellular chloride channel highly expressed the retina, associated with autosomal recessive retinitis pigmentosa (arRP) eight consanguineous families of Pakistani descent. The p.D25E decreased CLCC1 function accompanied by accumulation mutant protein granules within ER lumen, while siRNA knockdown mRNA induced apoptosis cultured ARPE-19 cells. TALEN KO zebrafish was lethal 11 days post...
To explore the real-world safety and effectiveness of gliclazide modified release (MR) in patients with type 2 diabetes mellitus (T2DM) fasting during Ramadan.DIA-RAMADAN (NCT04132934) was a prospective, international, observational study conducted nine countries. Patients >18 years age T2DM (N = 1244) were examined at an inclusion visit (V0) occurring 6-8 weeks before start Ramadan. received diary to report treatment changes, hypoglycaemic events (HEs), other adverse events. Gliclazide MR...